{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:40:36Z","timestamp":1787236836465,"version":"build-2736575974"},"posted":{"date-parts":[[2026,7,27]]},"group-title":"Cardiovascular Medicine","reference-count":42,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["FS\/IPBSRF\/22\/27059"],"award-info":[{"award-number":["FS\/IPBSRF\/22\/27059"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RG\/F\/24\/110138"],"award-info":[{"award-number":["RG\/F\/24\/110138"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RE\/24\/130023"],"award-info":[{"award-number":["RE\/24\/130023"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["CH\/F\/24\/90015"],"award-info":[{"award-number":["CH\/F\/24\/90015"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NH\/F\/23\/70013"],"award-info":[{"award-number":["NH\/F\/23\/70013"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["FS\/CFLF\/26\/506005"],"award-info":[{"award-number":["FS\/CFLF\/26\/506005"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RG\/F\/22\/110078"],"award-info":[{"award-number":["RG\/F\/22\/110078"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["BBC\/F\/21\/220106"],"award-info":[{"award-number":["BBC\/F\/21\/220106"]}],"id":[{"id":"https:\/\/ror.org\/02wdwnk04","id-type":"ROR","asserted-by":"publisher"}]},{"award":["MC-A658-5TY00"],"award-info":[{"award-number":["MC-A658-5TY00"]}],"id":[{"id":"https:\/\/ror.org\/03x94j517","id-type":"ROR","asserted-by":"publisher"}]},{"award":["MC_UP_1605\/13"],"award-info":[{"award-number":["MC_UP_1605\/13"]}],"id":[{"id":"https:\/\/ror.org\/03x94j517","id-type":"ROR","asserted-by":"publisher"}]},{"award":["EP\/Z531297\/1"],"award-info":[{"award-number":["EP\/Z531297\/1"]}],"id":[{"id":"https:\/\/ror.org\/0439y7842","id-type":"ROR","asserted-by":"publisher"}]},{"award":["21JTA"],"award-info":[{"award-number":["21JTA"]}],"id":[{"id":"https:\/\/ror.org\/03ntprd85","id-type":"ROR","asserted-by":"publisher"}]},{"award":["07469\/Z\/15\/Z"],"award-info":[{"award-number":["07469\/Z\/15\/Z"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["200990\/A\/16\/Z"],"award-info":[{"award-number":["200990\/A\/16\/Z"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Right ventricular (RV) trabeculation may reflect adaptation to loading conditions and imprinting of early devel-opmental processes, yet its genetic determinants and clinical relevance in adults remain poorly understood. In contrast to the left ventricle, the RV has distinct developmental origins, geometry and loading conditions, suggesting chamber-specific mechanisms of trabecular remodelling. Using deep learning\u2013based image segmen-tation and fractal dimension analysis, we quantified RV trabecular complexity in diastole and systole in 48,118 UK Biobank participants with genetic data. RV trabecular morphology was associated with systolic function, as well as cardiometabolic and respiratory conditions. Genetic analyses across the allele frequency spectrum identified 52 common loci and 45 genes with a burden of protein-altering variants, implicating sarcomeric function, cytoskeletal organisation, and early cardiac patterning. Although many loci showed shared effects across both ventricles, we also identified RV-specific genetic associations linked to congenital heart disease and respiratory phenotypes. Notably, associations at\n                  <jats:italic>CFTR<\/jats:italic>\n                  suggest a connection between airway-associated mucus regulation and RV remodelling, whereas\n                  <jats:italic>MYH6<\/jats:italic>\n                  implicates sarcomeric and developmental mechanisms in adult RV patterning. Together, these findings establish RV trabeculation as a trait that captures both shared and chamber-specific mechanisms relevant to cardiovascular health and disease.\n                <\/jats:p>","DOI":"10.64898\/2026.07.24.26358843","type":"posted-content","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:00:17Z","timestamp":1785171617000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic regulation of right ventricular trabeculation identifies developmental and cardiopulmonary pathways"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-6906","authenticated-orcid":false,"given":"Kathryn A","family":"McGurk","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"MRC Laboratory of Medical Sciences and Institute of Clinical Sciences, Imperial College London, London, UK"},{"name":"Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-1083","authenticated-orcid":false,"given":"Jan","family":"Sedlacik","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Medical Sciences and Institute of Clinical Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2688-6271","authenticated-orcid":false,"given":"Riyad","family":"Janan","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"MRC Laboratory of Medical Sciences and Institute of Clinical Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-7078","authenticated-orcid":false,"given":"Arunashis","family":"Sau","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"Department of Cardiology, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-4368","authenticated-orcid":false,"given":"Fu Siong","family":"Ng","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"Department of Cardiology, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-7698","authenticated-orcid":false,"given":"Wenjia","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Computing, Imperial College London, London, UK"},{"name":"Department of Brain Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-5880","authenticated-orcid":false,"given":"James S","family":"Ware","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"MRC Laboratory of Medical Sciences and Institute of Clinical Sciences, Imperial College London, London, UK"},{"name":"Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, US"},{"name":"Department of Cardiology, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Royal Brompton & Harefield Hospitals, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0691-0270","authenticated-orcid":false,"given":"Declan P","family":"O\u2019Regan","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Medical Sciences and Institute of Clinical Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026082007100899000_2026.07.24.26358843v2.