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The placenta, a transient organ mediating maternal-fetal exchange, plays a central role in this process and has emerged as a key molecular archive\n                  <jats:italic>in utero<\/jats:italic>\n                  [2\u20134]. Placental DNA methylation (DNAm) is a unique mediator between prenatal exposures, fetal genetics and later-life outcomes [5\u20139]. DNAm quantitative trait loci (mQTL) have helped disentangling causal mechanisms underlying GWAS loci for complex diseases [10\u201315]. Despite growing evidence that placental genomic regulation has broad and profound effects on the developmental programming of early\u2013 and later-life health outcomes [17], existing placental studies remain limited in scale and largely focused on growth-and neuro-related traits [12\u201316]. Here, we construct a high-resolution placental mQTL resource and systematically investigate how placental DNAm relates to early\u2013 and later-life traits, and to shared vulnerability and complex interactions among them.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>Placental DNA methylation reveals molecular clues to how life before birth shapes health across the lifespan.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.07.26357471","type":"posted-content","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:50:14Z","timestamp":1783655414000},"source":"Crossref","is-referenced-by-count":0,"title":["Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-6840","authenticated-orcid":false,"given":"Ariadna","family":"Cilleros-Portet","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV\/EHU), Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-4931","authenticated-orcid":false,"given":"Itziar","family":"Gonz\u00e1lez-Moro","sequence":"additional","affiliation":[{"name":"Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV\/EHU), Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-0557","authenticated-orcid":false,"given":"Hachem","family":"Sadikki","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Mar\u00ed","sequence":"additional","affiliation":[{"name":"Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV\/EHU), Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-4550","authenticated-orcid":false,"given":"Todd M.","family":"Everson","sequence":"additional","affiliation":[{"name":"Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA"},{"name":"Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9948-5399","authenticated-orcid":false,"given":"Alba","family":"Hernang\u00f3mez-Laderas","sequence":"additional","affiliation":[{"name":"Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV\/EHU), Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-2124","authenticated-orcid":false,"given":"Lucile","family":"Bros\u00e9us","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l\u2019Avanc\u00e9e des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2683-0817","authenticated-orcid":false,"given":"Jorg","family":"Tost","sequence":"additional","affiliation":[{"name":"Laboratory for Epigenetics & Environment, Centre National de Recherche en G\u00e9nomique Humaine, CEA \u2013 Institut de Biologie Fran\u00e7ois Jacob, Universit\u00e9 Paris \u2013 Saclay, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5012-8983","authenticated-orcid":false,"given":"Marta","family":"Cos\u00edn-Tom\u00e0s","sequence":"additional","affiliation":[{"name":"ISGlobal, Barcelona, Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Barcelona InTerdisciplinary research group on plAnetary heaLth (BITAL), Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-7724","authenticated-orcid":false,"given":"Marika","family":"Groleau","sequence":"additional","affiliation":[{"name":"Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7381-904X","authenticated-orcid":false,"given":"Darina","family":"Czamara","sequence":"additional","affiliation":[{"name":"Department Genes and Environment, Max-Planck-Institute of Psychiatry, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-5959","authenticated-orcid":false,"given":"Manuel","family":"Lozano","sequence":"additional","affiliation":[{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de Val\u00e8ncia, Valencia, Spain"},{"name":"Epidemiology and Environmental Health Joint Research Unit, FISABIO\u2013Universitat Jaume I-University of Val\u00e8ncia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Tuhkanen","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-3908","authenticated-orcid":false,"given":"M. Daniele","family":"Fallin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-2747","authenticated-orcid":false,"given":"Rebecca J.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of California Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-915X","authenticated-orcid":false,"given":"Charles E.","family":"Breeze","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-294X","authenticated-orcid":false,"given":"Pierre-Etienne","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soile","family":"Hytti","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-3558","authenticated-orcid":false,"given":"Amaia","family":"Irizar","sequence":"additional","affiliation":[{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Department of Preventive Medicine and Public Health, Biogipuzkoa Health Research Institute and University of the Basque Country (UPV\/EHU), Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-5525","authenticated-orcid":false,"given":"Marius","family":"Lahti-Pulkkinen","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-6337","authenticated-orcid":false,"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-8660","authenticated-orcid":false,"given":"John","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-5297","authenticated-orcid":false,"given":"Jari","family":"Lahti","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine, University of Helsinki, Finland"},{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-1758","authenticated-orcid":false,"given":"Martine","family":"Vrijheid","sequence":"additional","affiliation":[{"name":"ISGlobal, Barcelona, Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Universitat Pompeu Fabra (UPF), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3124-3470","authenticated-orcid":false,"given":"Katri","family":"R\u00e4ikk\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-2585","authenticated-orcid":false,"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA"},{"name":"Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Department of Medicine, Faculty of Medicine and Health Sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, 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