{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:59:32Z","timestamp":1785189572683,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,22]]},"group-title":"Neuroscience","reference-count":110,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>\n                    Environmental factors are increasingly implicated in the etiology of autism spectrum disorder (ASD). Polybrominated diphenyl ethers (PBDEs) are anthropogenic toxicants added as flame retardants to consumer products that have become ubiquitous environmental contaminants and disrupt thyroid hormone (TH) and neuroendocrine systems. We have previously shown that developmental PBDE exposure produces ASD-like traits with involvement of oxytocin (OXT)-thyroid hormone signaling.\n                    <jats:italic>Limosilactobacillus reuteri<\/jats:italic>\n                    (LR), a widely used probiotic bacterium, has been shown to improve social functioning and increase TH and OXT levels in murine models. Therefore, we tested the hypothesis that LR supplementation (LR) prevents PBDE-induced deficits in socioemotional behavior with concomitant modulation of TH signaling genes on hypothalamic OXT neurons.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>\n                    C57BL\/6N mouse offspring were exposed to a commercial penta-mixture of PBDE congeners, DE-71, at an environmentally realistic concentration, 0.1 mg\/kg\/d (DE-71), or to corn oil vehicle (VEH\/CON) via their mothers during gestation and lactation. Offspring received supplementation with LR ATCC PTA 6475 (10\n                    <jats:sup>7<\/jats:sup>\n                    -10\n                    <jats:sup>8<\/jats:sup>\n                    CFU\/mL, po) indirectly via the dam or continuation directly through adulthood. Unsupplemented controls were given saline.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Fecal microbiome analysis in offspring confirmed colonization of LR at postnatal day (P) 40 and depletion by P104. LR treatment increased plasma total thyroxine in DE-71 and plasma OXT in VEH\/CON dams. In DE-71 offspring of both sexes, LR normalized deficient scores on social novelty preference and emotional recognition in adult females and males and deficient long-term social recognition memory (SRM) in adult DE-71 females; DE-71 males were normal. Reduced olfactory dishabituation between two social odors may partly explain the compromised socioemotional behavior produced by DE-71 in an LR-dependent manner. Multiplex RNA\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization performed on immunoreactive OXT-ergic neurons in the paraventricular hypothalamic nucleus (PVH) revealed significant upregulation of TH transporter monocarboxylate transporter 8 (\n                    <jats:italic>Mct8<\/jats:italic>\n                    ) and downregulation of iodothyronine deiodinase 3 (\n                    <jats:italic>Dio3<\/jats:italic>\n                    ) in DE-71 relative to VEH\/CON females. This toxicant-induced reprogramming was prevented by probiotic treatment. DE-71 males expressed reduction in\n                    <jats:italic>Mct8<\/jats:italic>\n                    and\n                    <jats:italic>Dio3<\/jats:italic>\n                    transcripts on OXT-ergic neurons with minimal LR protection. In the female supraoptic nucleus (SON),\n                    <jats:italic>Mct8<\/jats:italic>\n                    and\n                    <jats:italic>Dio3<\/jats:italic>\n                    were downregulated by DE-71 and normalized in DE-71+LR; there were no group effects on transcript levels in male SON. Results of fecal 16S rRNA sequencing indicated reduced \u03b1-diversity and altered \u03b2-diversity in the gut bacterial community of female but not male DE-71 exposed offspring; most changes were correctable by LR. Alterations in taxa-level abundance caused by DE-71 and reversed by LR were observed in both sexes. These involved\n                    <jats:italic>Bifidobacterium, Coprococcus, Desulfovibrio, Oscillospira<\/jats:italic>\n                    , and Peptococcaceae in females and Desulfovibrionaceae,\n                    <jats:italic>Rikenella<\/jats:italic>\n                    , and\n                    <jats:italic>Turicibacter<\/jats:italic>\n                    in males. Exposed dams showed no detriment in \u03b1- and \u03b2-diversity while showing reduced abundance of several Firmicutes and Proteobacteria taxa that could be rescued by LR. The relative abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    was upregulated in DE-71 males and DE-71+LR males and dams.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>\n                    These results indicate that developmental probiotic supplementation effectively mitigated organohalogen-induced ASD-like deficits in socioemotional behavior and partially corrected dysbiosis of gut bacterial communities in exposed offspring of both sexes. Concomitantly, PBDEs altered the expression of TH regulatory genes\n                    <jats:italic>Mct8<\/jats:italic>\n                    and\n                    <jats:italic>Dio3<\/jats:italic>\n                    in PVH OXT neurons in a sex-dependent manner, suggesting that TH regulation of OXT neuroendocrine cells may modulate the emergence of toxicant-induced ASD-relevant behavior. While LR reinstated normal behavioral outcomes in PBDE-exposed offspring of both sexes, coincident normalization of hypothalamic TH signaling transcripts occurred more broadly in females, indicating the existence of unique parallel processes influencing the preventive effects of LR on ASD-relevant behavioral deficits in both sexes.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.18.739173","type":"posted-content","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:10:14Z","timestamp":1784776214000},"source":"Crossref","is-referenced-by-count":0,"title":["Social and neuroendocrine phenotypes reprogrammed by endocrine-disrupting chemicals can be mitigated by\n                  <i>Limosilactobacillus reuteri<\/i>\n                  modulation of the gut microbiome\u2013thyroid\u2013oxytocin axis"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-6618","authenticated-orcid":false,"given":"Elena V.","family":"Kozlova","sequence":"first","affiliation":[{"name":"Department of Molecular Cell and Systems, University of California, Riverside, CA"},{"name":"Neuroscience Graduate Program, University of California, Riverside, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-6265","authenticated-orcid":false,"given":"Maximillian E.","family":"Denys","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell and Systems, University of California, Riverside, CA"},{"name":"School of Medicine, University of California, Riverside, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-3770","authenticated-orcid":false,"given":"Anthony E.","family":"Bishay","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell and Systems, University of California, Riverside, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3264-8138","authenticated-orcid":false,"given":"Elyza A.","family":"Do","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, Riverside, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lui","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, Riverside, CA, USA"},{"name":"National Institution of Drug Clinical Trial, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3003-0665","authenticated-orcid":false,"given":"Crystal N.","family":"Luna","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell and Systems, University of California, Riverside, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1023-5204","authenticated-orcid":false,"given":"Artha","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell and Systems, University of California, Riverside, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8273-8653","authenticated-orcid":false,"given":"Varadh","family":"Piamthai","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, Riverside, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansel","family":"Hsiao","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, Riverside, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-4179","authenticated-orcid":false,"given":"Margarita","family":"Curras-Collazo","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell and Systems, University of California, Riverside, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026072714154777000_2026.07.18.739173v1.1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b07032"},{"key":"2026072714154777000_2026.07.18.739173v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50592-0"},{"key":"2026072714154777000_2026.07.18.739173v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.036"},{"key":"2026072714154777000_2026.07.18.739173v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.10.007"},{"key":"2026072714154777000_2026.07.18.739173v1.5","unstructured":"American Psychiatric Association. 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