{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:01:32Z","timestamp":1785492092657,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,31]]},"group-title":"Neuroscience","reference-count":0,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MM was supported by the Jacobs Foundation Research Fellowship through SLV. DYE was supported by the Max Planck Society through SLV. BS was supported by the German Federal Ministry of Education and Research (BMBF) and the Max Planck Society through SLV. MDH was supported by the German Research Foundation (DFG; Walter Benjamin Fellowship GZ: HE 10277\/1-1). JDK was supported by a Natural Sciences and Engineering Research Council of Canada - Postdoctoral Fellowship (NSERC-PDF). FH was supported by the European Union's Horizon 2020 Research Infrastructures Grant EBRAIN-Health 101058516 through SBE. BCB was supported by the Canadian Institutes of Health Research (CIHR), National Science and Engineering Research Council of Canada (NSERC), BrainCanada, Healthy Brains and Healthy Lives, the Canada Research Chairs (CRC) program, and the Centre for Excellence in Epilepsy at the Montreal Neurological Institute.  SBE was supported by the European Union's Horizon 2020 research and innovation programme (grant agreements 945539 [HBP SGA3], 826421 [VBC], and 101058516), the DFG (SFB 1451 and IRTG 2150), and the National Institute of Health (NIH; R01 MH074457). SLV was supported by the Max Planck Society through the Lise Meitner Excellence Program, the Jacobs Foundation Research Fellowship, the Hector Research Career Development Award, and the European Research Council (ERC) Starting Grant."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,30]]},"abstract":"<jats:p>\n                  Youth adversity has been associated with alterations in hippocampal structure; however, it remains unclear whether different forms of adversity relate distinctly to its organization across the anterior-posterior and proximal-distal axes. Here, we investigated the associations of different types of adversity with multiple structural properties of the hippocampus in 5,263 early adolescents from the ABCD Study. Hippocampal macrostructure was characterized using volume, thickness, and gyrification, whereas T1w\/T2w ratio served as an\n                  <jats:italic>in vivo<\/jats:italic>\n                  proxy for microstructure. Adversity was assessed at the family level using questionnaires on family environment and parenting, and at the socioeconomic level using income-to-needs ratio and neighborhood disadvantage measured by the Area Deprivation Index. Associations were examined for each adversity type separately in multivariate analyses and for cumulative adversity exposure in univariate models. Hippocampal features were obtained using HippUnfold, an advanced automatic segmentation approach that accounts for interindividual folding variability, and were analyzed globally as well as across the hippocampal anterior-posterior and proximal-distal axes. Socioeconomic measures showed widespread associations with hippocampal macrostructure across the whole hippocampus and both anatomical axes, whereas associations with T1w\/T2w ratio were limited and observed only for neighborhood disadvantage along the anterior-posterior axis. Cumulative adversity exposure was consistently associated with alterations in CA1 and subiculum across volume, thickness, and gyrification, but not T1w\/T2w ratio. Together, these findings suggest that different types of adversity exhibit distinct spatial associations across complementary hippocampal macro- and microstructural features, highlighting regional variation in the susceptibility of the developing hippocampus to environmental adversity.\n                <\/jats:p>","DOI":"10.64898\/2026.07.30.741706","type":"posted-content","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:55:11Z","timestamp":1785491711000},"source":"Crossref","is-referenced-by-count":0,"title":["Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence"],"prefix":"10.64898","author":[{"given":"Mylla","family":"Marsiglia","sequence":"first","affiliation":[{"name":"Research Centre Juelich, Max Planck Institute for Human Cognitive and Brain Sciences, International Max Planck Research School on Cognitive Neuroimaging, Leipzig University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doruk Yigit","family":"Eriguec","sequence":"additional","affiliation":[{"name":"Research Centre Juelich, Max Planck Institute for Human Cognitive and Brain Sciences, International Max Planck Research School on Cognitive Neuroimaging, Leipzig University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Serio","sequence":"additional","affiliation":[{"name":"Research Centre Juelich, Max Planck Institute for Human Cognitive and Brain Sciences, Max Planck School of Cognition, Heinrich Heine University Duesseldorf;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike D","family":"Hettwer","sequence":"additional","affiliation":[{"name":"University of Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4093-0582","authenticated-orcid":false,"given":"Jordan","family":"DeKraker","sequence":"additional","affiliation":[{"name":"McGill University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Waite","sequence":"additional","affiliation":[{"name":"Research Centre Juelich;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-3110","authenticated-orcid":false,"given":"Felix","family":"Hoffstaedter","sequence":"additional","affiliation":[{"name":"Research Centre Juelich, Heinrich Heine University Duesseldorf;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-6041","authenticated-orcid":false,"given":"Boris","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"McGill University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon B","family":"Eickhoff","sequence":"additional","affiliation":[{"name":"Research Centre Juelich, Max Planck School of Cognition, Heinrich Heine University Duesseldorf;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie L","family":"Valk","sequence":"additional","affiliation":[{"name":"Research Centre Juelich, Max Planck Institute for Human Cognitive and Brain Sciences, International Max Planck Research School on Cognitive Neuroimaging, Max Planck School of Cognition, Heinrich Heine University Duesseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.30.741706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:55:11Z","timestamp":1785491711000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.07.30.741706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":0,"URL":"https:\/\/doi.org\/10.64898\/2026.07.30.741706","relation":{},"subject":[],"published":{"date-parts":[[2026,7,31]]},"subtype":"preprint"}}