{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:01:38Z","timestamp":1784847698674,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,21]]},"group-title":"Neuroscience","reference-count":106,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Mild traumatic brain injury (mTBI) is the most common form of central nervous system (CNS) injury and is often characterized by persistent neuroinflammation, metabolic dysregulation, and oxidative stress. Repetitive injuries compound these pathologies and lead to multifocal axonal injuries and long-term functional deficits. Despite the prevalence of mTBIs, the cellular mechanisms that facilitate or prevent recovery following injury remain poorly defined. Here, we extend our previous work on the role of the protein transglutaminase 2 (TG2) in CNS injury and we hypothesize that transcriptional regulation by TG2 restricts metabolic versatility in astrocytes following TBI, thereby impairing neuronal energetic support and worsening pathological outcomes. We utilized an established weight-drop model of repetitive mTBI followed by multi-parametric analysis of TBI pathology in complete TG2 knockout (TG2-\/-) and wild type mice. At 28 days post-injury, TG2-\/- mice showed marked attenuation of TBI pathology, compared to wild type mice, in vulnerable white matter and default mode network (DMN) regions, as assessed by diffusion magnetic resonance imaging (MRI), resting-state functional MRI, and immunohistochemistry. Integrated epigenomic, proteomic, and metabolomic profiling of cortical astrocytes isolated 28 days after injury revealed a pronounced metabolic restriction in wild type astrocytes which was remarkably attenuated in the TG2-\/- mice. This rescue was associated with a de-repression of gene networks involved in glutamate recycling, lipid metabolism, and metabolic homeostasis. Together, these studies provide novel mechanistic insights into the metabolic dysregulation that characterizes persistent TBI pathology, and establish a foundation for evaluating TG2 as a therapeutic target for TBI.<\/jats:p>","DOI":"10.64898\/2026.07.16.738974","type":"posted-content","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:25:16Z","timestamp":1784694316000},"source":"Crossref","is-referenced-by-count":0,"title":["Transglutaminase 2 Deletion Enhances Astrocyte-to-Neuron Metabolic Support and Attenuates Subacute Pathology Following Repetitive Mild Traumatic Brain Injury"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-307X","authenticated-orcid":false,"given":"Thomas","family":"Delgado","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-7548","authenticated-orcid":false,"given":"Tanzil M.","family":"Arefin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA"},{"name":"Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Pagan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-5988","authenticated-orcid":false,"given":"Benjamin H.","family":"Weekley","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Rodwell-Bullock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-2530","authenticated-orcid":false,"given":"Anthony B.","family":"Crum","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-7781","authenticated-orcid":false,"given":"Ian","family":"Maze","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA"},{"name":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA"},{"name":"Howard Hughes Medical Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8639-8413","authenticated-orcid":false,"given":"Paul S.","family":"Brookes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-4491","authenticated-orcid":false,"given":"Julian P.","family":"Meeks","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-0404","authenticated-orcid":false,"given":"Gail V.W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"issue":"1","key":"2026072315253271000_2026.07.16.738974v1.1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/JS9.0000000000001837","article-title":"Global, regional, and national burdens of mild traumatic brain injuries from 1990 to 2019: findings from the Global Burden of Disease Study 2019 - a cross-sectional study","volume":"111","year":"2025","journal-title":"Int J Surg"},{"key":"2026072315253271000_2026.07.16.738974v1.2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.jns17352"},{"key":"2026072315253271000_2026.07.16.738974v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature16035"},{"issue":"1","key":"2026072315253271000_2026.07.16.738974v1.4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13643-023-02284-4","article-title":"Prognostic factors