{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:32:00Z","timestamp":1786408320036,"version":"build-2736575974"},"posted":{"date-parts":[[2026,8,3]]},"group-title":"Cancer Biology","reference-count":98,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"Intramural Research Program of the National Institutes of Health"},{"award":["R35-ES028374"],"award-info":[{"award-number":["R35-ES028374"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"The Charles and Marjorie Holloway Foundation"},{"name":"The L. 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KMEA identified patient tumor-specific upregulation of mTOR or casein kinase 2 (CK2) activity that would be undiscoverable by standard personalized genomic and transcriptomic approaches. Striking concordance was observed between KMEA predictions for specific tumors, and their sensitivity to inhibitors of mTOR or CK2 using patient tumor-derived organoids. These findings reveal potential clinically-actionable protein kinases hyperactivated in GEP-NETs, and more broadly indicate a general method for personalized cancer treatment using phosphoproteomics and KMEA-derived kinase activity signatures.<\/jats:p>","DOI":"10.64898\/2026.07.31.742097","type":"posted-content","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:20:28Z","timestamp":1785763228000},"source":"Crossref","is-referenced-by-count":0,"title":["Tumor-specific Kinase Motif Enrichment Analysis Identifies Personalized Therapeutic Cancer Targets"],"prefix":"10.64898","author":[{"given":"Tracey","family":"Pu","sequence":"first","affiliation":[{"name":"Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-9450","authenticated-orcid":false,"given":"Brian 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