{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:45:27Z","timestamp":1785897927378,"version":"3.56.0"},"posted":{"date-parts":[[2026,8,3]]},"group-title":"Cell Biology","reference-count":90,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIDDK\/NIH","award":["DK074797"],"award-info":[{"award-number":["DK074797"]}]},{"name":"NIDDK\/NIH","award":["DK125740"],"award-info":[{"award-number":["DK125740"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Metabolic homeostasis depends on adaptive control of intracellular metabolite flux, yet how such control is reconfigured when canonical transport pathways fail is unknown. Here we define a conserved vesicular circuit that preserves systemic heme balance by rerouting intracellular heme flux. We show that loss of the intestinal heme exporter MRP-5 in\n                  <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                  causes lethal heme sequestration within endolysosomal compartments. This defect is bypassed by disabling the vesicular adaptor AP-3, which stabilizes and reroutes the heme importer HRG-1, restoring heme export without increasing cytosolic heme. Unbiased genetics and transcriptomics identify two previously uncharacterized SLC49A family members, HRG-13 and HRG-14, as heme exporters with distinct affinities that engage in a vesicular importer-exporter handoff. Live imaging reveals heme-enhanced contacts between HRG-1 and SLC49A-containing vesicles, consistent with direct vesicular transfer. This circuitry extends to vertebrates as disruption of the SLC49A3 homolog impairs erythropoiesis in zebrafish and causes intracellular heme overload, premature hemoglobinization and apoptosis in differentiating human erythroid cells. Together, these findings establish SLC49A3 proteins as conserved heme exporters and uncover a general principle of metabolic adaptation in which reprogramming intracellular compartmentalization, rather than increasing nutrient supply, restores systemic homeostasis.\n                <\/jats:p>","DOI":"10.64898\/2026.07.31.742071","type":"posted-content","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:20:30Z","timestamp":1785763230000},"source":"Crossref","is-referenced-by-count":0,"title":["A conserved vesicular circuit enables metabolic adaptation and maintains systemic heme homeostasis"],"prefix":"10.64898","author":[{"given":"Sohini","family":"Dutt","sequence":"first","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA"},{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Beardsley","sequence":"additional","affiliation":[{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Belot","sequence":"additional","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Carrington","sequence":"additional","affiliation":[{"name":"Zebrafish Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Bishop","sequence":"additional","affiliation":[{"name":"Zebrafish Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeepan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA"},{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA"},{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Martin","family":"Harder","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutwick Surya","family":"Ulhas","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa Dilip","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Sood","sequence":"additional","affiliation":[{"name":"Zebrafish Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Smith","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krause","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Wohlschlegel","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute A","family":"Hellmich","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany"},{"name":"Cluster of Excellence, Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyong","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Liu","sequence":"additional","affiliation":[{"name":"Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0045-0610","authenticated-orcid":false,"given":"Iqbal","family":"Hamza","sequence":"additional","affiliation":[{"name":"Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA"},{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026080418551394000_2026.07.31.742071v1.1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1197226"},{"key":"2026080418551394000_2026.07.31.742071v1.2","doi-asserted-by":"crossref","first-page":"25660","DOI":"10.1016\/S0021-9258(18)47300-0","article-title":"The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake","volume":"269","year":"1994","journal-title":"J Biol Chem"},{"key":"2026080418551394000_2026.07.31.742071v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90345-X"},{"key":"2026080418551394000_2026.07.31.742071v1.4","doi-asserted-by":"crossref","first-page":"20774","DOI":"10.1016\/S0021-9258(19)36753-5","article-title":"Regulation of iron uptake in Saccharomyces cerevisiae. The ferrireductase and Fe(II) transporter are regulated independently","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"2026080418551394000_2026.07.31.742071v1.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5468.1062"},{"key":"2026080418551394000_2026.07.31.742071v1.