{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:05:06Z","timestamp":1785323106059,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,25]]},"group-title":"Physiology","reference-count":67,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health & Human Development","doi-asserted-by":"crossref","award":["R01HD111479"],"award-info":[{"award-number":["R01HD111479"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health & Human Development","doi-asserted-by":"crossref","award":["R00HD090301"],"award-info":[{"award-number":["R00HD090301"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Extracellular matrix (ECM) remodeling and angiogenesis are essential processes underlying endometrial decidualization during embryo implantation. Fibrillar collagens, the major structural components of the ECM, form the architectural framework of the decidua and undergo dynamic reorganization during this process. However, the functional role of type V collagen\u2014a key regulator of collagen fibrillogenesis\u2014 remains undefined. Here, we demonstrate that\n                  <jats:italic>Col5a1<\/jats:italic>\n                  is highly expressed in decidual stromal and endothelial cells of the mouse uterus. Conditional deletion of\n                  <jats:italic>Col5a1<\/jats:italic>\n                  leads to progressive uterine hemorrhage beginning at gestation day 8, culminating in complete embryo resorption and pregnancy loss by day 12.\n                  <jats:italic>Col5a1<\/jats:italic>\n                  -deficient decidua exhibits severe structural distortion, marked disorganization of fibrillar collagen, shallow and misdirected embryo invasion, and profound disruption of decidual angiogenesis and vascular network formation. Transcriptomic profiling further reveals distinct gene expression signatures and signaling pathways regulated by COL5A1 in the decidua. Collectively, these findings identify type V collagen as a critical ECM regulator required for maintaining decidual integrity, supporting angiogenesis, and ensuring successful pregnancy.\n                <\/jats:p>","DOI":"10.64898\/2026.07.22.740039","type":"posted-content","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:31:35Z","timestamp":1785130295000},"source":"Crossref","is-referenced-by-count":0,"title":["Type V Collagen Controls Decidual Extracellular Matrix Organization and Angiogenesis During Embryo Implantation"],"prefix":"10.64898","author":[{"given":"Mona","family":"Gebril","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Kinneston","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimi","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Boyd","sequence":"additional","affiliation":[{"name":"Vermont Integrative Genomics Resource, University of Vermont, Burlington, VT, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Lydon","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmugasundaram","family":"Nallasamy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026072903401082000_2026.07.22.740039v1.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra000763"},{"key":"2026072903401082000_2026.07.22.740039v1.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807283190401"},{"key":"2026072903401082000_2026.07.22.740039v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00228-z"},{"key":"2026072903401082000_2026.07.22.740039v1.4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00160"},{"key":"2026072903401082000_2026.07.22.740039v1.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706546114"},{"key":"2026072903401082000_2026.07.22.740039v1.6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114092"},{"key":"2026072903401082000_2026.07.22.740039v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3012"},{"key":"2026072903401082000_2026.07.22.740039v1.8","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1045"},{"key":"2026072903401082000_2026.07.22.740039v1.9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242989"},{"key":"2026072903401082000_2026.07.22.740039v1.10","doi-asserted-by":"crossref","unstructured":"Favaro R , Abrahamsohn PA , Zorn MT . Decidualization and endometrial extracellular matrix remodeling. In: Croy BA , Yamada AT , DeMayo FJ , Adamson SL , editors. The Guide to Investigation of Mouse Pregnancy. 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