{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:44:18Z","timestamp":1785836658276,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,31]]},"group-title":"Endocrinology (including Diabetes Mellitus and Metabolic Disease)","reference-count":70,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["UL1 TR002535"],"award-info":[{"award-number":["UL1 TR002535"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["UL1RR025780"],"award-info":[{"award-number":["UL1RR025780"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["UM1 TR004399"],"award-info":[{"award-number":["UM1 TR004399"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"University of Colorado Anschutz Health and Wellness Center","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"award":["N\/A (Canada Research Chairs program)"],"award-info":[{"award-number":["N\/A (Canada Research Chairs program)"]}],"id":[{"id":"https:\/\/ror.org\/010q4q527","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>\n                    Yoga may support changes in dietary intake and\/or physical activity levels, supporting sustainable weight loss. However, previous research has focused on yoga postures (\n                    <jats:italic>asanas<\/jats:italic>\n                    ) rather than breathing practices (\n                    <jats:italic>pranayama<\/jats:italic>\n                    ). This study used the proof-of-concept stage in the ORBIT model to evaluate feasibility, acceptability, and preliminary efficacy of a breath-based yoga program integrated within a behavioral weight loss (BWL) intervention.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fifteen participants with overweight or obesity (BMI: 31.3\u00b14.3 kg\/m\u00b2, 80% female) were enrolled in a 16-week, single-arm, group-based BWL intervention which included four breath-based yoga sessions\/week, individualized daily goals for energy intake reduction, and progressive aerobic exercise recommendations. Primary outcomes included prespecified benchmarks enrollment, retention, adherence, and acceptability. Secondary outcomes included changes in body weight and composition, metabolic health indices (e.g., blood pressure, fasting glucose, abdominal obesity), physical activity, appetite, and dietary intake.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean percent weight loss was 6.5 \u00b1 6.0%, exceeding the pre-defined proof-of-concept benchmark. Recruitment and adherence exceeded established benchmarks, with mean in-class attendance of 84.1\u00b114.6% and adherence to the prescribed duration of at-home yoga sessions averaging 85.5\u00b138.4%. However, retention was lower than the pre-specified benchmark (73% vs 80%). Positive changes were observed in waist circumference, blood pressure, and appetite traits. Self-reported satisfaction with the program and outcomes were acceptable (mean ratings &gt;6\/10).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A BWL with a breath-based, low-intensity yoga can lead to acceptable weight loss with potential benefits in key behavioral and metabolic health indices. Recruitment, high adherence, and satisfaction demonstrated feasibility.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.27.26358493","type":"posted-content","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:35:11Z","timestamp":1785512111000},"source":"Crossref","is-referenced-by-count":0,"title":["Complementing Behavioral Weight Loss with Breath-based Yoga: A Proof-of-Concept and Initial Feasibility Study"],"prefix":"10.64898","author":[{"given":"Sarah A.","family":"Purcell","sequence":"first","affiliation":[{"name":"Department of Medicine, Southern Medical Program, Centre for Chronic Disease Prevention and Management, University of British Columbia, Kelowna, British Columbia, Canada"},{"name":"School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, BC, V1V 1V7 Canada"},{"name":"School of Medicine, Division of Endocrinology Metabolism and Diabetes, University of Colorado - Anschutz Medical Campus, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dallaghan","sequence":"additional","affiliation":[{"name":"Anschutz Health and Wellness Center, University of Colorado - Anschutz Medical Campus, Aurora, CO, 80045, USA"},{"name":"Kaivalyadhama Yoga Institute, Lonalvala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Catenacci","sequence":"additional","affiliation":[{"name":"School of Medicine, Division of Endocrinology Metabolism and Diabetes, University of Colorado - Anschutz Medical Campus, Aurora, CO, 80045, USA"},{"name":"Anschutz Health and Wellness Center, University of Colorado - Anschutz Medical Campus, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Bing","sequence":"additional","affiliation":[{"name":"Anschutz Health and Wellness Center, University of Colorado - Anschutz Medical Campus, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Falkenhain","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"School of Medicine, Division of Endocrinology Metabolism and Diabetes, University of Colorado - Anschutz Medical Campus, Aurora, CO, 80045, USA"},{"name":"Anschutz Health and Wellness Center, University of Colorado - Anschutz Medical Campus, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026080401500614000_2026.07.27.26358493v1.