{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:59:50Z","timestamp":1785351590944,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,27]]},"group-title":"Epidemiology","reference-count":15,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["JP24dk0207068"],"award-info":[{"award-number":["JP24dk0207068"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["JP25dk0207075"],"award-info":[{"award-number":["JP25dk0207075"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP24K10653"],"award-info":[{"award-number":["JP24K10653"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP25K19014"],"award-info":[{"award-number":["JP25K19014"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Electronic health records linked documented glucosamine use to faster progression from mild cognitive impairment (MCI) to Alzheimer\u2019s disease (AD) and poorer survival after dementia. We examined these associations in the National Alzheimer\u2019s Coordinating Center cohort and compared glucosamine with other supplement records captured in the same medication fields. The estimate for progression to primary AD dementia was in the same risk direction as the original finding, but similar estimates were observed for multivitamin\/broad vitamin and calcium\/vitamin D records. Among participants with dementia, glucosamine records were not associated with higher adjusted mortality, although death-data limitations reduce certainty. These findings do not address the experimental mechanism, but show that a glucosamine record alone does not establish a glucosamine-specific clinical effect.<\/jats:p>","DOI":"10.64898\/2026.07.23.26358748","type":"posted-content","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:15:19Z","timestamp":1785172519000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparator supplement patterns qualify the clinical interpretation of an EHR-derived glucosamine signal in Alzheimer\u2019s disease"],"prefix":"10.64898","author":[{"given":"Saki","family":"Nakashima","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"},{"name":"Unit for Early and Exploratory Development, The University of Tokyo Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Unit for Early and Exploratory Development, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"Dementia Inclusion and Therapeutics, The University of Tokyo Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Unit for Early and Exploratory Development, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"Dementia Inclusion and Therapeutics, The University of Tokyo Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Satake","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwatsubo","sequence":"additional","affiliation":[{"name":"Dementia Inclusion and Therapeutics, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"National Center of Neurology and Psychiatry, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026072911301218000_2026.07.23.26358748v1.1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s42255-026-01538-4","article-title":"Hyperglycosylation is a metabolic driver of Alzheimer\u2019s disease","volume":"8","year":"2026","journal-title":"Nat. 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