for persistent symptoms in adults with mild traumatic brain injury: an overview of systematic reviews","volume":"12","year":"2023","journal-title":"Syst Rev"},{"key":"2026072315253271000_2026.07.16.738974v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00154-1"},{"issue":"1","key":"2026072315253271000_2026.07.16.738974v1.6","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1038\/s41598-018-25220-2","article-title":"Author Correction: Long-term effects of mild traumatic brain injuries to oculomotor tracking performances and reaction times to simple environmental stimuli","volume":"8","year":"2018","journal-title":"Sci Rep"},{"issue":"8","key":"2026072315253271000_2026.07.16.738974v1.7","doi-asserted-by":"crossref","first-page":"e2223245","DOI":"10.1001\/jamanetworkopen.2022.23245","article-title":"Outcomes in Patients With Mild Traumatic Brain Injury Without Acute Intracranial Traumatic Injury","volume":"5","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2026072315253271000_2026.07.16.738974v1.8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003839"},{"issue":"3","key":"2026072315253271000_2026.07.16.738974v1.9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3233\/JAD-220069","article-title":"Mild Traumatic Brain Injuries and Future Risk of Developing Alzheimer\u2019s Disease: Systematic Review and Meta-Analysis","volume":"87","year":"2022","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"2026072315253271000_2026.07.16.738974v1.10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1001\/jamaneurol.2018.0815","article-title":"Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans","volume":"75","year":"2018","journal-title":"JAMA Neurol"},{"key":"2026072315253271000_2026.07.16.738974v1.11","doi-asserted-by":"crossref","first-page":"1254382","DOI":"10.3389\/fphar.2023.1254382","article-title":"Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model","volume":"14","year":"2023","journal-title":"Front Pharmacol"},{"key":"2026072315253271000_2026.07.16.738974v1.12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826daf50"},{"issue":"1","key":"2026072315253271000_2026.07.16.738974v1.13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40478-021-01161-2","article-title":"Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes","volume":"9","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"2026072315253271000_2026.07.16.738974v1.14","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5663"},{"key":"2026072315253271000_2026.07.16.738974v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.013"},{"key":"2026072315253271000_2026.07.16.738974v1.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0619-8"},{"key":"2026072315253271000_2026.07.16.738974v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.07.006"},{"issue":"12","key":"2026072315253271000_2026.07.16.738974v1.18","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/s42255-025-01404-9","article-title":"The neuron-astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease","volume":"7","year":"2025","journal-title":"Nat Metab"},{"key":"2026072315253271000_2026.07.16.738974v1.19","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00783-4"},{"key":"2026072315253271000_2026.07.16.738974v1.20","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl165"},{"key":"2026072315253271000_2026.07.16.738974v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"issue":"3","key":"2026072315253271000_2026.07.16.738974v1.22","doi-asserted-by":"crossref","first-page":"166992","DOI":"10.1016\/j.bbadis.2023.166992","article-title":"The role of astrocyte in neuroinflammation in traumatic brain injury","volume":"1870","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026072315253271000_2026.07.16.738974v1.23","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa321"},{"key":"2026072315253271000_2026.07.16.738974v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.03.001"},{"key":"2026072315253271000_2026.07.16.738974v1.25","doi-asserted-by":"crossref","unstructured":"Tatsukawa, H. and K. Hitomi , Role of Transglutaminase 2 in Cell Death, Survival, and Fibrosis. Cells, 2021. 