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3060"},{"key":"2026080401500614000_2026.07.27.26358493v1.2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2021.20410"},{"key":"2026080401500614000_2026.07.27.26358493v1.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437739.71477.ee"},{"key":"2026080401500614000_2026.07.27.26358493v1.4","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.5.579"},{"key":"2026080401500614000_2026.07.27.26358493v1.5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221067"},{"key":"2026080401500614000_2026.07.27.26358493v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.03.013"},{"key":"2026080401500614000_2026.07.27.26358493v1.7","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314562741"},{"key":"2026080401500614000_2026.07.27.26358493v1.8","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.552"},{"key":"2026080401500614000_2026.07.27.26358493v1.9","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00770"},{"key":"2026080401500614000_2026.07.27.26358493v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2016.06.005"},{"key":"2026080401500614000_2026.07.27.26358493v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.07.013"},{"key":"2026080401500614000_2026.07.27.26358493v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.08.017"},{"key":"2026080401500614000_2026.07.27.26358493v1.13","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6979370"},{"key":"2026080401500614000_2026.07.27.26358493v1.14","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23089"},{"key":"2026080401500614000_2026.07.27.26358493v1.15","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000665"},{"key":"2026080401500614000_2026.07.27.26358493v1.16","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000161"},{"key":"2026080401500614000_2026.07.27.26358493v1.17","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06523-2"},{"key":"2026080401500614000_2026.07.27.26358493v1.18","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20737"},{"key":"2026080401500614000_2026.07.27.26358493v1.19","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.5.1.28"},{"key":"2026080401500614000_2026.07.27.26358493v1.20","unstructured":"Human Energy Requirements: Report of a Joint FAO\/WHO\/UNU Expert Consultation. Food and Agriculture Organization, FAO Food and Nutrition Technical Report Series No. 1; 2004."},{"key":"2026080401500614000_2026.07.27.26358493v1.21","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.4.623"},{"key":"2026080401500614000_2026.07.27.26358493v1.22","unstructured":"American College of Sports Medicine, Riebe D , Ehrman JK , Liguori G , Magal M . ACSM\u2019s Guidelines for Exercise Testing and Prescription. Tenth edition. Wolters Kluwer; 2018."},{"key":"2026080401500614000_2026.07.27.26358493v1.23","unstructured":"Services USD of H and H. Physical Activity Guidelines for Americans. 2nd ed. 2018;(APril 6, 2020)."},{"key":"2026080401500614000_2026.07.27.26358493v1.24","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-01631"},{"key":"2026080401500614000_2026.07.27.26358493v1.25","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21358"},{"key":"2026080401500614000_2026.07.27.26358493v1.26","doi-asserted-by":"crossref","unstructured":"Burrows TL , Ho YY , Rollo ME , Collins CE . Validity of Dietary Assessment Methods When Compared to the Method of Doubly Labeled Water: A Systematic Review in Adults. Vol 10.; 2019. https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2019.00850","DOI":"10.3389\/fendo.2019.00850"},{"key":"2026080401500614000_2026.07.27.26358493v1.27","first-page":"1","article-title":"Obesity: Preventing and Managing the Global Epidemic","volume":"894","year":"2000","journal-title":"Report of a WHO Consultation"},{"key":"2026080401500614000_2026.07.27.26358493v1.28","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.2.152"},{"key":"2026080401500614000_2026.07.27.26358493v1.29","first-page":"213","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism. 1949","volume":"6","year":"1990","journal-title":"Nutrition"},{"key":"2026080401500614000_2026.07.27.26358493v1.30","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21538"},{"key":"2026080401500614000_2026.07.27.26358493v1.31","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22138"},{"key":"2026080401500614000_2026.07.27.26358493v1.32","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21408"},{"key":"2026080401500614000_2026.07.27.26358493v1.33","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2002387"},{"key":"2026080401500614000_2026.07.27.26358493v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(85)90010-8"},{"key":"2026080401500614000_2026.07.27.26358493v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2009.05.016"},{"key":"2026080401500614000_2026.07.27.26358493v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.17"},{"key":"2026080401500614000_2026.07.27.26358493v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2007.01.022"},{"key":"2026080401500614000_2026.07.27.26358493v1.38","first-page":"151","article-title":"Adherence