{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:14:11Z","timestamp":1785521651397,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,28]]},"group-title":"Neuroscience","reference-count":84,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Trans-thalamic circuits link cortical regions through higher-order sensory (HOs) thalamic nuclei to support cognition. These circuits are rich with metabotropic glutamate receptors (mGluRs), whose seconds-long dynamics conflict with the thalamus\u2019s traditional relay role, leaving their function unknown. Here, we present a model of group I mGluR-mediated suppression of K\n                  <jats:sup>+<\/jats:sup>\n                  leak currents in single neurons. Including mGluRs in a trans-thalamic network of spiking neurons revealed distinct modulatory roles for thalamocortical and corticothalamic mGluRs. In pyramidal neurons, thalamocortical mGluRs strengthen somato-dendritic coupling and dendritic plateau potentials, boosting feedforward propagation of sensory information to enhance decision-making in a detection task. In HOs thalamic neurons, corticothalamic mGluRs temporally integrate inputs to shift thalamic firing from burst to tonic, a prediction supported by pulvinar recordings in behaving animals. This effect increases detection of a novel stimulus (\u201cwake-up call\u201d) while attenuating detection of repeated stimuli. Therefore, mGluRs enable the HOs thalamus to dynamically modulate cortical communication.\n                <\/jats:p>","DOI":"10.64898\/2026.07.25.740691","type":"posted-content","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:45:30Z","timestamp":1785249930000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3768-9840","authenticated-orcid":false,"given":"Alan","family":"Lai","sequence":"first","affiliation":[{"name":"Center for Neural Science, New York University, New York, 10003, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3124-8474","authenticated-orcid":false,"given":"Xiao-Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, 10003, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026073110050930000_2026.07.25.740691v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.07.003"},{"key":"2026073110050930000_2026.07.25.740691v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4269"},{"key":"2026073110050930000_2026.07.25.740691v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.023"},{"key":"2026073110050930000_2026.07.25.740691v1.4","doi-asserted-by":"crossref","unstructured":"Javadzadeh, M. & Hofer, S. 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