{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:45:22Z","timestamp":1786189522185,"version":"build-2736575974"},"posted":{"date-parts":[[2026,8,6]]},"group-title":"Respiratory Medicine","reference-count":48,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100015391","name":"The Myositis Association","doi-asserted-by":"crossref","award":["Mentored Research Fellowship"],"award-info":[{"award-number":["Mentored Research Fellowship"]}],"id":[{"id":"10.13039\/100015391","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["Bench-to-Bedside and Back Program"],"award-info":[{"award-number":["Bench-to-Bedside and Back Program"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Intramural Research Program of the National Institutes of Health - NIEHS"},{"name":"Intramural Research Program of the National Institutes of Health - NIDCR"},{"name":"Peter and Carmen Lucia Buck Fund for Myositis Research"},{"name":"Zhang Discovery Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Rationale<\/jats:title>\n                  <jats:p>Idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) is a major cause of morbidity and mortality. We tested whether quantitative myositis-specific autoantibodies and proteomic profiling capture biological heterogeneity and prognosis beyond categorical serology.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Myositis-specific autoantibodies were quantified using the luciferase immunoprecipitation systems assay, and 184 serum proteins were measured in 226 IIM patients; 199 with higher-ILD-risk autoantibodies (Jo-1\/MDA5\/PL-7\/PL-12\/EJ), 27 with lower- ILD-risk autoantibodies (Mi-2\/NXP2\/TIF1\u03b3) and 35 healthy controls. We identified shared and subgroup-specific differences by comparing each subgroup with controls, then correlated quantitative autoantibody and protein levels within higher-risk subgroups. Additional analyses included pathway enrichment, unsupervised clustering, longitudinal lung-function change, and mortality.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher-ILD-risk subgroups shared interferon-responsive CXCR3 chemokine, IL- 6\/JAK\/STAT3, and apoptosis signaling. Dominant autoantibody subgroup profiles differed: interferon\/CXCR3 chemokine signaling with T-cell activation and monocyte recruitment in anti- Jo-1; proteostasis\/antigen-processing and vascular\/cellular stress signals in anti-MDA5; IL- 6\/macrophage and profibrotic signals in anti-PL-12; and apoptotic and innate immune activation with metabolic\/redox-stress signals in anti-PL-7. Within higher-ILD-risk subgroups, autoantibody levels correlated with interferon-response, profibrotic, and metabolic\/vascular proteins (r=0.40- 0.74; nominal p&lt;0.05). Unsupervised clustering identified four proteomic endotypes beyond autoantibody type, including an injury-stress endotype associated with worse lung function and poorer survival, and a chemokine\/checkpoint-high endotype with relatively preserved lung function. Across 203 participants with 38 deaths, a weighted 10-protein score was associated with all-cause mortality (HR, 3.28; 95% CI, 2.12-5.08; p&lt;0.001).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Integrated quantitative autoantibodies and proteomic profiling revealed shared inflammatory biology, autoantibody-associated signatures, and an injury-stress endotype associated with poor survival in IIM-ILD, supporting risk stratification beyond categorical serology.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.08.04.26359441","type":"posted-content","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:05:13Z","timestamp":1786046713000},"source":"Crossref","is-referenced-by-count":0,"title":["Proteomic Signatures and an Injury-Stress Endotype in Myositis-Associated Interstitial Lung Disease"],"prefix":"10.64898","author":[{"given":"Julio A.","family":"Huapaya","sequence":"first","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Burbelo","sequence":"additional","affiliation":[{"name":"Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[{"name":"Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijinqiu","family":"Gao","sequence":"additional","affiliation":[{"name":"Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay","family":"Turan","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salina","family":"Gairhe","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Sciome, LLC, Research Triangle Park, NC, United States."},{"name":"Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Redekar","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases (NIAID) Collaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Li","sequence":"additional","affiliation":[{"name":"Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Pastor","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha A.