to a behavioral weight loss treatment program enhances weight loss and improvements in biomarkers","volume":"3","year":"2009","journal-title":"Patient Prefer Adherence"},{"key":"2026080401500614000_2026.07.27.26358493v1.39","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0783-5"},{"key":"2026080401500614000_2026.07.27.26358493v1.40","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-008-9161-8"},{"key":"2026080401500614000_2026.07.27.26358493v1.41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803799"},{"key":"2026080401500614000_2026.07.27.26358493v1.42","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S103649"},{"key":"2026080401500614000_2026.07.27.26358493v1.43","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0016"},{"key":"2026080401500614000_2026.07.27.26358493v1.44","doi-asserted-by":"publisher","DOI":"10.1093\/tbm\/iby114"},{"key":"2026080401500614000_2026.07.27.26358493v1.45","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2015-0493"},{"issue":"3","key":"2026080401500614000_2026.07.27.26358493v1.46","first-page":"32","article-title":"Narrative review of yoga intervention clinical trials including weight-related outcomes","volume":"19","year":"2013","journal-title":"Altern Ther Health Med"},{"key":"2026080401500614000_2026.07.27.26358493v1.47","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000922"},{"key":"2026080401500614000_2026.07.27.26358493v1.48","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000355949.56770.cf"},{"key":"2026080401500614000_2026.07.27.26358493v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803483"},{"key":"2026080401500614000_2026.07.27.26358493v1.50","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12143"},{"key":"2026080401500614000_2026.07.27.26358493v1.51","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12548"},{"key":"2026080401500614000_2026.07.27.26358493v1.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2016.02.001"},{"key":"2026080401500614000_2026.07.27.26358493v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.04.008"},{"key":"2026080401500614000_2026.07.27.26358493v1.54","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-1066-8"},{"key":"2026080401500614000_2026.07.27.26358493v1.55","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.14.1685"},{"key":"2026080401500614000_2026.07.27.26358493v1.56","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2014.981778"},{"key":"2026080401500614000_2026.07.27.26358493v1.57","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0234"},{"key":"2026080401500614000_2026.07.27.26358493v1.58","doi-asserted-by":"publisher","DOI":"10.1093\/postmj\/qgad008"},{"key":"2026080401500614000_2026.07.27.26358493v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"2026080401500614000_2026.07.27.26358493v1.60","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-018-0674-4"},{"key":"2026080401500614000_2026.07.27.26358493v1.61","doi-asserted-by":"publisher","DOI":"10.1007\/s10484-017-9351-7"},{"key":"2026080401500614000_2026.07.27.26358493v1.62","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.678"},{"key":"2026080401500614000_2026.07.27.26358493v1.63","doi-asserted-by":"publisher","DOI":"10.1093\/abm\/kaab019"},{"key":"2026080401500614000_2026.07.27.26358493v1.64","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-022-00806-8"},{"key":"2026080401500614000_2026.07.27.26358493v1.65","doi-asserted-by":"publisher","DOI":"10.3390\/nu15153452"},{"key":"2026080401500614000_2026.07.27.26358493v1.66","doi-asserted-by":"crossref","unstructured":"Purcell SA , Legget KT , Halliday TM , et al. Appetitive and Metabolic Responses to an Exercise versus Dietary Intervention in Adults with Obesity. Translational Journal of the American College of Sports Medicine. 2022;7(4). https:\/\/journals.lww.com\/acsm-tj\/fulltext\/2022\/10140\/appetitive_and_metabolic_responses_to_an_exercise.10.aspx","DOI":"10.1249\/TJX.0000000000000211"},{"key":"2026080401500614000_2026.07.27.26358493v1.67","doi-asserted-by":"publisher","DOI":"10.3390\/nu15224809"},{"key":"2026080401500614000_2026.07.27.26358493v1.68","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.373"},{"key":"2026080401500614000_2026.07.27.26358493v1.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2013.05.005"},{"key":"2026080401500614000_2026.07.27.26358493v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.191"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.27.26358493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:50:18Z","timestamp":1785833418000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.07.27.26358493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":70,"URL":"https:\/\/doi.org\/10.64898\/2026.07.27.26358493","relation":{},"subject":[],"published":{"date-parts":[[2026,7,31]]},"subtype":"preprint"}}