10(7).","DOI":"10.3390\/cells10071842"},{"key":"2026072315253271000_2026.07.16.738974v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.023"},{"key":"2026072315253271000_2026.07.16.738974v1.27","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24239"},{"key":"2026072315253271000_2026.07.16.738974v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2018.06.007"},{"key":"2026072315253271000_2026.07.16.738974v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60217-X"},{"key":"2026072315253271000_2026.07.16.738974v1.30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.002505"},{"key":"2026072315253271000_2026.07.16.738974v1.31","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.4.825"},{"key":"2026072315253271000_2026.07.16.738974v1.32","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1909-z"},{"key":"2026072315253271000_2026.07.16.738974v1.33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.20.11991"},{"key":"2026072315253271000_2026.07.16.738974v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.04.018"},{"key":"2026072315253271000_2026.07.16.738974v1.35","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000895"},{"issue":"3","key":"2026072315253271000_2026.07.16.738974v1.36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00441-014-1990-x","article-title":"Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological states","volume":"358","year":"2014","journal-title":"Cell Tissue Res"},{"key":"2026072315253271000_2026.07.16.738974v1.37","doi-asserted-by":"crossref","unstructured":"Emerson, J. , et al., Deletion of Transglutaminase 2 from Mouse Astrocytes Significantly Improves Their Ability to Promote Neurite Outgrowth on an Inhibitory Matrix. Int J Mol Sci, 2023. 24(7).","DOI":"10.3390\/ijms24076058"},{"key":"2026072315253271000_2026.07.16.738974v1.38","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000084"},{"key":"2026072315253271000_2026.07.16.738974v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1024-7"},{"key":"2026072315253271000_2026.07.16.738974v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08371-3"},{"key":"2026072315253271000_2026.07.16.738974v1.41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08409.x"},{"key":"2026072315253271000_2026.07.16.738974v1.42","doi-asserted-by":"crossref","unstructured":"Delgado, T. , et al., Pharmacological Inhibition of Astrocytic Transglutaminase 2 Facilitates the Expression of a Neurosupportive Astrocyte Reactive Phenotype in Association with Increased Histone Acetylation. Biomolecules, 2024. 14(12).","DOI":"10.3390\/biom14121594"},{"key":"2026072315253271000_2026.07.16.738974v1.43","doi-asserted-by":"crossref","unstructured":"Delgado T , J.G., Transglutaminase 2 in Neurological Conditions, in Transglutaminase Fundamentals and Applications, Y. In Zhang, & Simpson, BK, Editor. 2024, Elsevier Publishing. p. 107\u2013122.","DOI":"10.1016\/B978-0-443-19168-8.00005-5"},{"key":"2026072315253271000_2026.07.16.738974v1.44","doi-asserted-by":"crossref","unstructured":"Elahi, A. , et al., Deletion or Inhibition of Astrocytic Transglutaminase 2 Promotes Functional Recovery after Spinal Cord Injury. Cells, 2021. 10(11).","DOI":"10.3390\/cells10112942"},{"key":"2026072315253271000_2026.07.16.738974v1.45","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03177-6"},{"key":"2026072315253271000_2026.07.16.738974v1.46","doi-asserted-by":"crossref","first-page":"1570596","DOI":"10.3389\/fncel.2025.1570596","article-title":"Mitochondria: the hidden engines of traumatic brain injury- driven neurodegeneration","volume":"19","year":"2025","journal-title":"Front Cell Neurosci"},{"key":"2026072315253271000_2026.07.16.738974v1.47","doi-asserted-by":"crossref","unstructured":"Crum, A.B. , et al., Development of a Modified Weight-Drop Apparatus for Closed- Skull, Repetitive Mild Traumatic Brain Injuries in a Mouse Model. eNeuro, 2026. 13(1).","DOI":"10.1523\/ENEURO.0274-25.2025"},{"key":"2026072315253271000_2026.07.16.738974v1.48","doi-asserted-by":"publisher","DOI":"10.1089\/089771501317095241"},{"key":"2026072315253271000_2026.07.16.738974v1.49","unstructured":"Charmant, J. , Kinovea (version 2025.1). [Online], (Available): p. https:\/\/kinovea.readthedocs.io\/en\/latest\/index.html."},{"key":"2026072315253271000_2026.07.16.738974v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.07.002"},{"key":"2026072315253271000_2026.07.16.738974v1.51","doi-asserted-by":"crossref","first-page":"120111","DOI":"10.1016\/j.neuroimage.2023.120111","article-title":"Towards reliable reconstruction of the mouse brain corticothalamic connectivity using diffusion MRI","volume":"273","year":"2023","journal-title":"Neuroimage"},{"issue":"5","key":"2026072315253271000_2026.07.16.738974v1.52","doi-asserted-by":"crossref","first-page":"e2316601","DOI":"10.1001\/jamanetworkopen.2023.16601","article-title":"Longitudinal Associations of Clinical and Biochemical Head Injury Biomarkers With Head Impact Exposure in Adolescent Football