{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:44:42Z","timestamp":1785746682929,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,30]]},"group-title":"Neurology","reference-count":38,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["JP24dk0207068"],"award-info":[{"award-number":["JP24dk0207068"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["JP25dk0207075"],"award-info":[{"award-number":["JP25dk0207075"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP24K10653"],"award-info":[{"award-number":["JP24K10653"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP25K19014"],"award-info":[{"award-number":["JP25K19014"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Participant- and study partner-reported Cognitive Function Index scores may provide complementary information, but it remains unclear whether Alzheimer\u2019s disease biomarkers are associated with CFI scores across reporters, reporter-specific imbalance, or both.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using A4\/LEARN screening data (screening sample, N = 1,686; primary dyadic analytic sample, N = 1,682; CDR global score = 0), we jointly modeled participant-reported (CFI-PT) and study partner-reported (CFI-SP) scores in long format to evaluate biomarker associations with CFI scores and biomarker \u00d7 reporter interactions. As a secondary analysis, we compared tau PET with plasma p-tau217.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In an A4\/LEARN-adapted regional extent model, reporter balance varied across amyloid regional extent categories, with the largest participant-leading contrast observed in the exploratory restricted early cortical subgroup. Tau PET was associated with higher CFI scores, but this association did not differ detectably between reporters. Plasma p-tau217 showed no clear CFI association or reporter-specific interaction in the A4-derived, amyloid-enriched subset.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Amyloid regional extent and tau PET were associated with different features of dyadic CFI data: reporter balance and CFI burden across reporters, respectively. Joint interpretation of CFI-PT and CFI-SP may support biomarker-informed interpretation of the instrument, although the cross-sectional findings require replication and longitudinal validation.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.27.26359000","type":"posted-content","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:50:15Z","timestamp":1785437415000},"source":"Crossref","is-referenced-by-count":0,"title":["Biomarker-Informed Interpretation of Dyadic Cognitive Function Index Scores in Cognitively Unimpaired Older Adults"],"prefix":"10.64898","author":[{"given":"Ambre","family":"Mouni\u00e9","sequence":"first","affiliation":[{"name":"Dementia Inclusion and Therapeutics, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"Cognitive Sciences, Universit\u00e9 C\u00f4te d\u2019Azur, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Dementia Inclusion and Therapeutics, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Dementia Inclusion and Therapeutics, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Dementia Inclusion and Therapeutics, The University of Tokyo Hospital, Tokyo, Japan"},{"name":"Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, 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