{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:38:05Z","timestamp":1792870685977,"version":"4.5.0"},"posted":{"date-parts":[[2026,7,20]]},"group-title":"Neuroscience","reference-count":43,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NIAAA","award":["R01AA028770"],"award-info":[{"award-number":["R01AA028770"]}]},{"name":"NIH\/NIAAA","award":["T32DA0077234"],"award-info":[{"award-number":["T32DA0077234"]}]},{"name":"NIH\/NIAAA","award":["F32AA032737"],"award-info":[{"award-number":["F32AA032737"]}]},{"name":"MnDRIVE Postdoctoral Fellowship in Neuromodulation Research"},{"name":"NIDA","award":["P30 DA048742-01A1 University of Minnesota Center for Neural Circuits in Addiction Pilot Grant"],"award-info":[{"award-number":["P30 DA048742-01A1 University of Minnesota Center for Neural Circuits in Addiction Pilot Grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Alcohol use disorder is characterized by continued alcohol use despite negative consequences, also known as aversion-resistant drinking. Alcohol related cues can invigorate motivation to seek and consume alcohol. It is currently unknown whether alcohol related cues can invigorate drinking despite negative consequences.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Long-Evans rats were trained in a discriminative stimulus (DS) task with cues predicting the availability of an alcohol reward. They were then tested in the task for aversion-resistant drinking by measuring consumption of alcohol adulterated with increasing concentrations of quinine. As a control for an environment free of explicit reward-related cues, rats were also tested for aversion-resistant drinking in the home cage.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that rats displayed robust aversion-resistant drinking in the DS task. When we compared alcohol consumption in the task with home cage consumption, we found that rats were more aversion-resistant in the task than in the home cage. We also found that individual differences in aversion-resistant drinking were correlated within behavioral context (i.e. home cage or DS task) but not between the home cage and the DS task.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found that aversion-resistant drinking is invigorated during cue-induced alcohol seeking relative to free drinking without explicit alcohol cues. Home cage quinine-sensitivity is unrelated to quinine-sensitivity in the presence of cues. This suggests that cues motivate drinking despite negative consequences in a way that is unique from aversion-resistance driven by drinking history. While many behavioral measures use cues and ultimately test aversion-resistant drinking, this is the first explicit test of cue-evoked aversion-resistant drinking.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.14.738545","type":"posted-content","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:05:18Z","timestamp":1784592318000},"source":"Crossref","is-referenced-by-count":0,"title":["Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1690-7956","authenticated-orcid":false,"given":"Meredith R.","family":"Bauer","sequence":"first","affiliation":[{"name":"University of Minnesota, Department of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-0418","authenticated-orcid":false,"given":"Jocelyn M.","family":"Richard","sequence":"additional","affiliation":[{"name":"University of Minnesota, Department of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026102412300864000_2026.07.14.738545v2.1","unstructured":"American Psychiatric Association. 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