{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:58:30Z","timestamp":1785430710660,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,20]]},"group-title":"Immunology","reference-count":65,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"CAPNET, French government","award":["APHP 220959"],"award-info":[{"award-number":["APHP 220959"]}]},{"award":["ANR-22-CE15-0047-01"],"award-info":[{"award-number":["ANR-22-CE15-0047-01"]}],"id":[{"id":"https:\/\/ror.org\/00rbzpz17","id-type":"ROR","asserted-by":"publisher"}]},{"award":["ANR-24-CHBS-0003"],"award-info":[{"award-number":["ANR-24-CHBS-0003"]}],"id":[{"id":"https:\/\/ror.org\/00rbzpz17","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Immune imprinting profoundly shapes antibody responses to breakthrough infections and vaccination against evolving endemic viruses. Current vaccine design primarily focuses on antigen sequence and variant mutations but rarely consider the structural context in which these antigens are being recognized. In this study, we make use of the longitudinal analysis of memory B cell (MBC) responses in boosted individuals enrolled in the COVIBOOST clinical trial to provide a proof of principle that variant-specific conformational dynamics can impact MBC recruitment and protective antibody responses, independently of epitope conservation. Combining functional characterization of MBC-derived monoclonal antibodies, repertoire analysis, epitope mapping and\n                  <jats:italic>in silico<\/jats:italic>\n                  structural modeling of epitope accessibility, we found that the adjuvanted B.1.351 spike vaccine preferentially recalled MBCs targeting exposed receptor-binding domain neutralizing epitopes. This preferential recruitment arises from the more restricted conformational dynamics of the B.1.351 spike compared to the ancestral Hu-1 spike, leading to increased masking of class 4 and 5 cryptic RBD epitopes. These findings demonstrate that antigen conformational dynamics can be leveraged to redirect pre-existing immunity toward neutralizing epitopes upon boost immunization.\n                <\/jats:p>","DOI":"10.64898\/2026.07.18.739204","type":"posted-content","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:05:17Z","timestamp":1784606717000},"source":"Crossref","is-referenced-by-count":0,"title":["Variant-specific spike conformational dynamics shape memory B cell selection during recall"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-036X","authenticated-orcid":false,"given":"Manon","family":"Broutin","sequence":"first","affiliation":[{"name":"Institut Necker Enfants Malades, INSERM U1151\/CNRS UMR 8253, Auto-Immune and Immune B cells, Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris-Est-Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-8689","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Sokal","sequence":"additional","affiliation":[{"name":"Institut Necker Enfants Malades, INSERM U1151\/CNRS UMR 8253, Auto-Immune and Immune B cells, Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris-Est-Cr\u00e9teil, France"},{"name":"Service de M\u00e9decine interne, H\u00f4pital Beaujon, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 de Paris Cit\u00e9, Clichy, France"},{"name":"Service de M\u00e9decine Interne, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris-Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6715-633X","authenticated-orcid":false,"given":"Alice","family":"Dejoux","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, INSERM UMR1222, Unit of Antibodies in Therapy and Pathology, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-9954","authenticated-orcid":false,"given":"Delphine","family":"Planas","sequence":"additional","affiliation":[{"name":"Virus and Immunity Unit, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-5904","authenticated-orcid":false,"given":"Matthias","family":"Vanderkerken","sequence":"additional","affiliation":[{"name":"Institut Necker Enfants Malades, INSERM U1151\/CNRS UMR 8253, Auto-Immune and Immune B cells, Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris-Est-Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, CNRS UMR 3569, Unit\u00e9 de Virologie Structurale, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-6780","authenticated-orcid":false,"given":"Imane","family":"Azzaoui","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris-Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France"},{"name":"INSERM U955, \u00e9quipe 2. 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