{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:29:11Z","timestamp":1785421751375,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,9]]},"group-title":"Epidemiology","reference-count":36,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council","award":["MR\/W006774\/1"],"award-info":[{"award-number":["MR\/W006774\/1"]}]},{"award":["R01AG017644"],"award-info":[{"award-number":["R01AG017644"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Literature investigating mediation of the association between child abuse and dementia has largely considered composite adverse childhood experience scores rather than individual adverse experiences, despite evidence that different experiences have different impacts on dementia risk. Additionally, prior studies consider mediators in isolation, despite known associations between mediators which may impact indirect pathways from child abuse to dementia.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate whether potentially modifiable health and lifestyle factors mediate the association between child abuse and dementia.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used data from the English Longitudinal Study of Ageing to investigate associations between child abuse and dementia (N:5,448). Indirect pathways through four mediator categories (education, health behaviours, mental health and cardiovascular health) were examined. We used regression modelling to estimate associations between child abuse, mediators and dementia, and causal mediation analysis using the g-formula to estimate the joint indirect effect through the mediators.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Individuals who experienced child abuse had, on average, an 80% higher hazard of dementia, compared to those who did not (RTE HR:1.80, 95% CI:1.21-2.39). Mental health mediators showed strong associations with both child abuse and dementia. Evidence for other mediators was weaker. Education, health behaviours, mental health and cardiovascular health mediated approximately 18% of the association. Sensitivity analysis revealed that almost all this mediation occurred through mental health.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Child abuse was associated with higher risk of dementia. Joint mediation analysis suggested that education, health behaviours, cardiovascular health, and mental health accounted for a relatively small proportion of the observed association, with most mediation occurring through mental health. Future research must focus on other potential pathways from child abuse to dementia, including biological and social mechanisms.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>On average, child abuse was associated with an 80% higher hazard of dementia.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Modifiable health and lifestyle factors explained only 18% of the association.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Mental health accounted for most of the observed mediation.<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.07.26357433","type":"posted-content","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:55:29Z","timestamp":1783619729000},"source":"Crossref","is-referenced-by-count":0,"title":["Potentially modifiable mediators of the association between child abuse and dementia"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8389-1921","authenticated-orcid":false,"given":"Katherine","family":"Taylor","sequence":"first","affiliation":[{"name":"UCL Division of Psychiatry, University College London, 4th Floor Maple House, 149 Tottenham Court Road, London. 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SW17 0RE"},{"name":"Research Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 7HB"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1508-0598","authenticated-orcid":false,"given":"Emma","family":"Anderson","sequence":"additional","affiliation":[{"name":"UCL Division of Psychiatry, University College London, 4th Floor Maple House, 149 Tottenham Court Road, London. W1T 7NF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8635-9521","authenticated-orcid":false,"given":"Naaheed","family":"Mukadam","sequence":"additional","affiliation":[{"name":"UCL Division of Psychiatry, University College London, 4th Floor Maple House, 149 Tottenham Court Road, London. W1T 7NF"},{"name":"North London NHS Foundation Trust, St Pancras Hospital, 4 St Pancras Way, London. 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