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2454"},{"key":"2026080418551394000_2026.07.31.742071v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118882"},{"key":"2026080418551394000_2026.07.31.742071v1.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.5105"},{"key":"2026080418551394000_2026.07.31.742071v1.9","doi-asserted-by":"publisher","DOI":"10.1021\/cr900031u"},{"key":"2026080418551394000_2026.07.31.742071v1.10","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071149"},{"key":"2026080418551394000_2026.07.31.742071v1.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500877102"},{"key":"2026080418551394000_2026.07.31.742071v1.12","doi-asserted-by":"publisher","DOI":"10.1021\/cr9001116"},{"key":"2026080418551394000_2026.07.31.742071v1.13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-062320-112625"},{"key":"2026080418551394000_2026.07.31.742071v1.14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00061"},{"key":"2026080418551394000_2026.07.31.742071v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/nature06934"},{"key":"2026080418551394000_2026.07.31.742071v1.16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.326785"},{"key":"2026080418551394000_2026.07.31.742071v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.030"},{"key":"2026080418551394000_2026.07.31.742071v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.100"},{"key":"2026080418551394000_2026.07.31.742071v1.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609865113"},{"key":"2026080418551394000_2026.07.31.742071v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.025"},{"key":"2026080418551394000_2026.07.31.742071v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00235-0"},{"key":"2026080418551394000_2026.07.31.742071v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.04.014"},{"key":"2026080418551394000_2026.07.31.742071v1.23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.760876"},{"key":"2026080418551394000_2026.07.31.742071v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01431-8"},{"key":"2026080418551394000_2026.07.31.742071v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(74)90174-9"},{"key":"2026080418551394000_2026.07.31.742071v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.04.002"},{"key":"2026080418551394000_2026.07.31.742071v1.27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001044"},{"key":"2026080418551394000_2026.07.31.742071v1.28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62422"},{"key":"2026080418551394000_2026.07.31.742071v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.08.014"},{"key":"2026080418551394000_2026.07.31.742071v1.30","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151133"},{"key":"2026080418551394000_2026.07.31.742071v1.31","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00690-10"},{"key":"2026080418551394000_2026.07.31.742071v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18607-1"},{"key":"2026080418551394000_2026.07.31.742071v1.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.04.003"},{"key":"2026080418551394000_2026.07.31.742071v1.34","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-023-00923-y"},{"key":"2026080418551394000_2026.07.31.742071v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07374-4"},{"key":"2026080418551394000_2026.07.31.742071v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.02.014"},{"key":"2026080418551394000_2026.07.31.742071v1.37","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07326-y"},{"key":"2026080418551394000_2026.07.31.742071v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.07.013"},{"key":"2026080418551394000_2026.07.31.742071v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1627"},{"key":"2026080418551394000_2026.07.31.742071v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"2026080418551394000_2026.07.31.742071v1.41","first-page":"237","article-title":"Differential expression of the globin genes in human leukemia K562(S) cells induced to differentiate by hemin or butyric acid","volume":"41","year":"1981","journal-title":"Cancer Res"},{"key":"2026080418551394000_2026.07.31.742071v1.42","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1999.0241"},{"key":"2026080418551394000_2026.07.31.742071v1.43","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-012-9574-0"},{"key":"2026080418551394000_2026.07.31.742071v1.44","doi-asserted-by":"publisher","DOI":"10.1101\/gr.276953.122"},{"key":"2026080418551394000_2026.07.31.742071v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.10.016"},{"key":"2026080418551394000_2026.07.31.742071v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00676-x"},{"key":"2026080418551394000_2026.07.31.742071v1.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.010"},{"key":"2026080418551394000_2026.07.31.742071v1.48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.592618"},{"key":"2026080418551394000_2026.07.31.742071v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109848"},{"key":"2026080418551394000_2026.07.31.742071v1.50","doi-asserted-by":"publisher","DOI":"10.1002\/0471140856.tx0109s31"},{"key":"2026080418551394000_2026.07.31.742071v1.51","unstructured":"Epstein, H.F. , and Shakes, D.C. , eds. (1995). Caenorhabditis elegans: Modern Biological Analysis of an Organism (Academic Press)."