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2008.02.007"},{"key":"2026082007100899000_2026.07.24.26358843v2.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0110-6"},{"key":"2026082007100899000_2026.07.24.26358843v2.3","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-023-10459-6"},{"key":"2026082007100899000_2026.07.24.26358843v2.4","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00458"},{"key":"2026082007100899000_2026.07.24.26358843v2.5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172821"},{"key":"2026082007100899000_2026.07.24.26358843v2.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2635-8"},{"key":"2026082007100899000_2026.07.24.26358843v2.7","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303418"},{"key":"2026082007100899000_2026.07.24.26358843v2.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008554"},{"key":"2026082007100899000_2026.07.24.26358843v2.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.12.026"},{"key":"2026082007100899000_2026.07.24.26358843v2.10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz317"},{"key":"2026082007100899000_2026.07.24.26358843v2.11","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.2465"},{"key":"2026082007100899000_2026.07.24.26358843v2.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.131334"},{"key":"2026082007100899000_2026.07.24.26358843v2.13","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-23-162"},{"key":"2026082007100899000_2026.07.24.26358843v2.14","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202261"},{"key":"2026082007100899000_2026.07.24.26358843v2.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocmr.2024.101005"},{"key":"2026082007100899000_2026.07.24.26358843v2.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10561-y"},{"key":"2026082007100899000_2026.07.24.26358843v2.17","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00564-3"},{"key":"2026082007100899000_2026.07.24.26358843v2.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2026.03.052"},{"key":"2026082007100899000_2026.07.24.26358843v2.19","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa356.325"},{"key":"2026082007100899000_2026.07.24.26358843v2.20","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"2026082007100899000_2026.07.24.26358843v2.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1009-y"},{"key":"2026082007100899000_2026.07.24.26358843v2.22","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0471-x"},{"key":"2026082007100899000_2026.07.24.26358843v2.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.017"},{"key":"2026082007100899000_2026.07.24.26358843v2.24","doi-asserted-by":"publisher","DOI":"10.1161\/circgen.123.004200"},{"key":"2026082007100899000_2026.07.24.26358843v2.25","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-36"},{"key":"2026082007100899000_2026.07.24.26358843v2.26","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-026-03687-9"},{"key":"2026082007100899000_2026.07.24.26358843v2.27","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-314155"},{"key":"2026082007100899000_2026.07.24.26358843v2.28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.004712"},{"key":"2026082007100899000_2026.07.24.26358843v2.29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15432-4"},{"key":"2026082007100899000_2026.07.24.26358843v2.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-01049-x"},{"key":"2026082007100899000_2026.07.24.26358843v2.31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.121.003517"},{"key":"2026082007100899000_2026.07.24.26358843v2.32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40566-6"},{"key":"2026082007100899000_2026.07.24.26358843v2.33","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-024-10520-y"},{"key":"2026082007100899000_2026.07.24.26358843v2.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.076"},{"key":"2026082007100899000_2026.07.24.26358843v2.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocmr.2024.101120"},{"key":"2026082007100899000_2026.07.24.26358843v2.36","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i7.577"},{"key":"2026082007100899000_2026.07.24.26358843v2.37","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.845973"},{"key":"2026082007100899000_2026.07.24.26358843v2.38","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010134"},{"key":"2026082007100899000_2026.07.24.26358843v2.39","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m131"},{"key":"2026082007100899000_2026.07.24.26358843v2.40","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2011.2146190"},{"key":"2026082007100899000_2026.07.24.26358843v2.41","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0413-z"},{"key":"2026082007100899000_2026.07.24.26358843v2.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04103-z"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.24.26358843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:10:19Z","timestamp":1787235019000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.07.24.26358843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":42,"URL":"https:\/\/doi.org\/10.64898\/2026.07.24.26358843","relation":{},"subject":[],"published":{"date-parts":[[2026,7,27]]},"subtype":"preprint"}}