{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:02:05Z","timestamp":1784721725520,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,20]]},"group-title":"Neuroscience","reference-count":89,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["P50DC019900"],"award-info":[{"award-number":["P50DC019900"]}]},{"name":"National Institute of Health","award":["R01NS100440"],"award-info":[{"award-number":["R01NS100440"]}]},{"name":"National Institute of Health","award":["R01DC017091"],"award-info":[{"award-number":["R01DC017091"]}]},{"name":"National Institute of Health","award":["R01DC017696"],"award-info":[{"award-number":["R01DC017696"]}]},{"name":"National Science Foundation","award":["2034836"],"award-info":[{"award-number":["2034836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>A central challenge in systems neuroscience is understanding how computational mechanisms\u2014including those implemented within a single brain region\u2014interact to produce behavior. For example, prior work in the literature attributes many computational functions to the cerebellum, but these functions have been tested in isolation and it remains unclear how they jointly contribute to motor control. Here, we test several established hypotheses of cerebellar function: internal modeling, timing of movement dynamics, sensory-error processing, delay processing, and multimodal integration. We first formalize these functions as mechanistic parameters within a computational model of speech motor control. We then use this formalism to investigate the relative contribution of each function to the abnormal speech corrective response seen in adults with cerebellar degeneration during perturbed auditory feedback. We find the following functions explain most of the behavioral differences: internal modeling, timing of movement dynamics, and multimodal integration. We also show that the key mechanisms have a trade-off relationship, and that cerebellar degeneration modulates those trade-off strengths and boundaries. These results both elaborate the mechanistic function of the cerebellum in speech feedback control and, more broadly, demonstrate the promise of using this paradigm to simultaneously test competing theories of neural function underlying behavior.<\/jats:p>","DOI":"10.64898\/2026.07.14.738521","type":"posted-content","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:40:15Z","timestamp":1784583615000},"source":"Crossref","is-referenced-by-count":0,"title":["Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-0777","authenticated-orcid":false,"given":"Alvinc\u00e9 L","family":"Pongos","sequence":"first","affiliation":[{"name":"Department of Bioengineering, UC Berkeley - UCSF, University of California-San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3600-7090","authenticated-orcid":false,"given":"Kwang S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2632-8851","authenticated-orcid":false,"given":"Jessica L.","family":"Gaines","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Ramanarayanan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, University of California-San Francisco, San Francisco, California, USA"},{"name":"Modality.ai, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nefeli","family":"Chanoutsi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California-San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2617-7301","authenticated-orcid":false,"given":"Rabab","family":"Rangwala","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3574-1343","authenticated-orcid":false,"given":"Kurtis","family":"Brent","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, UC Berkeley - UCSF, University of California-San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-2884","authenticated-orcid":false,"given":"Benjamin","family":"Parrell","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9714-8646","authenticated-orcid":false,"given":"John F.","family":"Houde","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, University of California-San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-3857","authenticated-orcid":false,"given":"Srikantan S.","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, University of California-San Francisco, San Francisco, California, USA"},{"name":"Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026072204100774000_2026.07.14.738521v1.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1280-5"},{"key":"2026072204100774000_2026.07.14.738521v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.062"},{"key":"2026072204100774000_2026.07.14.738521v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2015.12.003"},{"key":"2026072204100774000_2026.07.14.738521v1.4","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01602"},{"key":"2026072204100774000_2026.07.14.738521v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(98)01221-2"},{"key":"2026072204100774000_2026.07.14.738521v1.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1597-z"},{"key":"2026072204100774000_2026.07.14.738521v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-6080(96)00035-4"},{"key":"2026072204100774000_2026.07.14.738521v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)00028-8"},{"key":"2026072204100774000_2026.07.14.738521v1.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569931"},{"key":"2026072204100774000_2026.07.14.738521v1.10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.98841.3"},{"key":"2026072204100774000_2026.07.14.738521v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.04.006"},{"key":"2026072204100774000_2026.07.14.738521v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2332"},{"issue":"5","key":"2026072204100774000_2026.07.14.738521v1.13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s12311-022-01406-3","article-title":"Cerebellar representations of errors and internal models","volume":"21","year":"2022","journal-title":"The Cerebellum"},{"key":"2026072204100774000_2026.07.14.738521v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/0025-5564(71)90051-4"},{"key":"2026072204100774000_2026.07.14.738521v1.15","first-page":"162","article-title":"Neurophysiological aspects of the cerebellar motor control system","volume":"7","year":"1970","journal-title":"International journal of neurology"},{"key":"2026072204100774000_2026.07.14.738521v1.16","doi-asserted-by":"crossref","unstructured":"David Marr . \u201cA theory of cerebellar cortex\u201d. 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