{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:19:39Z","timestamp":1789586379295,"version":"build-2803163510"},"posted":{"date-parts":[[2026,7,9]]},"group-title":"Immunology","reference-count":107,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Psoriasis is a chronic autoimmune skin disorder marked by IL-17 producing gamma delta T cell (\u03b3\u03b4T17) and pruritus, but immunoregulatory roles of itch-inducing neurons in this context remain unclear. This study addressed whether non-peptidergic (NP) afferents bearing the Mas-related G protein-coupled receptor D (MrgprD\/NP1) and MrgprA3\/NP2 subsets had differential effects on psoriasiform immunopathology. Data show human NP1 and NP2 neurons basally expressed an array of pattern recognition and cytokine receptor genes and psoriatic human skin had a profound dysregulation of neuropeptides and their receptors. In mice, imiquimod (IMQ) application reduced the density of MrgprD+ skin afferents, whereas NP1 neuron ablation exacerbated IMQ-induced disease. Strikingly, NP1 activation using either optogenetics or \u03b2-alanine before IMQ exposure significantly reduced epidermal thickness, psoriatic clinical score and \u03b3\u03b4T17 cell accumulation. In stark contrast, NP2 activation increased the numbers of \u03b3\u03b4T17 cells that co-expressed amphiregulin (Areg) and exacerbated IMQ-driven skin pathology. Instead, pre-emptive NP1 stimulation shifted \u03b3\u03b4 T cell profiles away from being IL-17 and Areg dominant to IL-13+ \u03b3\u03b4 T cells expressing the transcription factor GATA3 accompanied by IL-10 secretion. Importantly, IL-10 signaling blockade reversed NP1-mediated suppression of IMQ-induced dermatitis. These data show that inflammatory skin disease can be distinctly modulated by sensory neuron subsets.<\/jats:p>","DOI":"10.64898\/2026.07.03.736363","type":"posted-content","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:45:43Z","timestamp":1783619143000},"source":"Crossref","is-referenced-by-count":1,"title":["Sensory neurons shape \u03b3\u03b4 T cell effector programs to control Psoriasiform Inflammation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-9139","authenticated-orcid":false,"given":"Juan M.","family":"Inclan-Rico","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"},{"name":"Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila M.","family":"Napuri","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8715-152X","authenticated-orcid":false,"given":"Ulrich M.","family":"Femoe","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fungai","family":"Musaigwa","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yin","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huasheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2486-807X","authenticated-orcid":false,"given":"Wenqin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-5365","authenticated-orcid":false,"given":"De\u2019Broski R.","family":"Herbert","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.1","doi-asserted-by":"crossref","first-page":"11724","DOI":"10.1038\/ncomms11724","article-title":"NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells","volume":"7","year":"2016","journal-title":"Nature Communications"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-025-00630-5","article-title":"Psoriasis","volume":"11","year":"2025","journal-title":"Nature Reviews Disease Primers"},{"issue":"8","key":"2026071109050791000_2026.07.03.736363v1.3","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/jamadermatol.2021.2007","article-title":"Psoriasis Prevalence in Adults in the United States","volume":"157","year":"2021","journal-title":"JAMA Dermatology"},{"key":"2026071109050791000_2026.07.03.736363v1.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"2026071109050791000_2026.07.03.736363v1.5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.2.187"},{"issue":"4","key":"2026071109050791000_2026.07.03.736363v1.6","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jid.2021.08.433","article-title":"TRPC3 Antagonizes Pruritus in a Mouse Contact Dermatitis Model","volume":"142","year":"2022","journal-title":"Journal of Investigative Dermatology"},{"key":"2026071109050791000_2026.07.03.736363v1.