},{"key":"2026080418551394000_2026.07.31.742071v1.52","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.119.301965"},{"key":"2026080418551394000_2026.07.31.742071v1.53","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2641"},{"key":"2026080418551394000_2026.07.31.742071v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2020.10.008"},{"key":"2026080418551394000_2026.07.31.742071v1.55","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.114.169730"},{"key":"2026080418551394000_2026.07.31.742071v1.56","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.178335"},{"key":"2026080418551394000_2026.07.31.742071v1.57","doi-asserted-by":"publisher","DOI":"10.1038\/nrg794"},{"key":"2026080418551394000_2026.07.31.742071v1.58","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.144204"},{"key":"2026080418551394000_2026.07.31.742071v1.59","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3539"},{"key":"2026080418551394000_2026.07.31.742071v1.60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2111617119"},{"key":"2026080418551394000_2026.07.31.742071v1.61","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-1229-9"},{"key":"2026080418551394000_2026.07.31.742071v1.62","doi-asserted-by":"publisher","DOI":"10.17912\/W25Q2N"},{"key":"2026080418551394000_2026.07.31.742071v1.63","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.TIR118.001270"},{"key":"2026080418551394000_2026.07.31.742071v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0082-x"},{"key":"2026080418551394000_2026.07.31.742071v1.65","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0638-x"},{"key":"2026080418551394000_2026.07.31.742071v1.66","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00294"},{"key":"2026080418551394000_2026.07.31.742071v1.67","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg015"},{"key":"2026080418551394000_2026.07.31.742071v1.68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.197178"},{"key":"2026080418551394000_2026.07.31.742071v1.69","unstructured":"Westerfield, M. (2000). The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish ( Danio Rerio ), 4th Edition (Univ. of Oregon Press.)."},{"key":"2026080418551394000_2026.07.31.742071v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/ni1007"},{"key":"2026080418551394000_2026.07.31.742071v1.71","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky354"},{"key":"2026080418551394000_2026.07.31.742071v1.72","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv802"},{"key":"2026080418551394000_2026.07.31.742071v1.73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10713"},{"key":"2026080418551394000_2026.07.31.742071v1.74","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.143"},{"key":"2026080418551394000_2026.07.31.742071v1.75","doi-asserted-by":"crossref","first-page":"12198","DOI":"10.1016\/S0021-9258(17)39008-7","article-title":"Heme binding to murine erythroleukemia cells. Evidence for a heme receptor","volume":"260","year":"1985","journal-title":"J Biol Chem"},{"key":"2026080418551394000_2026.07.31.742071v1.76","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"2026080418551394000_2026.07.31.742071v1.77","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34284-8"},{"key":"2026080418551394000_2026.07.31.742071v1.78","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr703"},{"key":"2026080418551394000_2026.07.31.742071v1.79","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21287"},{"key":"2026080418551394000_2026.07.31.742071v1.80","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20945"},{"key":"2026080418551394000_2026.07.31.742071v1.81","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00935"},{"key":"2026080418551394000_2026.07.31.742071v1.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2024.102813"},{"key":"2026080418551394000_2026.07.31.742071v1.83","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.2c01246"},{"key":"2026080418551394000_2026.07.31.742071v1.84","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202400013"},{"key":"2026080418551394000_2026.07.31.742071v1.85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000880"},{"key":"2026080418551394000_2026.07.31.742071v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.04.013"},{"key":"2026080418551394000_2026.07.31.742071v1.87","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01066"},{"key":"2026080418551394000_2026.07.31.742071v1.88","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00770"},{"key":"2026080418551394000_2026.07.31.742071v1.89","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23702"},{"key":"2026080418551394000_2026.07.31.742071v1.90","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae973"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.31.742071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:55:34Z","timestamp":1785894934000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.07.31.742071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":90,"URL":"https:\/\/doi.org\/10.64898\/2026.07.31.742071","relation":{},"subject":[],"published":{"date-parts":[[2026,8,3]]},"subtype":"preprint"}}