{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:18:44Z","timestamp":1785403124334,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,13]]},"group-title":"Cell Biology","reference-count":72,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["DK095045"],"award-info":[{"award-number":["DK095045"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["DK099465"],"award-info":[{"award-number":["DK099465"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32GM007753"],"award-info":[{"award-number":["T32GM007753"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32GM144273"],"award-info":[{"award-number":["T32GM144273"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32GM007226"],"award-info":[{"award-number":["T32GM007226"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["F30DK127546"],"award-info":[{"award-number":["F30DK127546"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/05ewr7t48","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Slim Initiative in Genomic Medicine for the Americas"},{"award":["U24-CA210986"],"award-info":[{"award-number":["U24-CA210986"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["U01 CA214125"],"award-info":[{"award-number":["U01 CA214125"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/019a0gk53","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/014pcm848","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>\n                  Severe proteinopathies\u2014such as retinitis pigmentosa, a form of inherited blindness\u2014are driven by genetic mutations that overwhelm the quality control of the post-endoplasmic reticulum (post-ER) secretory pathway, causing toxic protein accumulation. Here, we identify a therapeutic node defined by a hetero-oligomeric cargo receptor complex consisting of TMED7, 2, 9, and 10. This \u201centrapment complex\u201d anchors structurally and functionally diverse mutant clients within the early secretory pathway via TMED7 binding to the integral Golgi protein GRASP55. Disruption of the entrapment complex results in the clearance of accumulated protein cargoes.\n                  <jats:italic>In vivo<\/jats:italic>\n                  ablation of the entrapment node via inducible genetic deletion or via the small molecule BRD7635 reverses histopathological hallmarks and rescues functional deficits in clinically distinct proteinopathies of the kidney and the eye, including mitigating vision loss in a mouse model of retinitis pigmentosa.\n                <\/jats:p>","DOI":"10.64898\/2026.07.10.737576","type":"posted-content","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:05:32Z","timestamp":1783947932000},"source":"Crossref","is-referenced-by-count":0,"title":["A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies"],"prefix":"10.64898","author":[{"given":"Magdalena","family":"Riedl Khursigara","sequence":"first","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa C.","family":"Goss","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Harvard\/MIT MD-PhD Program, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kost-Alimova","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Keller","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Danielle","family":"De Mata","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjithmenon","family":"Muraleedharan","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Ryan","family":"Collantes","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brown","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Grinkevich","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felichi Mae","family":"Arines","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lin","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Byrne","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Bazua Valenti","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Morici","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Roignot","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Zavras","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna R.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Carlos","family":"Ignacio","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoochan","family":"Myung","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seulki","family":"Kwon","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Nelson","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyery","family":"Yoo","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Melanson","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Racette","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Padovano","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth L.","family":"Alper","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Carey","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata D.","family":"Udeshi","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Carr","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Dvela-Levitt","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Narimatsu","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Sakuno","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor San Martin Carvalho","family":"Correa","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos E.","family":"Efstathiou","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios P.","family":"Ntentakis","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Cao","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Dong","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Thien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolline","family":"Rodrigues Menezes","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA"},{"name":"Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Kurumbail","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kazmirski","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Liu","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaiya","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Lander","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios G.","family":"Vavvas","sequence":"additional","affiliation":[{"name":"Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Palczewski","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA"},{"name":"Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA"},{"name":"Department of Chemistry, University of California, Irvine, Irvine, CA, USA. Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Lorenzo B.","family":"Pablo","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Greka","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"},{"name":"Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026071605050679000_2026.07.10.737576v1.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"2026071605050679000_2026.07.10.737576v1.2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007526"},{"key":"2026071605050679000_2026.07.10.737576v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3588"},{"key":"2026071605050679000_2026.07.10.737576v1.4","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201610031"},{"key":"2026071605050679000_2026.07.10.737576v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0001-6"},{"key":"2026071605050679000_2026.07.10.737576v1.6","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201906047"},{"key":"2026071605050679000_2026.07.10.737576v1.