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3795-08.2008"},{"key":"2026071109050791000_2026.07.03.736363v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.15"},{"key":"2026071109050791000_2026.07.03.736363v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.001"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.10","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1038\/ncomms4986","article-title":"Differential developmental requirement and peripheral regulation for dermal V\u03b34 and V\u03b36T17 cells in health and inflammation","volume":"5","year":"2014","journal-title":"Nature Communications"},{"issue":"5","key":"2026071109050791000_2026.07.03.736363v1.11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00018-022-04299-x","article-title":"Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes","volume":"79","year":"2022","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.12","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.1038\/s41467-025-64106-6","article-title":"Single cell transcriptomics of human psoriasis and epidermal specific Ube2l3 deficient mice highlight CXCL16\/CXCR6 involvement in psoriasis development","volume":"16","year":"2025","journal-title":"Nature Communications"},{"key":"2026071109050791000_2026.07.03.736363v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.022"},{"key":"2026071109050791000_2026.07.03.736363v1.14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4476-07.2008"},{"key":"2026071109050791000_2026.07.03.736363v1.15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119766"},{"key":"2026071109050791000_2026.07.03.736363v1.16","doi-asserted-by":"crossref","unstructured":"Coto-Segura P , V\u00e1zquez-Coto D , Vel\u00e1zquez-Cuervo L , Garc\u00eda-Lago C , Coto E , Queiro R. The IFIH1\/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early- vs. Late-Onset Skin Disease and Increases the Risk of Arthritis in a Spanish Cohort of Psoriasis. International journal of molecular sciences 2023. p. 14803.","DOI":"10.20944\/preprints202306.0016.v1"},{"issue":"24","key":"2026071109050791000_2026.07.03.736363v1.17","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1016\/j.cub.2025.10.080","article-title":"Asymmetric lateral habenula function and peripheral neural mechanisms in regulating itch-evoked scratching","volume":"35","year":"2025","journal-title":"Current Biology"},{"key":"2026071109050791000_2026.07.03.736363v1.18","doi-asserted-by":"crossref","unstructured":"Cranfill SY, Huasheng ; Wang, Yingqi ; Inclan-Rico, Juan M. ; Janke, Emma ; Lezgiyeva, Karina ; Liu, Shibo ; Chang, Annabel ; Gooden, Steven ; Baker, Jane ; Shirvan, Sepenta ; Wu, Qinxue ; Bhattarai, Janardhan P. ; Hill, Rose Z. ; Ma, Minghong and Luo, Wenqin . Asymmetric Lateral Habenula Function and Peripheral Neural Mechanisms in Regulating Itch-Evoked Scratching. Current Biology 2025.","DOI":"10.2139\/ssrn.5279348"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.19","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1038\/ncomms12080","article-title":"IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin","volume":"7","year":"2016","journal-title":"Nature Communications"},{"key":"2026071109050791000_2026.07.03.736363v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.196."},{"key":"2026071109050791000_2026.07.03.736363v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.10.019"},{"issue":"3","key":"2026071109050791000_2026.07.03.736363v1.22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/mus.28196","article-title":"Risk of peripheral neuropathy in patients with psoriasis and psoriatic arthritis. A prospective cohort study","volume":"70","year":"2024","journal-title":"Muscle & Nerve"},{"issue":"11","key":"2026071109050791000_2026.07.03.736363v1.23","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/j.1468-3083.2009.03287.x","article-title":"Neuronal changes in psoriasis exacerbation","volume":"23","year":"2009","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"2026071109050791000_2026.07.03.736363v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.037"},{"key":"2026071109050791000_2026.07.03.736363v1.25","doi-asserted-by":"crossref","unstructured":"Fassett MS , Braz JM , Castellanos CA , Salvatierra JJ , Sadeghi M , Yu X , et al. IL-31\u2013dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis. Science Immunology;8(88):eabi6887.","DOI":"10.1126\/sciimmunol.abi6887"},{"key":"2026071109050791000_2026.07.03.736363v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07869-0"},{"key":"2026071109050791000_2026.07.03.736363v1.27","doi-asserted-by":"crossref","unstructured":"Furue