Players","volume":"6","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"13-14","key":"2026072315253271000_2026.07.16.738974v1.53","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1089\/neu.2023.0307","article-title":"A Pilot Study Investigating the Use of Serum Glial Fibrillary Acidic Protein to Monitor Changes in Brain White Matter Integrity After Repetitive Head Hits During a Single Collegiate Football Game","volume":"41","year":"2024","journal-title":"J Neurotrauma"},{"issue":"1","key":"2026072315253271000_2026.07.16.738974v1.54","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1038\/s42003-025-09138-w","article-title":"Astrocyte activation persists one year after TBI: a dynamic shift from inflammation to neurodegeneration","volume":"8","year":"2025","journal-title":"Commun Biol"},{"key":"2026072315253271000_2026.07.16.738974v1.55","doi-asserted-by":"crossref","first-page":"821885","DOI":"10.3389\/fncel.2022.821885","article-title":"Mild Traumatic Brain Injury-Induced Disruption of the Blood-Brain Barrier Triggers an Atypical Neuronal Response","volume":"16","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"2026072315253271000_2026.07.16.738974v1.56","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx951"},{"key":"2026072315253271000_2026.07.16.738974v1.57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206458109"},{"key":"2026072315253271000_2026.07.16.738974v1.58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.802074"},{"key":"2026072315253271000_2026.07.16.738974v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.08.004"},{"key":"2026072315253271000_2026.07.16.738974v1.60","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021636102735"},{"key":"2026072315253271000_2026.07.16.738974v1.61","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9161-4"},{"key":"2026072315253271000_2026.07.16.738974v1.62","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0274-x"},{"key":"2026072315253271000_2026.07.16.738974v1.63","doi-asserted-by":"crossref","first-page":"702179","DOI":"10.3389\/fcell.2021.702179","article-title":"Axonal Regeneration by Glycosaminoglycan","volume":"9","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026072315253271000_2026.07.16.738974v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.1004.1001"},{"key":"2026072315253271000_2026.07.16.738974v1.65","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111901"},{"issue":"8","key":"2026072315253271000_2026.07.16.738974v1.66","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s42255-023-00835-6","article-title":"Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition","volume":"5","year":"2023","journal-title":"Nat Metab"},{"key":"2026072315253271000_2026.07.16.738974v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.002"},{"key":"2026072315253271000_2026.07.16.738974v1.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03539-7"},{"key":"2026072315253271000_2026.07.16.738974v1.69","doi-asserted-by":"crossref","unstructured":"Padalko, V. , F. Posnik , and M. Adamczyk , Mitochondrial Aconitase and Its Contribution to the Pathogenesis of Neurodegenerative Diseases. Int J Mol Sci, 2024. 25(18).","DOI":"10.3390\/ijms25189950"},{"key":"2026072315253271000_2026.07.16.738974v1.70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11168"},{"key":"2026072315253271000_2026.07.16.738974v1.71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094734"},{"key":"2026072315253271000_2026.07.16.738974v1.72","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000740"},{"key":"2026072315253271000_2026.07.16.738974v1.73","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120748"},{"key":"2026072315253271000_2026.07.16.738974v1.74","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv047"},{"key":"2026072315253271000_2026.07.16.738974v1.75","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fnmol.2020.00126","article-title":"RNA Binding Motif 5 (RBM5) in the CNS- Moving Beyond Cancer to Harness RNA Splicing to Mitigate the Consequences of Brain Injury","volume":"13","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"2026072315253271000_2026.07.16.738974v1.76","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade0027"},{"key":"2026072315253271000_2026.07.16.738974v1.77","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.canlet.2020.04.015","article-title":"Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor","volume":"483","year":"2020","journal-title":"Cancer Lett"},{"key":"2026072315253271000_2026.07.16.738974v1.78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004526"},{"key":"2026072315253271000_2026.07.16.738974v1.79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809794200"},{"issue":"2","key":"2026072315253271000_2026.07.16.738974v1.80","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11064-025-04345-7","article-title":"Yin Yang 1: Function, Mechanisms, and Glia","volume":"50","year":"2025","journal-title":"Neurochem Res"},{"key":"2026072315253271000_2026.07.16.738974v1.81","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"2026072315253271000_2026.07.16.738974v1.82","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14159"},{"key":"2026072315253271000_2026.07.16.738974v1.