{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:07:07Z","timestamp":1784538427459,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,16]]},"group-title":"Epidemiology","reference-count":35,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["MH128955"],"award-info":[{"award-number":["MH128955"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Social relationships are an important social determinant of health. Loneliness, the perceived gap between one\u2019s actual and desired relationships, has emerged as an important mechanism through which social relationships impact health. Like other intrapersonal-level factors associated with health, loneliness is influenced by broader social and structural factors, including characteristics of one\u2019s neighborhood social environment. Although neighborhood-level protective and risk factors for loneliness and for mental health have been identified, prior studies have often focused solely on self-reported perceptions of the neighborhood environment. Further, few have considered aspects of the neighborhood social environments, such as neighborhood stability (i.e., stability of the community with long or short-term residents), independent of neighborhood socioeconomic conditions. In the current analysis, we explored longitudinal patterns of loneliness in conjunction with neighborhood stability among women with HIV (WWH) enrolled into the MACS\/WIHS Combined Cohort Study (MWCCS) from 2014\u20132019 (\n                  <jats:italic>N<\/jats:italic>\n                  <jats:sub>2019<\/jats:sub>\n                  =1,394) to examine whether trajectories of loneliness and neighborhood stability were associated with depressive symptoms, non-prescription substance use, past-year cannabis use, number of alcoholic drinks per week, and several domains of quality of life. Loneliness at baseline (Betas = 0.24 \u2013 0.54) and changes in loneliness over time (Betas = 0.11 \u2013 0.26) were associated with each outcome, except for the association between changes in loneliness over time and drinks per week (Beta=0.13,\n                  <jats:italic>p<\/jats:italic>\n                  = 4.14\u00d710\n                  <jats:sup>-2<\/jats:sup>\n                  ), which did not persist after correcting for multiple comparisons. Neighborhood stability at baseline was associated with past year cannabis use (Beta=0.26,\n                  <jats:italic>p<\/jats:italic>\n                  = 1.00\u00d710\n                  <jats:sup>-2<\/jats:sup>\n                  ), depressive symptoms (Beta=-0.12,\n                  <jats:italic>p<\/jats:italic>\n                  = 1.54\u00d710\n                  <jats:sup>-3<\/jats:sup>\n                  ), and overall self-reported health (Beta=-0.08,\n                  <jats:italic>p<\/jats:italic>\n                  = 2.05\u00d710\n                  <jats:sup>-2<\/jats:sup>\n                  ). Changes in neighborhood stability across time were not associated with any outcome. Neighborhood stability moderated the association between changes in loneliness and general health perceptions. Our results demonstrate both overall loneliness and changes in loneliness over time have implications for current mental health in WWH, while changes in neighborhood stability did not.\n                <\/jats:p>","DOI":"10.64898\/2026.07.14.26358061","type":"posted-content","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:10:19Z","timestamp":1784232619000},"source":"Crossref","is-referenced-by-count":0,"title":["Associations of Trajectories of Loneliness and Neighborhood Stability with Depression, Alcohol and Substance Use, and Quality of Life among Women Living with HIV"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-657X","authenticated-orcid":false,"given":"Peter","family":"Barr","sequence":"first","affiliation":[{"name":"VA New York Harbor Healthcare System, Brooklyn, NY"},{"name":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY"},{"name":"Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, Brooklyn, NY"},{"name":"Department of Community Health Sciences, State University of New York, Downstate Health Sciences University, Brooklyn, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Aouizerat","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, New York University, New York, NY"},{"name":"Translational Research Center, College of Dentistry, New York University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mardge","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stroger Hospital of Cook County Health and Hospitals System, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Cook","sequence":"additional","affiliation":[{"name":"Center on Mental Health Services Research and Policy, University of Illinois, Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Reuel","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Urban-Global Public Health, Rutgers School of Public Health, Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Haberlen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Holman","sequence":"additional","affiliation":[{"name":"Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam-Colette","family":"Kempf","sequence":"additional","affiliation":[{"name":"Schools of Nursing, Public Health and Medicine, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Konkle-Parker","sequence":"additional","affiliation":[{"name":"Schools of Nursing, Medicine and Population Health, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennafer L.","family":"Kwait","sequence":"additional","affiliation":[{"name":"Whitman-Walker Institute, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Plankey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Georgetown University, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah H.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"},{"name":"Departments of Neurology and Psychiatry and Behavioral Sciences, and Molecular and Cellular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Rubtsova","sequence":"additional","affiliation":[{"name":"Department of Behavioral, Social, and Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Northwell Health, New Hyde Park, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azure B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, State University of New York, Downstate Health Sciences University, Brooklyn, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-8555","authenticated-orcid":false,"given":"Jacquelyn L.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY"},{"name":"Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, Brooklyn, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, State University of New York, Downstate Health Sciences University, Brooklyn, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026072001400436000_2026.07.14.26358061v1.1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy021"},{"key":"2026072001400436000_2026.07.14.26358061v1.2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2023.01037"},{"key":"2026072001400436000_2026.07.14.26358061v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcr.2018.01.005"},{"key":"2026072001400436000_2026.07.14.26358061v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthplace.2018.02.007"},{"key":"2026072001400436000_2026.07.14.26358061v1.5","doi-asserted-by":"publisher","DOI":"10.2307\/2346101"},{"key":"2026072001400436000_2026.07.14.26358061v1.6","unstructured":"Cohen, M. , & Pettit, K. 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