{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:44:40Z","timestamp":1786157080386,"version":"build-2736575974"},"posted":{"date-parts":[[2026,8,5]]},"group-title":"Microbiology","reference-count":85,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["UH2AI186375"],"award-info":[{"award-number":["UH2AI186375"]}],"id":[{"id":"https:\/\/ror.org\/00k86s890","id-type":"ROR","asserted-by":"publisher"}]},{"award":["F30AI174686"],"award-info":[{"award-number":["F30AI174686"]}],"id":[{"id":"https:\/\/ror.org\/00k86s890","id-type":"ROR","asserted-by":"publisher"}]},{"award":["GM139776-03"],"award-info":[{"award-number":["GM139776-03"]}],"id":[{"id":"https:\/\/ror.org\/00k86s890","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AI0077485"],"award-info":[{"award-number":["AI0077485"]}],"id":[{"id":"https:\/\/ror.org\/00k86s890","id-type":"ROR","asserted-by":"publisher"}]},{"award":["GMR35154959"],"award-info":[{"award-number":["GMR35154959"]}],"id":[{"id":"https:\/\/ror.org\/00k86s890","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AI001254"],"award-info":[{"award-number":["AI001254"]}],"id":[{"id":"https:\/\/ror.org\/00k86s890","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Ebola virus (EBOV) disease (EVD) is a hemorrhagic disease caused by EBOV infection. EVD outcomes in pregnant women are similar to non-pregnant women however, EVD is associated with negative fetal outcomes in \u223c99% of cases. There is a critical need for a tractable small animal model to study maternal\/fetal transmission of EBOV. We utilized interferon \u03b1\/\u03b2 receptor knock out mice infected and authentic EBOV or the model virus, recombinant vesicular stomatitis virus encoding EBOV glycoprotein (rVSV\/EBOV). Infection with either virus during late pregnancy resulted in placental infection and vertical transmission to the fetus within 2-3 days. Robust levels of maternal and fetal proinflammatory cytokines were evident by day 5 after EBOV infection. Within the placenta, trophoblasts and endothelial cells were viral antigen positive. Elimination of the endosomal receptor NPC1 in junctional zone trophoblasts reduced placental infection and virus transmission to the fetus. These studies establish an infectious model that provides EBOV trafficking and pathogenesis insights during pregnancy.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>This model provides key insights into how viral trafficking and maternal immune responses drive adverse fetal outcomes during gestational Ebola virus infection.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.08.04.742335","type":"posted-content","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:46:24Z","timestamp":1785991584000},"source":"Crossref","is-referenced-by-count":0,"title":["Developing and Characterizing a Murine Model of\n                  <i>In Utero<\/i>\n                  Transmission of Ebola Virus"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-1912","authenticated-orcid":false,"given":"Hanora Van","family":"Ert","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA"},{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey W.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige T.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Kardin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Eubank","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7475-3011","authenticated-orcid":false,"given":"Maryam","family":"Fakhimi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Liebermann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-0722","authenticated-orcid":false,"given":"Kelly N.","family":"Messingham","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA USA"},{"name":"Department of Dermatology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-8017","authenticated-orcid":false,"given":"Mark K.","family":"Santillan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-4424","authenticated-orcid":false,"given":"Mark L.