M , Furue K , Tsuji G , Nakahara T . Interleukin-17A and Keratinocytes in Psoriasis. Int J Mol Sci 2020;21(4).","DOI":"10.3390\/ijms21041275"},{"key":"2026071109050791000_2026.07.03.736363v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2013.06.008"},{"key":"2026071109050791000_2026.07.03.736363v1.29","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2585"},{"issue":"5","key":"2026071109050791000_2026.07.03.736363v1.30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jid.2022.10.015","article-title":"IL-4\/IL-13 Inhibitors for Atopic Dermatitis Induce Psoriatic Rash Transcriptionally Close to Pustular Psoriasis","volume":"143","year":"2023","journal-title":"J Invest Dermatol"},{"issue":"11","key":"2026071109050791000_2026.07.03.736363v1.31","doi-asserted-by":"crossref","first-page":"113316","DOI":"10.1016\/j.celrep.2023.113316","article-title":"Pain and itch coding mechanisms of polymodal sensory neurons","volume":"42","year":"2023","journal-title":"Cell Reports"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","article-title":"Signaling pathways and targeted therapies for psoriasis","volume":"8","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"2026071109050791000_2026.07.03.736363v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3289"},{"key":"2026071109050791000_2026.07.03.736363v1.34","doi-asserted-by":"crossref","unstructured":"Han\u010d P , Gonzalez RJ , Mazo IB , Wang Y , Lambert T , Ortiz G , et al. Multimodal control of dendritic cell functions by nociceptors. Science;379(6639):eabm5658.","DOI":"10.1126\/science.abm5658"},{"key":"2026071109050791000_2026.07.03.736363v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2021.04.048"},{"issue":"3","key":"2026071109050791000_2026.07.03.736363v1.36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2340\/00015555-3086","article-title":"Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis","volume":"99","year":"2019","journal-title":"Acta Derm Venereol"},{"issue":"2","key":"2026071109050791000_2026.07.03.736363v1.37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdermsci.2018.08.007","article-title":"The vitamin D 3 analog, maxacalcitol, reduces psoriasiform skin inflammation by inducing regulatory T cells and downregulating IL-23 and IL-17 production","volume":"92","year":"2018","journal-title":"Journal of Dermatological Science"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41392-023-01653-8","article-title":"gammadelta T cells: origin and fate, subsets, diseases and immunotherapy","volume":"8","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026071109050791000_2026.07.03.736363v1.39","doi-asserted-by":"crossref","unstructured":"Ibusuki A , Kawai K , Nitahara-Takeuchi A , Arg\u00fcello RJ , Kanekura T . TCR signaling and cellular metabolism regulate the capacity of murine epidermal \u03b3\u03b4 T cells to rapidly produce IL-13 but not IFN-\u03b3. Frontiers in Immunology 2024;Volume 15 - 2024.","DOI":"10.3389\/fimmu.2024.1361139"},{"key":"2026071109050791000_2026.07.03.736363v1.40","doi-asserted-by":"crossref","unstructured":"Inclan-Rico JM , Napuri CM , Lin C , Hung L-Y , Ferguson AA , Liu X , et al. MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33. Nature Immunology 2024.","DOI":"10.1038\/s41590-024-01982-y"},{"key":"2026071109050791000_2026.07.03.736363v1.41","doi-asserted-by":"crossref","unstructured":"Inclan-Rico JM , Stephenson A , Napuri CM , Rossi HL , Hung L-Y , Pastore CF , et al. TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni. The Journal of Immunology 2025.","DOI":"10.1101\/2025.02.06.636930"},{"issue":"3","key":"2026071109050791000_2026.07.03.736363v1.42","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/jimmun\/vkae038","article-title":"Myeloid-derived IL-33 drives gammadelta T cell-dependent resistance against cutaneous infection by Strongyloides ratti","volume":"214","year":"2025","journal-title":"J Immunol"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.43","doi-asserted-by":"crossref","first-page":"14513","DOI":"10.1038\/s41598-018-32522-y","article-title":"Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway","volume":"8","year":"2018","journal-title":"Scientific Reports"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/exd.13403","article-title":"Imiquimod-applied