{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:42:32Z","timestamp":1785400952150,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,20]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":51,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["T32MH017119"],"award-info":[{"award-number":["T32MH017119"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32MH125786"],"award-info":[{"award-number":["T32MH125786"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["K01MH119603"],"award-info":[{"award-number":["K01MH119603"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["U01MH110925"],"award-info":[{"award-number":["U01MH110925"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01MH106595"],"award-info":[{"award-number":["R01MH106595"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01MH133268"],"award-info":[{"award-number":["R01MH133268"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["W81XWH-22-2-0078"],"award-info":[{"award-number":["W81XWH-22-2-0078"]}],"id":[{"id":"https:\/\/ror.org\/0447fe631","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/03cd02q50","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018727","name":"One Mind","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018727","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Mayday Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) often account for a low amount of variance. Ancestry-related differences in PRS scale and variance limit cross-group comparisons. This methodological challenge further complicates gene-by-environment (GxE) analyses, given that socioenvironmental exposures are inequitably distributed across ethnoracial groups. We constructed an ancestry-calibrated polygenic risk score (AC-PRS) for PTSD in the largest longitudinal study of trauma survivors to date and investigated GxE interactions.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Recent trauma survivors (N=1,801) provided a blood specimen for genotyping. Six PTSD trajectories were previously identified from PTSD Checklist for DSM-5 (PCL-5) scores at 2-weeks, 8-weeks, 3-months, and 6-months post-trauma. Greenspace (normalized difference vegetation index [NDVI) and socioeconomic disadvantage (area deprivation index [ADI]) were derived from residential addresses. Logistic regressions examined interactions between newly developed AC-PRS and neighborhood factors on trajectories after adjusting for sociodemographic and trauma-related covariates. Secondary linear models considered GxE interactions on 6-month PCL-5 scores.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    AC-PRS performed well across ethnoracial groups, explaining significant variability in PTSD trajectories (R\n                    <jats:sup>2<\/jats:sup>\n                    =.053). ADI moderated the association between AC-PRS and the likelihood of assignment in a high nonremitting trajectory of PTSD symptoms and severity of symptoms at 6-months (\n                    <jats:italic>ps<\/jats:italic>\n                    &lt; .05). There were no NDVI x AC-PRS interactions in any models.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AC-PRS captures genetic risk for PTSD in admixed trauma survivors, demonstrating good discrimination between nonremitting and resilient courses of PTSD. However, neighborhood disadvantage may modify utility of PRS for PTSD, warranting careful consideration when applying these scores across contexts.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.17.26358149","type":"posted-content","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:45:12Z","timestamp":1784562312000},"source":"Crossref","is-referenced-by-count":0,"title":["Ancestry-Calibrated Polygenic Risk Scores Predict PTSD Trajectories in Recent Trauma Survivors and Interact with Neighborhood Resources"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-7836","authenticated-orcid":false,"given":"E. Kate","family":"Webb","sequence":"first","affiliation":[{"name":"Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA"},{"name":"Duke University School of Medicine, Department of Psychiatry, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-1697","authenticated-orcid":false,"given":"Aarti","family":"Jajoo","sequence":"additional","affiliation":[{"name":"Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA"},{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5631-3006","authenticated-orcid":false,"given":"Vijetha","family":"Balakundi","sequence":"additional","affiliation":[{"name":"Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA"},{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA"},{"name":"Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-1786","authenticated-orcid":false,"given":"Mohammad S.E.","family":"Sendi","sequence":"additional","affiliation":[{"name":"Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA"},{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA"},{"name":"Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, 30302, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-7655","authenticated-orcid":false,"given":"Karestan C.","family":"Koenen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA"},{"name":"Department of Epidemiology, Harvard T.H. 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