{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:02:52Z","timestamp":1784552572045,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,16]]},"group-title":"Occupational and Environmental Health","reference-count":72,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Copper (Cu) is an essential metal involved in neurobiological processes including energy metabolism and neurotransmission, yet dysregulated Cu levels may adversely affect brain health and olfactory performance. Although olfactory dysfunction has primarily been studied in older adults and neurodegenerative disease, adolescence is a critical period of brain maturation during which the olfactory system may be particularly vulnerable. This cross-sectional study examined associations between Cu exposure, olfactory bulb (OB) volume, and olfactory performance in 200 adolescents and young adults (64% female; ages 13\u201325) from the Public Health Impact of Metals Exposure cohort. Cu concentrations in blood, urine, hair, and saliva were measured using inductively coupled plasma mass spectrometry. T2-weighted magnetic resonance imaging scans estimated left, right, and total OB volumes using a three-stage deep learning pipeline. Olfactory performance was assessed using the Sniffin\u2019 Sticks test. Weighted quantile sum regression evaluated associations between a Cu mixture index and OB outcomes, while standard linear regression models assessed individual Cu biomarkers. Models were adjusted for age and sex. A higher Cu index was associated with reduced left (\u03b2 = \u22120.72, 95% CI [\u22121.42, \u22120.02]), right (\u03b2 = \u22120.79, 95% CI [\u22121.43, \u22120.15]), and total OB volume (\u03b2 = \u22121.55, 95% CI [\u22122.85, \u22120.25]), as well as lower odor threshold scores (\u03b2 = \u22120.23, 95% CI [\u22120.42, \u22120.03]). Individual biomarkers were not independently associated with outcomes. These findings suggest that Cu exposure may adversely affect olfactory neurodevelopment during adolescence and highlight the importance of studying environmental exposures relevant to long-term neurological health.<\/jats:p>","DOI":"10.64898\/2026.07.13.26357935","type":"posted-content","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:20:11Z","timestamp":1784240411000},"source":"Crossref","is-referenced-by-count":0,"title":["Multi-matrix copper exposure is associated with reduced olfactory bulb volume and odor sensitivity in adolescents"],"prefix":"10.64898","author":[{"given":"Michelle A.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 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