Interleukin-10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state","volume":"27","year":"2018","journal-title":"Experimental Dermatology"},{"key":"2026071109050791000_2026.07.03.736363v1.45","doi-asserted-by":"crossref","unstructured":"Junsuwan N , Likittanasombat S , Chularojanamontri L , Chaiyabutr C , Wongpraparut C , Silpa-archa N . Prevalence and clinical characteristics of pruritus, and the factors significantly associated with high pruritic intensity in patients with psoriasis: a cross-sectional study. Annals of Medicine and Surgery 2023;85(7).","DOI":"10.1097\/MS9.0000000000000948"},{"key":"2026071109050791000_2026.07.03.736363v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.016"},{"key":"2026071109050791000_2026.07.03.736363v1.47","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12974"},{"key":"2026071109050791000_2026.07.03.736363v1.48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019755108"},{"issue":"6","key":"2026071109050791000_2026.07.03.736363v1.49","doi-asserted-by":"crossref","first-page":"727","DOI":"10.5021\/ad.2014.26.6.727","article-title":"Clinical Characteristics of Pruritus in Patients with Scalp Psoriasis and Their Relation with Intraepidermal Nerve Fiber Density","volume":"26","year":"2014","journal-title":"Ann Dermatol"},{"key":"2026071109050791000_2026.07.03.736363v1.50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802320115"},{"key":"2026071109050791000_2026.07.03.736363v1.51","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337620"},{"key":"2026071109050791000_2026.07.03.736363v1.52","doi-asserted-by":"publisher","DOI":"10.1038\/nature06116"},{"key":"2026071109050791000_2026.07.03.736363v1.53","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn9390"},{"key":"2026071109050791000_2026.07.03.736363v1.54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3509-12.2012"},{"key":"2026071109050791000_2026.07.03.736363v1.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.034"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.56","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1038\/s41467-023-39020-4","article-title":"Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis","volume":"14","year":"2023","journal-title":"Nature Communications"},{"key":"2026071109050791000_2026.07.03.736363v1.57","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"2026071109050791000_2026.07.03.736363v1.58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clim.2017.04.010","article-title":"IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFN\u03b3-producing T cells","volume":"184","year":"2017","journal-title":"Clinical Immunology"},{"key":"2026071109050791000_2026.07.03.736363v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.030"},{"key":"2026071109050791000_2026.07.03.736363v1.60","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01124-8"},{"key":"2026071109050791000_2026.07.03.736363v1.61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1936192100"},{"key":"2026071109050791000_2026.07.03.736363v1.62","doi-asserted-by":"crossref","unstructured":"Nakao M , Sugaya M , Fujita H , Miyagaki T , Morimura S , Shibata S , et al. TLR2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation through Decrease in Regulatory T Cells and Impaired IL-10 Production. International journal of molecular sciences 2020. p. 8560.","DOI":"10.3390\/ijms21228560"},{"issue":"3","key":"2026071109050791000_2026.07.03.736363v1.63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00403-012-1293-6","article-title":"Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients","volume":"305","year":"2013","journal-title":"Archives of Dermatological Research"},{"key":"2026071109050791000_2026.07.03.736363v1.64","doi-asserted-by":"crossref","first-page":"e29507","DOI":"10.7554\/eLife.29507","article-title":"Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors","volume":"6","year":"2017","journal-title":"eLife"},{"key":"2026071109050791000_2026.07.03.736363v1.65","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-16-06289.2000"},{"key":"2026071109050791000_2026.07.03.736363v1.66","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61862"},{"key":"2026071109050791000_2026.07.03.736363v1.67","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050340"},{"issue":"12","key":"2026071109050791000_2026.07.03.736363v1.68","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1007\/s00018-018-2788-x","article-title":"Regulatory