{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:27:30Z","timestamp":1785432450153,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,14]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":29,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"funder":[{"award":["K23 AI40918"],"award-info":[{"award-number":["K23 AI40918"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32AI007044"],"award-info":[{"award-number":["T32AI007044"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AI027757"],"award-info":[{"award-number":["AI027757"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/01cp21a44","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Several novel tuberculosis vaccines (NTVs) are being evaluated in clinical trials. Understanding the perception of acceptability and confidence in NTVs will inform implementation strategies.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a cross-sectional survey to assess acceptability in and confidence of NTVs among adult persons with HIV (PWH) at two clinics in KwaZulu-Natal province, South Africa. We evaluated associations between acceptability and sociodemographic factors.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 225 PWH, 112 (50%) responded \u201cDefinitely yes, as soon as available\u201d, 86 (38%) \u201cDefinitely yes, but wait \u22656 months to receive it\u201d and 27 (12%) \u201cUnsure, leaning yes, any timeline\u201d to an NTV. Acceptability was associated with perception of tuberculosis\u2019s (TB\u2019s) importance in the community, perceived risk of contracting TB, personal history of TB, not currently living with someone with TB, incompatibility of vaccines with religion, and unemployment. Most participants were confident in the vaccine\u2019s potential safety (110, 93%) and effectiveness (221, 98%). Participants preferred to receive information from government, community, and health entities, or internet, and vaccination at community settings over public health facilities.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>NTV acceptability was high amongst these PWH, and they preferred community-based delivery models. Our findings may inform strategies to increase implementation of NTVs among PWH in South Africa.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.10.26357768","type":"posted-content","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:45:21Z","timestamp":1784047521000},"source":"Crossref","is-referenced-by-count":0,"title":["Acceptability of and confidence in novel tuberculosis vaccines among South African adults living with HIV"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9382-6570","authenticated-orcid":false,"given":"Alexa","family":"Giovanatti","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases. University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3453","authenticated-orcid":false,"given":"Nsika","family":"Sithole","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute, Somkhele Campus, Mtubatuba, KwaZulu-Natal, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-7388","authenticated-orcid":false,"given":"Indira","family":"Govender","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute, Somkhele Campus, Mtubatuba, KwaZulu-Natal, South Africa"},{"name":"London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8477-7583","authenticated-orcid":false,"given":"Heidi J.","family":"Larson","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine, London, United Kingdom"},{"name":"Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-0573","authenticated-orcid":false,"given":"Limakatso","family":"Lebina","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute, Somkhele Campus, Mtubatuba, KwaZulu-Natal, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9569-4097","authenticated-orcid":false,"given":"Paul K.","family":"Drain","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases. 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Scott","family":"McClelland","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases. University of Washington, Seattle, WA, USA"},{"name":"Department of Epidemiology, University of Washington, Seattle, WA, USA"},{"name":"Department of Global Health, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-939X","authenticated-orcid":false,"given":"Jennifer M.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases. 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