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"2026071605050679000_2026.07.10.737576v1.8","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023523"},{"key":"2026071605050679000_2026.07.10.737576v1.9","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709072"},{"key":"2026071605050679000_2026.07.10.737576v1.10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-physiol-031522-100639","article-title":"Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond","volume":"85","year":"2023","journal-title":"Annu. Rev. Physiol"},{"key":"2026071605050679000_2026.07.10.737576v1.11","doi-asserted-by":"publisher","DOI":"10.3390\/genes11101120"},{"key":"2026071605050679000_2026.07.10.737576v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.212"},{"key":"2026071605050679000_2026.07.10.737576v1.13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46740"},{"key":"2026071605050679000_2026.07.10.737576v1.14","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005275"},{"key":"2026071605050679000_2026.07.10.737576v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.03.156"},{"key":"2026071605050679000_2026.07.10.737576v1.16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180347"},{"key":"2026071605050679000_2026.07.10.737576v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.002"},{"key":"2026071605050679000_2026.07.10.737576v1.18","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070234"},{"key":"2026071605050679000_2026.07.10.737576v1.19","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.062950"},{"key":"2026071605050679000_2026.07.10.737576v1.20","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201012074"},{"key":"2026071605050679000_2026.07.10.737576v1.21","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-04-0294"},{"key":"2026071605050679000_2026.07.10.737576v1.22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.568311"},{"key":"2026071605050679000_2026.07.10.737576v1.23","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvab108"},{"key":"2026071605050679000_2026.07.10.737576v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.026"},{"key":"2026071605050679000_2026.07.10.737576v1.25","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00709-015-0858-6","article-title":"p24 family proteins: key players in the regulation of trafficking along the secretory pathway","volume":"253","year":"2016","journal-title":"Protoplasma"},{"key":"2026071605050679000_2026.07.10.737576v1.26","doi-asserted-by":"crossref","first-page":"e3003084","DOI":"10.1371\/journal.pbio.3003084","article-title":"TMED9 coordinates the clearance of misfolded GPI-anchored proteins out of the ER and into the Golgi","volume":"23","year":"2025","journal-title":"PLoS Biol"},{"key":"2026071605050679000_2026.07.10.737576v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.165"},{"key":"2026071605050679000_2026.07.10.737576v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.04.151"},{"key":"2026071605050679000_2026.07.10.737576v1.29","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/tra.12912","article-title":"Anterograde trafficking of Toll-like receptors requires the cargo sorting adaptors TMED-2 and 7","volume":"24","year":"2023","journal-title":"Traffic"},{"key":"2026071605050679000_2026.07.10.737576v1.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07173.x"},{"key":"2026071605050679000_2026.07.10.737576v1.31","doi-asserted-by":"publisher","DOI":"10.1042\/BC20080233"},{"key":"2026071605050679000_2026.07.10.737576v1.32","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2012-0028"},{"key":"2026071605050679000_2026.07.10.737576v1.33","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672319000090"},{"key":"2026071605050679000_2026.07.10.737576v1.34","first-page":"1096899","article-title":"The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis","volume":"10","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026071605050679000_2026.07.10.737576v1.35","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.87272"},{"key":"2026071605050679000_2026.07.10.737576v1.36","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142743"},{"key":"2026071605050679000_2026.07.10.737576v1.37","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049336"},{"key":"2026071605050679000_2026.07.10.737576v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.10.002"},{"key":"2026071605050679000_2026.07.10.737576v1.39","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000527"},{"key":"2026071605050679000_2026.07.10.737576v1.40","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6266"},{"key":"2026071605050679000_2026.07.10.737576v1.41","doi-asserted-by":"publisher","DOI":"10.1002\/cpmo.39"},{"key":"2026071605050679000_2026.07.10.737576v1.42","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1153934"},{"key":"2026071605050679000_2026.07.10.737576v1.43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2416827121"},{"key":"2026071605050679000_2026.07.10.737576v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00246-X"},{"key":"2026071605050679000_2026.07.10.737576v1.45","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.6.1043"},{"key":"2026071605050679000_2026.07.10.737576v1.46","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.6.1923"},{"key":"2026071605050679000_2026.07.10.737576v1.47","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.6.1939"},{"key":"2026071605050679000_2026.07.10.737576v1.48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.518340"},{"key":"2026071605050679000_2026.07.10.737576v1.49","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.035055"},{"key":"2026071605050679000_2026.07.10.737576v1.50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.765990"},{"key":"2026071605050679000_2026.07.10.737576v1.51","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200108102"},{"key":"2026071605050679000_2026.07.10.737576v1.52","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-01-0069"},{"key":"2026071605050679000_2026.07.10.737576v1.53","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1080\/13543784.2020.1804853","article-title":"Antisense oligonucleotide therapeutics in clinical trials for the treatment of inherited retinal diseases","volume":"29","year":"2020","journal-title":"Expert Opin. Investig. Drugs"},{"key":"2026071605050679000_2026.07.10.737576v1.54","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/s41591-026-04230-y","article-title":"Clinically distinct genetic diseases converge on shared, druggable nodes","volume":"32","year":"2026","journal-title":"Nat. Med"},{"key":"2026071605050679000_2026.07.10.737576v1.55","doi-asserted-by":"crossref","first-page":"eadp2221","DOI":"10.1126\/sciadv.adp2221","article-title":"Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway","volume":"10","year":"2024","journal-title":"Sci. Adv"},{"key":"2026071605050679000_2026.07.10.737576v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.261"},{"key":"2026071605050679000_2026.07.10.737576v1.57","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"2026071605050679000_2026.07.10.737576v1.58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2219953120"},{"key":"2026071605050679000_2026.07.10.737576v1.59","doi-asserted-by":"publisher","DOI":"10.1021\/ac950914h"},{"key":"2026071605050679000_2026.07.10.737576v1.60","doi-asserted-by":"publisher","DOI":"10.1002\/jms.229"},{"key":"2026071605050679000_2026.07.10.737576v1.61","doi-asserted-by":"publisher","DOI":"10.1016\/1044-0305(94)80016-2"},{"key":"2026071605050679000_2026.07.10.737576v1.62","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq706"},{"key":"2026071605050679000_2026.07.10.737576v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-024-07487-W"},{"key":"2026071605050679000_2026.07.10.737576v1.64","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","year":"2015","journal-title":"SoftwareX"},{"key":"2026071605050679000_2026.07.10.737576v1.65","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"2026071605050679000_2026.07.10.737576v1.66","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067"},{"key":"2026071605050679000_2026.07.10.737576v1.67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00935"},{"key":"2026071605050679000_2026.07.10.737576v1.68","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"2026071605050679000_2026.07.10.737576v1.69","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"2026071605050679000_2026.07.10.737576v1.70","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.3.CO;2-L"},{"key":"2026071605050679000_2026.07.10.737576v1.71","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"2026071605050679000_2026.07.10.737576v1.72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00512"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.10.737576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:05:16Z","timestamp":1784203516000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.07.10.737576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":72,"URL":"https:\/\/doi.org\/10.64898\/2026.07.10.737576","relation":{},"subject":[],"published":{"date-parts":[[2026,7,13]]},"subtype":"preprint"}}