functions of gammadelta T cells","volume":"75","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"2026071109050791000_2026.07.03.736363v1.69","doi-asserted-by":"publisher","DOI":"10.1080\/000155598441503"},{"key":"2026071109050791000_2026.07.03.736363v1.70","doi-asserted-by":"crossref","unstructured":"Que M , Wei Y , Wu S , Liang X , Zhang K , Wu G . Establishment of Psoriasis Mouse Model by Imiquimod. J Vis Exp 2025(220).","DOI":"10.3791\/68111"},{"key":"2026071109050791000_2026.07.03.736363v1.71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508990112"},{"key":"2026071109050791000_2026.07.03.736363v1.72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508990112"},{"key":"2026071109050791000_2026.07.03.736363v1.73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00544.x"},{"key":"2026071109050791000_2026.07.03.736363v1.74","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00444.x"},{"key":"2026071109050791000_2026.07.03.736363v1.75","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838354"},{"key":"2026071109050791000_2026.07.03.736363v1.76","doi-asserted-by":"publisher","DOI":"10.1038\/nature13199"},{"issue":"3","key":"2026071109050791000_2026.07.03.736363v1.77","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.4049\/jimmunol.1001001","article-title":"IL-23\u2013Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A","volume":"186","year":"2011","journal-title":"The Journal of Immunology"},{"key":"2026071109050791000_2026.07.03.736363v1.78","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-G\u00f3mez IM , Talker SC , K\u00e4ser T , Stadler M , Reiter L , Ladinig A , et al. Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine \u03b3\u03b4 T Cells. Frontiers in Immunology 2019;Volume 10 - 2019.","DOI":"10.3389\/fimmu.2019.00396"},{"key":"2026071109050791000_2026.07.03.736363v1.79","doi-asserted-by":"crossref","unstructured":"Sakai K , Sanders KM , Youssef MR , Yanushefski KM , Jensen L , Yosipovitch G , et al. Mouse model of imiquimod-induced psoriatic itch. PAIN 2016;157(11).","DOI":"10.1097\/j.pain.0000000000000674"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.80","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jid.2020.04.031","article-title":"Induction of Regulatory T Cells and Correction of Cytokine Disbalance by Short-Chain Fatty Acids: Implications for Psoriasis Therapy","volume":"141","year":"2021","journal-title":"Journal of Investigative Dermatology"},{"key":"2026071109050791000_2026.07.03.736363v1.81","doi-asserted-by":"publisher","DOI":"10.1261\/rna.064659.117"},{"key":"2026071109050791000_2026.07.03.736363v1.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.03.021"},{"key":"2026071109050791000_2026.07.03.736363v1.83","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1620-4"},{"issue":"13","key":"2026071109050791000_2026.07.03.736363v1.84","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1016\/j.celrep.2019.02.089","article-title":"Nppb Neurons Are Sensors of Mast Cell-Induced Itch","volume":"26","year":"2019","journal-title":"Cell Reports"},{"key":"2026071109050791000_2026.07.03.736363v1.85","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211250"},{"key":"2026071109050791000_2026.07.03.736363v1.86","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101824"},{"key":"2026071109050791000_2026.07.03.736363v1.87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10347.x"},{"key":"2026071109050791000_2026.07.03.736363v1.88","doi-asserted-by":"crossref","unstructured":"Taniguchi T , Md Mannoor K , Nonaka D , Toma H , Li C , Narita M , et al. A Unique Subset of \u03b3\u03b4 T Cells Expands and Produces IL-10 in Patients with Naturally Acquired Immunity against Falciparum Malaria. Frontiers in Microbiology 2017;Volume 8 - 2017.","DOI":"10.3389\/fmicb.2017.01288"},{"key":"2026071109050791000_2026.07.03.736363v1.89","doi-asserted-by":"crossref","unstructured":"Tseng P-Y , Hoon MA . Oncostatin M can sensitize sensory neurons in inflammatory pruritus. Science translational medicine;13(619):eabe3037.","DOI":"10.1126\/scitranslmed.abe3037"},{"issue":"1","key":"2026071109050791000_2026.07.03.736363v1.90","doi-asserted-by":"crossref","first-page":"8986","DOI":"10.1038\/s41598-018-27339-8","article-title":"Lymph node \u03b3\u03b4 and \u03b1\u03b2 CD8+ T cells share migratory