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam Noroozi","family":"Farhadi","sequence":"additional","affiliation":[{"name":"Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kakali","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Casal-Dominguez","sequence":"additional","affiliation":[{"name":"Muscle Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-9218","authenticated-orcid":false,"given":"Iago","family":"Pinal-Fernandez","sequence":"additional","affiliation":[{"name":"Muscle Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Christopher-Stine","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Johns Hopkins University School of Medicine. Director, Johns Hopkins Myositis Center. Baltimore, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Schiffenbauer","sequence":"additional","affiliation":[{"name":"Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.","family":"Rider","sequence":"additional","affiliation":[{"name":"Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Mammen","sequence":"additional","affiliation":[{"name":"Muscle Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-8977","authenticated-orcid":false,"given":"Sonye K.","family":"Danoff","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine Department, Johns Hopkins University School of Medicine. Director, Johns Hopkins Interstitial Lung Disease Program. Baltimore, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-0902","authenticated-orcid":false,"given":"Anthony F.","family":"Suffredini","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026080804400459000_2026.08.04.26359441v1.1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121043"},{"key":"2026080804400459000_2026.08.04.26359441v1.2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.1.9207505"},{"key":"2026080804400459000_2026.08.04.26359441v1.3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.069237"},{"key":"2026080804400459000_2026.08.04.26359441v1.4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40674-021-00177-y","article-title":"Treatment in Antisynthetase Syndrome- Associated Interstitial Lung Disease","volume":"7","year":"2021","journal-title":"Current Treatment Options in Rheumatology"},{"key":"2026080804400459000_2026.08.04.26359441v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex021"},{"key":"2026080804400459000_2026.08.04.26359441v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.01.031"},{"key":"2026080804400459000_2026.08.04.26359441v1.7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000488358","article-title":"Predictive Factors for the Long-Term Deterioration of Pulmonary Function in Interstitial Lung Disease Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies","volume":"96","year":"2018","journal-title":"Respiration"},{"key":"2026080804400459000_2026.08.04.26359441v1.8","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10067-022-06424-4","article-title":"An observational study of clinical recurrence in patients with interstitial lung disease related to the antisynthetase syndrome","volume":"42","year":"2023","journal-title":"Clin Rheumatol"},{"key":"2026080804400459000_2026.08.04.26359441v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.63"},{"key":"2026080804400459000_2026.08.04.26359441v1.10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S2213-2600(24)00267-4","article-title":"Idiopathic inflammatory myopathies related lung disease in adults","volume":"13","year":"2025","journal-title":"Lancet Respir Med"},{"key":"2026080804400459000_2026.08.04.26359441v1.11","doi-asserted-by":"crossref","unstructured":"Huapaya JA , Danoff SK . Myositis-Associated Interstitial Lung Disease. In: Janes SM , editor. Encyclopedia of Respiratory Medicine (Second Edition). Oxford: Academic Press; 2022. p. 326\u2013340.","DOI":"10.1016\/B978-0-08-102723-3.00069-X"},{"key":"2026080804400459000_2026.08.04.26359441v1.12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008443"},{"key":"2026080804400459000_2026.08.04.26359441v1.13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaf1625"},{"key":"2026080804400459000_2026.08.04.26359441v1.14","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-223873"},{"key":"2026080804400459000_2026.08.04.26359441v1.15","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1136\/ard-2024-225773","article-title":"Pathological autoantibody internalisation in myositis.","volume":"83","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"2026080804400459000_2026.08.04.26359441v1.16","doi-asserted-by":"crossref","unstructured":"Takeshita M , Suzuki K , Nakazawa M , Kamata H , Ishii M , Oyamada Y , Oshima H , Usuda S , Tsunoda K , Takeuchi T . Disease-specific autoantibody production in the lungs