{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:30:46Z","timestamp":1785403846109,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,8]]},"group-title":"Cancer Biology","reference-count":67,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"DOI":"10.13039\/100000005","name":"United States Department of Defense","doi-asserted-by":"crossref","award":["W81XWH2010153"],"award-info":[{"award-number":["W81XWH2010153"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["NIH-R01CA264529"],"award-info":[{"award-number":["NIH-R01CA264529"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["NIH\/NCI R01CA284102"],"award-info":[{"award-number":["NIH\/NCI R01CA284102"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["NIH-R01CA276378"],"award-info":[{"award-number":["NIH-R01CA276378"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Cancer Society Mission Boost Grant"},{"name":"Duke Undergraduate Research Scholar award"},{"name":"The State of Texas Grant for Rare and Aggressive Breast Cancers"},{"DOI":"10.13039\/100009634","name":"Susan G. 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Using a previously defined 226 ASR-related genes, complementary preclinical models of tumor emboli and lymphatic circulating cell clusters, and independent patient cohorts, we identified ASR genes enriched for XIAP-NF\u03baB, oxidative stress response, inflammatory, and immune pathways.\n                  <jats:italic>CXCL8<\/jats:italic>\n                  emerged as one of the most highly upregulated transcripts in tumor emboli and was shared across both models; however,\n                  <jats:italic>CXCL8<\/jats:italic>\n                  ,\n                  <jats:italic>IL6<\/jats:italic>\n                  , and\n                  <jats:italic>PTGS2<\/jats:italic>\n                  were downregulated in lymphatic circulating cell clusters and LVI-positive triple-negative IBC patients, suggesting dynamic remodeling of inflammatory signaling during dissemination.\n                  <jats:italic>CYP4B1<\/jats:italic>\n                  was associated with ER status, LVI, and therapeutic response across multiple cohorts, implicating metabolic stress adaptation in dissemination.\n                  <jats:italic>IL6<\/jats:italic>\n                  and\n                  <jats:italic>PTGS2<\/jats:italic>\n                  were elevated in self-reported Black patients with triple-negative IBC compared to White patients. Pharmacologic inhibition of XIAP-NF\u03baB and oxidative stress pathways suppressed tumor emboli formation. Collectively, these findings identify ASR signaling as a framework linking tumor emboli survival, dissemination, and therapeutic vulnerability in IBC.\n                <\/jats:p>","DOI":"10.64898\/2026.07.06.734332","type":"posted-content","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:55:23Z","timestamp":1783504523000},"source":"Crossref","is-referenced-by-count":0,"title":["Tumor emboli-associated adaptive stress response signatures identify aggressive disease features in inflammatory breast cancer"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1719-4934","authenticated-orcid":false,"given":"Pritha","family":"Pai","sequence":"first","affiliation":[{"name":"Department of Surgery, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Biology, Duke Trinity College of Arts and Sciences, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-8961","authenticated-orcid":false,"given":"Ganiraju C.","family":"Manyam","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics & Computational Biology, MD Anderson Cancer Center, Houston, TX, USA"},{"name":"The University of Texas MD Anderson Cancer Center Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-0040","authenticated-orcid":false,"given":"Steven Van","family":"Laere","sequence":"additional","affiliation":[{"name":"Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, Antwerp, 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