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.014"},{"key":"2026072315253271000_2026.07.16.738974v1.84","doi-asserted-by":"crossref","unstructured":"Skene, P.J. and S. Henikoff , An efficient targeted nuclease strategy for high- resolution mapping of DNA binding sites. Elife, 2017. 6.","DOI":"10.7554\/eLife.21856"},{"key":"2026072315253271000_2026.07.16.738974v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.12.021"},{"key":"2026072315253271000_2026.07.16.738974v1.86","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"2026072315253271000_2026.07.16.738974v1.87","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"2026072315253271000_2026.07.16.738974v1.88","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku365"},{"key":"2026072315253271000_2026.07.16.738974v1.89","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"2026072315253271000_2026.07.16.738974v1.90","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"2026072315253271000_2026.07.16.738974v1.91","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"2026072315253271000_2026.07.16.738974v1.92","doi-asserted-by":"crossref","unstructured":"Xie, Z. , et al., Gene Set Knowledge Discovery with Enrichr. Curr Protoc, 2021. 1(3): p. e90.","DOI":"10.1002\/cpz1.90"},{"key":"2026072315253271000_2026.07.16.738974v1.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.11.008"},{"key":"2026072315253271000_2026.07.16.738974v1.94","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbp059"},{"key":"2026072315253271000_2026.07.16.738974v1.95","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2017.0486"},{"key":"2026072315253271000_2026.07.16.738974v1.96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601640113"},{"key":"2026072315253271000_2026.07.16.738974v1.97","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910030602"},{"key":"2026072315253271000_2026.07.16.738974v1.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117094"},{"issue":"4","key":"2026072315253271000_2026.07.16.738974v1.99","doi-asserted-by":"crossref","first-page":"e70060","DOI":"10.1111\/gbb.70060","article-title":"Dissecting the Strain and Sex Specific Connectome Signatures of Unanesthetized C57BL\/6J and DBA\/2J Mice Using Magnetic Resonance Imaging","volume":"25","year":"2026","journal-title":"Genes Brain Behav"},{"key":"2026072315253271000_2026.07.16.738974v1.100","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"issue":"22","key":"2026072315253271000_2026.07.16.738974v1.101","first-page":"e4221","article-title":"Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging","volume":"11","year":"2021","journal-title":"Bio Protoc"},{"issue":"2","key":"2026072315253271000_2026.07.16.738974v1.102","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41684-023-01320-z","article-title":"Open-source versatile 3D-print animal conditioning platform design for in vivo preclinical brain imaging in awake mice and anesthetized mice and rats","volume":"53","year":"2024","journal-title":"Lab Anim (NY"},{"key":"2026072315253271000_2026.07.16.738974v1.103","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2005.08.004"},{"key":"2026072315253271000_2026.07.16.738974v1.104","doi-asserted-by":"crossref","first-page":"110348","DOI":"10.1016\/j.neuropharm.2025.110348","article-title":"Sex-specific signatures of GLP-1 and amylin on resting state brain activity and functional connectivity in awake rats","volume":"269","year":"2025","journal-title":"Neuropharmacology"},{"key":"2026072315253271000_2026.07.16.738974v1.105","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.012"},{"key":"2026072315253271000_2026.07.16.738974v1.106","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.16.738974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:25:45Z","timestamp":1784845545000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.07.16.738974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":106,"URL":"https:\/\/doi.org\/10.64898\/2026.07.16.738974","relation":{},"subject":[],"published":{"date-parts":[[2026,7,21]]},"subtype":"preprint"}}