and salivary glands of anti-synthetase syndrome. Front Immunol 2024; 15: 1265792.","DOI":"10.3389\/fimmu.2024.1265792"},{"key":"2026080804400459000_2026.08.04.26359441v1.17","doi-asserted-by":"publisher","DOI":"10.64898\/62026.64802.64814.26346329"},{"key":"2026080804400459000_2026.08.04.26359441v1.18","doi-asserted-by":"crossref","unstructured":"Tansley SL , Snowball J , Pauling JD , Lissina A , Kuwana M , Rider LG , Ronnelid J , McHugh NJ , International Myositis A , Clinical Studies Group Myositis Autoantibody Scientific Interest G. The promise, perceptions, and pitfalls of immunoassays for autoantibody testing in myositis. Arthritis Res Ther 2020; 22: 117.","DOI":"10.1186\/s13075-020-02210-2"},{"key":"2026080804400459000_2026.08.04.26359441v1.19","first-page":"277","article-title":"Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank","volume":"42","year":"2024","journal-title":"Clin Exp Rheumatol"},{"key":"2026080804400459000_2026.08.04.26359441v1.20","doi-asserted-by":"crossref","unstructured":"Burbelo PD , Huapaya JA , Khavandgar Z , Beach M , Pinal-Fernandez I , Mammen AL , Chiorini JA , Noroozi Farhadi P , Miller FW , Schiffenbauer A , Sarkar K , Warner BM , Rider LG . Quantification of autoantibodies using a luminescent profiling method in autoimmune interstitial lung disease. Front Immunol 2024; 15: 1462242.","DOI":"10.3389\/fimmu.2024.1462242"},{"key":"2026080804400459000_2026.08.04.26359441v1.21","doi-asserted-by":"publisher","DOI":"10.1002\/art.70103"},{"key":"2026080804400459000_2026.08.04.26359441v1.22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S2213-2600(21)00503-8","article-title":"Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis","volume":"10","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026080804400459000_2026.08.04.26359441v1.23","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2021-217822"},{"key":"2026080804400459000_2026.08.04.26359441v1.24","doi-asserted-by":"crossref","unstructured":"Li Y , Wang B , Yang W , Ma F , Zou J , Li K , Tan S , Feng J , Wang Y , Qin Z , Chen Z , Ding C . Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer. Nature Communications 2024; 15: 980.","DOI":"10.1038\/s41467-024-44911-1"},{"key":"2026080804400459000_2026.08.04.26359441v1.25","doi-asserted-by":"publisher","DOI":"10.1164\/RCCM.202301-0117OC"},{"key":"2026080804400459000_2026.08.04.26359441v1.26","doi-asserted-by":"crossref","unstructured":"Wu Y , Li Y , Luo Y , Zhou Y , Liang X , Cheng L , Wu T , Wen J , Tan C , Liu Y . Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease. Front Immunol 2023; 14: 1146904.","DOI":"10.3389\/fimmu.2023.1146904"},{"key":"2026080804400459000_2026.08.04.26359441v1.27","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1002\/art.42615","article-title":"Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis","volume":"75","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"2026080804400459000_2026.08.04.26359441v1.28","doi-asserted-by":"crossref","unstructured":"Huapaya JA , Gairhe S , Kanth S , Tian X , Demirkale CY , Regenold D , Sun J , Lynch NF , Luo R , Forsberg A , Dewar R , Rehman T , Li W , Krack J , Kuruppu J , Aboye EA , Barnett C , Strich JR , Davey R , Childs R , Chertow D , Kovacs JA , Torabi- Parizi P , Suffredini AF . Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection. Frontiers in Immunology 2024; Volume 15 - 2024.","DOI":"10.3389\/fimmu.2024.1448780"},{"key":"2026080804400459000_2026.08.04.26359441v1.29","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1164\/rccm.202309-1692OC","article-title":"Machine Learning of Plasma Proteomics Classifies Diagnosis of Interstitial Lung Disease","volume":"210","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026080804400459000_2026.08.04.26359441v1.30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1164\/rccm.202402-0339OC","article-title":"Molecular Endotypes of Idiopathic Pulmonary Fibrosis: A Latent Class Analysis of Two Multicenter Observational Cohorts","volume":"210","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026080804400459000_2026.08.04.26359441v1.31","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1164\/rccm.202407-1506OC","article-title":"Proteomic Biomarkers of Survival in Non-Idiopathic Pulmonary Fibrosis Interstitial Lung Disease","volume":"211","year":"2025","journal-title":"Am J Respir Crit Care Med"},{"key":"2026080804400459000_2026.08.04.26359441v1.32","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/ajrccm\/aamag006","article-title":"Molecular endotypes predict differential response to immunosuppressant therapy in non-idiopathic pulmonary fibrosis interstitial lung disease","volume":"212","year":"2026","journal-title":"Am J Respir Crit Care Med"},{"key":"2026080804400459000_2026.08.04.26359441v1.33","doi-asserted-by":"crossref","unstructured":"Qiu Y , Feng X , Liu C , Shi Y , Xu L , You H , Wang L , Lv C , Wang F , Tan W . Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis. Arthritis Res Ther 2024; 26: 9.","DOI":"10.1186\/s13075-023-03243-z"},{"key":"2026080804400459000_2026.08.04.26359441v1.34","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s10067-023-06624-6","article-title":"Plasma proteomic profiling reveals KRT19 could be a potential biomarker in patients with anti-MDA5+ dermatomyositis","volume":"42","year":"2023","journal-title":"Clin Rheumatol"},{"key":"2026080804400459000_2026.08.04.26359441v1.35","doi-asserted-by":"crossref","unstructured":"Sparling AC , Ward JM , Sarkar K , Schiffenbauer A , Farhadi PN , Smith MA , Rahman S , Zerrouki K , Miller FW , Li JL , Casey KA , Rider LG . Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis. Arthritis Res Ther 2024; 26: 196.","DOI":"10.1186\/s13075-024-03421-7"},{"key":"2026080804400459000_2026.08.04.26359441v1.36","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.ard.2025.07.020","article-title":"Discovery of tissue-specific proteomic signatures in juvenile dermatomyositis highlights pathways reflecting persistent disease activity, clinical heterogeneity, and myositis-specific autoantibody subtype","volume":"84","author":"Group CTMfJMW","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"2026080804400459000_2026.08.04.26359441v1.37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s41927-020-00150-7","article-title":"Serum protein biomarkers for juvenile dermatomyositis: a pilot study","volume":"4","year":"2020","journal-title":"BMC Rheumatol"},{"key":"2026080804400459000_2026.08.04.26359441v1.38","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1093\/rheumatology\/kead165","article-title":"In-depth proteomic analysis of juvenile dermatomyositis serum reveals protein expression associated with muscle-specific autoantibodies","volume":"62","year":"2023","journal-title":"Rheumatology (Oxford"},{"issue":"76","key":"2026080804400459000_2026.08.04.26359441v1.39","first-page":"1955","article-title":"European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups","volume":"2017","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"2026080804400459000_2026.08.04.26359441v1.40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","year":"2015","journal-title":"Cell Syst"},{"key":"2026080804400459000_2026.08.04.26359441v1.41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"2026080804400459000_2026.08.04.26359441v1.42","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.rmed.2019.05.012","article-title":"Long-term treatment with human immunoglobulin for antisynthetase syndrome-associated interstitial lung disease","volume":"154","year":"2019","journal-title":"Respir Med"},{"key":"2026080804400459000_2026.08.04.26359441v1.43","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"2026080804400459000_2026.08.04.26359441v1.44","doi-asserted-by":"crossref","first-page":"e70161","DOI":"10.1002\/acr2.70161","article-title":"Distinct Interferon and Intracellular Signaling Signatures in Systemic Lupus Erythematosus and Dermatomyositis by Integrative Transcriptomic and Proteomic Analysis","volume":"8","year":"2026","journal-title":"ACR Open Rheumatol"},{"key":"2026080804400459000_2026.08.04.26359441v1.45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ard.2025.08.011","article-title":"Multiomics analysis uncovers subtype-specific mechanisms and biomarkers in idiopathic inflammatory myopathies","volume":"85","year":"2026","journal-title":"Ann Rheum Dis"},{"key":"2026080804400459000_2026.08.04.26359441v1.46","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1093\/rheumatology\/keaf346","article-title":"Distinct cytokine and cytokine receptor expression patterns characterize different forms of myositis","volume":"64","year":"2025","journal-title":"Rheumatology"},{"key":"2026080804400459000_2026.08.04.26359441v1.47","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008128"},{"key":"2026080804400459000_2026.08.04.26359441v1.48","doi-asserted-by":"crossref","unstructured":"Xu X , Qiu T , Sun K , Han X , Huang J , Wang X , Ge J , Yang J . Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype. Arthritis Res Ther 2025; 27: 26.","DOI":"10.1186\/s13075-025-03494-y"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.08.04.26359441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:40:18Z","timestamp":1786189218000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.08.04.26359441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":48,"URL":"https:\/\/doi.org\/10.64898\/2026.08.04.26359441","relation":{},"subject":[],"published":{"date-parts":[[2026,8,6]]},"subtype":"preprint"}}