properties","volume":"8","year":"2018","journal-title":"Scientific Reports"},{"key":"2026071109050791000_2026.07.03.736363v1.91","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3881"},{"key":"2026071109050791000_2026.07.03.736363v1.92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2123267119"},{"issue":"9","key":"2026071109050791000_2026.07.03.736363v1.93","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23\/IL-17 Axis1","volume":"182","year":"2009","journal-title":"The Journal of Immunology"},{"issue":"7","key":"2026071109050791000_2026.07.03.736363v1.94","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/cyto.a.22625","article-title":"FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data","volume":"87","year":"2015","journal-title":"Cytometry Part A"},{"key":"2026071109050791000_2026.07.03.736363v1.95","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0506331"},{"issue":"2","key":"2026071109050791000_2026.07.03.736363v1.96","doi-asserted-by":"crossref","first-page":"578","DOI":"10.4049\/jimmunol.1101972","article-title":"\u03b3\u03b4 T Cell Homing to Skin and Migration to Skin-Draining Lymph Nodes Is CCR7 Independent","volume":"188","year":"2012","journal-title":"The Journal of Immunology"},{"issue":"4","key":"2026071109050791000_2026.07.03.736363v1.97","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00403-024-02846-z","article-title":"Global burden and future trends in psoriasis epidemiology: insights from the global burden of disease study 2019 and predictions to 2030","volume":"316","year":"2024","journal-title":"Archives of Dermatological Research"},{"issue":"5","key":"2026071109050791000_2026.07.03.736363v1.98","doi-asserted-by":"crossref","first-page":"106764","DOI":"10.1016\/j.isci.2023.106764","article-title":"Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia","volume":"26","year":"2023","journal-title":"iScience"},{"key":"2026071109050791000_2026.07.03.736363v1.99","doi-asserted-by":"crossref","unstructured":"Xin Q , Zhang W , Yuan S . The Mechanism of the Channel Opening in Channelrhodopsin-2: A Molecular Dynamics Simulation. International Journal of Molecular Sciences 2023.","DOI":"10.3390\/ijms24065667"},{"issue":"10","key":"2026071109050791000_2026.07.03.736363v1.100","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.jid.2020.03.935","article-title":"Molecular Signature of Pruriceptive MrgprA3+ Neurons","volume":"140","year":"2020","journal-title":"Journal of Investigative Dermatology"},{"key":"2026071109050791000_2026.07.03.736363v1.101","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1112562"},{"key":"2026071109050791000_2026.07.03.736363v1.102","doi-asserted-by":"crossref","unstructured":"Yu H , Nagi SS , Usoskin D , Hu Y , Kupari J , Bouchatta O , et al. Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation. Nature Neuroscience 2024.","DOI":"10.1038\/s41593-024-01794-1"},{"key":"2026071109050791000_2026.07.03.736363v1.103","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.002"},{"issue":"11","key":"2026071109050791000_2026.07.03.736363v1.104","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/art.42942","article-title":"Genetically Proxied Interleukin-13 Inhibition Is Associated With Risk of Psoriatic Disease: A Mendelian Randomization Study","volume":"76","year":"2024","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"2026071109050791000_2026.07.03.736363v1.105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jdermsci.2018.11.009","article-title":"TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice","volume":"92","year":"2018","journal-title":"J Dermatol Sci"},{"issue":"12","key":"2026071109050791000_2026.07.03.736363v1.106","first-page":"5347","article-title":"Dermal V\u03b3(4)(+)T cells enhance the IMQ-induced psoriasis-like skin inflammatidon in re-challenged mice","volume":"9","year":"2017","journal-title":"Am J Transl Res"},{"key":"2026071109050791000_2026.07.03.736363v1.107","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.015"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.03.736363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:05:22Z","timestamp":1783785922000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.07.03.736363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":107,"URL":"https:\/\/doi.org\/10.64898\/2026.07.03.736363","relation":{},"subject":[],"published":{"date-parts":[[2026,7,9]]},"subtype":"preprint"}}