{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:11:19Z","timestamp":1785431479558,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,24]]},"group-title":"Neuroscience","reference-count":26,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R01MH093727"],"award-info":[{"award-number":["R01MH093727"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01NS142192"],"award-info":[{"award-number":["R01NS142192"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>The neural \u2018chain of events\u2019 necessary for movement initiation is poorly understood, particularly for endogenous actions that are self-timed. Here, we introduce a new task that requires mice to self-initiate a movement with high temporal precision in the absence of external \u2018go\u2019 signals. Brief, precisely timed flashes of optogenetic photoinhibition reveal that movement initiation is causally driven by rapid sequential recruitment of neurons in prefrontal cortex and lateral cerebellum.<\/jats:p>","DOI":"10.64898\/2026.07.23.739940","type":"posted-content","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:30:20Z","timestamp":1784892620000},"source":"Crossref","is-referenced-by-count":0,"title":["Self-timed movement initiation requires rapid sequential coordination of circuits in prefrontal cortex and cerebellum"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-6392","authenticated-orcid":false,"given":"Mikhail V.","family":"Monakhov","sequence":"first","affiliation":[{"name":"Neuroscience Department, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-5337","authenticated-orcid":false,"given":"Gregory J.","family":"Wojaczynski","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier F.","family":"Medina","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026072802050567000_2026.07.23.739940v1.1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr391"},{"key":"2026072802050567000_2026.07.23.739940v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.02.006"},{"key":"2026072802050567000_2026.07.23.739940v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.12.035"},{"key":"2026072802050567000_2026.07.23.739940v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0633-x"},{"key":"2026072802050567000_2026.07.23.739940v1.5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-072116-031033"},{"key":"2026072802050567000_2026.07.23.739940v1.6","first-page":"570","article-title":"The basal ganglia and the initiation of movement","volume":"146","year":"1990","journal-title":"Rev Neurol (Paris"},{"key":"2026072802050567000_2026.07.23.739940v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.045"},{"key":"2026072802050567000_2026.07.23.739940v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00307-0"},{"key":"2026072802050567000_2026.07.23.739940v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.05.016"},{"key":"2026072802050567000_2026.07.23.739940v1.10","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.celrep.2018.04.035","article-title":"Cerebellar Shaping of Motor Cortical Firing Is Correlated with Timing of Motor Actions","volume":"23","year":"2018","journal-title":"Cell reports"},{"key":"2026072802050567000_2026.07.23.739940v1.11","doi-asserted-by":"crossref","first-page":"108537","DOI":"10.1016\/j.celrep.2020.108537","article-title":"Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation","volume":"33","year":"2020","journal-title":"Cell reports"},{"key":"2026072802050567000_2026.07.23.739940v1.12","doi-asserted-by":"publisher","DOI":"10.1080\/14734220309410"},{"key":"2026072802050567000_2026.07.23.739940v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.11.007"},{"key":"2026072802050567000_2026.07.23.739940v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.013"},{"key":"2026072802050567000_2026.07.23.739940v1.15","doi-asserted-by":"crossref","unstructured":"Gaffield, M. 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Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice. eLife 11, (2022).","DOI":"10.7554\/eLife.71464"},{"key":"2026072802050567000_2026.07.23.739940v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.04.039"},{"key":"2026072802050567000_2026.07.23.739940v1.17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1698-13.2013"},{"key":"2026072802050567000_2026.07.23.739940v1.18","doi-asserted-by":"crossref","first-page":"799581","DOI":"10.3389\/fncir.2022.799581","article-title":"Neural Substrates and Models of Omission Responses and Predictive Processes","volume":"16","year":"2022","journal-title":"Front Neural Circuits"},{"key":"2026072802050567000_2026.07.23.739940v1.19","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00133"},{"key":"2026072802050567000_2026.07.23.739940v1.20","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1038\/s41598-019-39812-z","article-title":"Hit the missing stimulus\u201d. A simultaneous EEG-fMRI study to localize the generators of endogenous ERPs in an omitted target paradigm","volume":"9","year":"2019","journal-title":"Sci Rep"},{"key":"2026072802050567000_2026.07.23.739940v1.21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00689.2011"},{"key":"2026072802050567000_2026.07.23.739940v1.22","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.neuron.2021.06.027","article-title":"When the cerebellum holds the starting gun","volume":"109","year":"2021","journal-title":"Neuron"},{"key":"2026072802050567000_2026.07.23.739940v1.23","doi-asserted-by":"crossref","unstructured":"Kunimatsu, J. , Suzuki, T. W. , Ohmae, S. & Tanaka, M . Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing. eLife 7, (2018).","DOI":"10.7554\/eLife.35676"},{"key":"2026072802050567000_2026.07.23.739940v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01560-9"},{"key":"2026072802050567000_2026.07.23.739940v1.25","doi-asserted-by":"crossref","unstructured":"Kameda, M. , Ohmae, S. & Tanaka, M . Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum. eLife 8, (2019).","DOI":"10.7554\/eLife.48702"},{"key":"2026072802050567000_2026.07.23.739940v1.26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2221641120"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.23.739940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:05:16Z","timestamp":1785229516000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.07.23.739940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":26,"URL":"https:\/\/doi.org\/10.64898\/2026.07.23.739940","relation":{},"subject":[],"published":{"date-parts":[[2026,7,24]]},"subtype":"preprint"}}