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-9587","authenticated-orcid":false,"given":"Andrea","family":"Marzi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-4484","authenticated-orcid":false,"given":"Wendy","family":"Maury","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA"},{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026080719201745000_2026.08.04.742335v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0147-3"},{"key":"2026080719201745000_2026.08.04.742335v1.2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","year":"2011","journal-title":"The Lancet"},{"key":"2026080719201745000_2026.08.04.742335v1.3","first-page":"39","volume-title":"Methods in Molecular Biology","volume":"1628","year":"2017"},{"key":"2026080719201745000_2026.08.04.742335v1.4","first-page":"387","article-title":"The Pathogenesis of Ebola Virus Disease","volume":"12","year":"2016","journal-title":"Annu. Rev. Pathol. Mech. Dis. 2017"},{"key":"2026080719201745000_2026.08.04.742335v1.5","unstructured":"WHO, Ebola virus disease Fact Sheet. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ebola-virus-disease."},{"key":"2026080719201745000_2026.08.04.742335v1.6","first-page":"1","article-title":"Epidemiological profile of the Ebola virus disease outbreak in Nigeria, July-September 2014","volume":"21","year":"2015","journal-title":"Pan African Medical Journal"},{"key":"2026080719201745000_2026.08.04.742335v1.7","doi-asserted-by":"crossref","unstructured":"N. G. Onyeneho , N. I. Aronu , I. Igwe , J. Okeibunor , T. Diarra , J. N. Anoko , M. H. Djingarey , Z. Yoti , D. Chamla , A. S. Gueye , The Impact of the Ebola Virus Disease Epidemic among Women in the Provinces of North Kivu and Ituri in the Democratic Republic of the Congo. J. Immunol. Sci. Suppl 3, 11 (2023).","DOI":"10.29245\/2578-3009\/2023\/S3.1103"},{"key":"2026080719201745000_2026.08.04.742335v1.8","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1016\/S2214-109X(15)70009-4","article-title":"Ebola crisis: The unequal impact on women and children\u2019s health","volume":"3","year":"2015","journal-title":"Lancet Glob. Health"},{"key":"2026080719201745000_2026.08.04.742335v1.9","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01300-25"},{"key":"2026080719201745000_2026.08.04.742335v1.10","doi-asserted-by":"crossref","unstructured":"K. N. Messingham , P. T. Richards , A. Fleck , R. A. Patel , M. Djurkovic , J. Elliff , S. Connell , T. P. Crowe , J. Munoz Gonzalez , F. Gourronc , J. A. Dillard , R. A. Davey , A. Klingelhutz , O. Shtanko , W. Maury , Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin. Sci. Adv. 11 (2025).","DOI":"10.1126\/sciadv.adr6140"},{"key":"2026080719201745000_2026.08.04.742335v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/nature10380"},{"key":"2026080719201745000_2026.08.04.742335v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.53"},{"key":"2026080719201745000_2026.08.04.742335v1.13","doi-asserted-by":"publisher","DOI":"10.1086\/514305"},{"key":"2026080719201745000_2026.08.04.742335v1.14","doi-asserted-by":"publisher","DOI":"10.1086\/515386"},{"key":"2026080719201745000_2026.08.04.742335v1.15","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0502"},{"key":"2026080719201745000_2026.08.04.742335v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63591-2"},{"key":"2026080719201745000_2026.08.04.742335v1.17","doi-asserted-by":"publisher","DOI":"10.1086\/379199"},{"key":"2026080719201745000_2026.08.04.742335v1.18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03316-12"},{"key":"2026080719201745000_2026.08.04.742335v1.19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02163-14"},{"key":"2026080719201745000_2026.08.04.742335v1.20","doi-asserted-by":"publisher","DOI":"10.3390\/v4091477"},{"key":"2026080719201745000_2026.08.04.742335v1.21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1473-3099(20)30194-8","article-title":"Review Pregnancy and breastfeeding in the context of Ebola : a systematic review","volume":"20","year":"2020","journal-title":"Lancet Infect. Dis"},{"key":"2026080719201745000_2026.08.04.742335v1.22","doi-asserted-by":"crossref","unstructured":"N. D. Kayem , C. Benson , C. Y. L. Aye , S. Barker , M. Tome , S. Kennedy , P. Ariana , P. Horby , Ebola virus disease in pregnancy: a systematic review and meta-analysis. Trans. R. Soc. Trop. Med. Hyg., 509\u2013522 (2021).","DOI":"10.1093\/trstmh\/trab180"},{"key":"2026080719201745000_2026.08.04.742335v1.23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejogrb.2020.12.037","article-title":"Ebola infection in pregnancy, an ongoing challenge for both the global health expert and the pregnant woman\u2014A review","volume":"258","year":"2021","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"key":"2026080719201745000_2026.08.04.742335v1.24","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180130121946"},{"key":"2026080719201745000_2026.08.04.742335v1.25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/bdra.23558","article-title":"Ebola virus disease and pregnancy: A review of the current knowledge of Ebola virus pathogenesis, maternal, and neonatal outcomes","volume":"109","year":"2017","journal-title":"Birth Defects Res"},{"key":"2026080719201745000_2026.08.04.742335v1.26","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw206"},{"key":"2026080719201745000_2026.08.04.742335v1.27","doi-asserted-by":"crossref","unstructured":"S. A. Riesle-Sbarbaro , G. Wibbelt , A. D\u00fcx , V. Kouakou , M. Bokelmann , K. Hansen-Kant , N. Kirchoff , M. Laue , N. Kromarek , A. Lander , U. Vogel , A. Wahlbrink , D. M. Wozniak , D. P. Scott , J. B. Prescott , L. Schaade , E. Couacy-Hymann , A. Kurth , Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats. Nat. Commun. 15 (2024).","DOI":"10.1038\/s41467-024-45231-0"},{"key":"2026080719201745000_2026.08.04.742335v1.28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110656"},{"key":"2026080719201745000_2026.08.04.742335v1.29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004691"},{"key":"2026080719201745000_2026.08.04.742335v1.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006983"},{"key":"2026080719201745000_2026.08.04.742335v1.31","doi-asserted-by":"crossref","first-page":"e0007819","DOI":"10.1371\/journal.pntd.0007819","article-title":"IL-4\/IL-13 polarization of macrophages enhances Ebola virus glycoprotein-dependent infection","volume":"13","year":"2019","journal-title":"PLoS Negl. Trop. Dis"},{"key":"2026080719201745000_2026.08.04.742335v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.104"},{"key":"2026080719201745000_2026.08.04.742335v1.33","doi-asserted-by":"crossref","unstructured":"P. T. Richards , J. A. A. Brise\u00f1o , B. A. Brunton , W. Maury , \u201cIn Vivo Investigation of Filovirus Glycoprotein-Mediated Infection in a BSL2 Setting\u201d (2025; https:\/\/link.springer.com\/10.1007\/978-1-0716-4256-6_13), pp. 183\u2013198.","DOI":"10.1007\/978-1-0716-4256-6_13"},{"key":"2026080719201745000_2026.08.04.742335v1.34","doi-asserted-by":"publisher","DOI":"10.1177\/01926233211042270"},{"key":"2026080719201745000_2026.08.04.742335v1.35","doi-asserted-by":"crossref","first-page":"105500","DOI":"10.1016\/j.antiviral.2022.105500","article-title":"Mouse models of Zika virus transplacental transmission","volume":"210","year":"2023","journal-title":"Antiviral Res"},{"key":"2026080719201745000_2026.08.04.742335v1.36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173013"},{"key":"2026080719201745000_2026.08.04.742335v1.37","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw248"},{"key":"2026080719201745000_2026.08.04.742335v1.38","doi-asserted-by":"crossref","unstructured":"M. Hemberger , C. W. Hanna , W. Dean , Mechanisms of early placental development in mouse and humans. Nat. Rev. Genet. 21 (2020).","DOI":"10.1038\/s41576-019-0169-4"},{"key":"2026080719201745000_2026.08.04.742335v1.39","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg043"},{"key":"2026080719201745000_2026.08.04.742335v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.01.009"},{"key":"2026080719201745000_2026.08.04.742335v1.41","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0007"},{"key":"2026080719201745000_2026.08.04.742335v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.06.005"},{"key":"2026080719201745000_2026.08.04.742335v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2022.11.003"},{"key":"2026080719201745000_2026.08.04.742335v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63592-4"},{"key":"2026080719201745000_2026.08.04.742335v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.08.009"},{"key":"2026080719201745000_2026.08.04.742335v1.46","doi-asserted-by":"crossref","first-page":"13260","DOI":"10.1038\/s41598-021-92751-6","article-title":"A mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease","volume":"11","year":"2021","journal-title":"Sci. Rep"},{"key":"2026080719201745000_2026.08.04.742335v1.47","doi-asserted-by":"publisher","DOI":"10.3390\/v14112445"},{"key":"2026080719201745000_2026.08.04.742335v1.48","first-page":"1","article-title":"Chemokines as potential biomarkers for predicting the course of COVID-19 \u2013 a review of the literature","volume":"16","year":"2025","journal-title":"Front. Immunol"},{"key":"2026080719201745000_2026.08.04.742335v1.49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042052"},{"key":"2026080719201745000_2026.08.04.742335v1.50","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba9001"},{"key":"2026080719201745000_2026.08.04.742335v1.51","doi-asserted-by":"crossref","unstructured":"L. J. Yockey , K. A. Jurado , N. Arora , A. Millet , T. Rakib , K. M. Milano , A. K. Hastings , E. Fikrig , Y. Kong , T. L. Horvath , S. Weatherbee , H. J. Kliman , C. B. Coyne , A. Iwasaki , Type I interferons instigate fetal demise after Zika virus infection. Sci. Immunol. 3 (2018).","DOI":"10.1126\/sciimmunol.aao1680"},{"key":"2026080719201745000_2026.08.04.742335v1.52","doi-asserted-by":"crossref","unstructured":"R. L. Casazza , D. T. Philip , H. M. Lazear , Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner. mBio 13 (2022).","DOI":"10.1128\/mbio.03857-21"},{"key":"2026080719201745000_2026.08.04.742335v1.53","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev-virology-111821-101531","article-title":"Antiviral and Immunomodulatory Effects of Interferon Lambda at the Maternal-Fetal Interface","volume":"11","year":"2024","journal-title":"Annu. Rev. Virol"},{"key":"2026080719201745000_2026.08.04.742335v1.54","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128553"},{"key":"2026080719201745000_2026.08.04.742335v1.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.07.036"},{"key":"2026080719201745000_2026.08.04.742335v1.56","doi-asserted-by":"crossref","unstructured":"C. C. Zhou , J. Chang , T. Mi , S. Abbasi , D. Gu , L. Huang , W. Z. Zhang , R. E. Kellems , R. J. Schwartz , Y. Xia , Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice. PLoS One 7 (2012).","DOI":"10.1371\/journal.pone.0029236"},{"key":"2026080719201745000_2026.08.04.742335v1.57","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp552"},{"key":"2026080719201745000_2026.08.04.742335v1.58","first-page":"446","article-title":"The clinical spectrum of fetal Niemann-Pick type C","volume":"149","year":"2009","journal-title":"Am. J. Med. Genet. A"},{"key":"2026080719201745000_2026.08.04.742335v1.59","doi-asserted-by":"crossref","unstructured":"K. A. Pennington , J. M. Schlitt , L. C. Schulz , Isolation of primary mouse trophoblast cells and trophoblast invasion assay. Journal of Visualized Experiments, 1\u20136 (2012).","DOI":"10.3791\/3202-v"},{"key":"2026080719201745000_2026.08.04.742335v1.60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0005-2736(73)90060-6","article-title":"Filipin as a fluorescent probe for the location of cholesterol in the membranes of fragmented sarcoplasmic reticulum","volume":"291","year":"1973","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"key":"2026080719201745000_2026.08.04.742335v1.61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1388-1981(00)00055-X","article-title":"Intracellular cholesterol trafficking: role of the NPC1 protein","volume":"1486","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"2026080719201745000_2026.08.04.742335v1.62","first-page":"1","article-title":"Innate Immune Response to Viral Infections at the Maternal-Fetal Interface in Human Pregnancy","volume":"8","year":"2021","journal-title":"Front. Med. (Lausanne"},{"key":"2026080719201745000_2026.08.04.742335v1.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.02.018"},{"key":"2026080719201745000_2026.08.04.742335v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(92)90043-T"},{"key":"2026080719201745000_2026.08.04.742335v1.65","doi-asserted-by":"crossref","unstructured":"E. F. Cornish , I. Filipovic , F. \u00c5senius , D. J. Williams , T. McDonnell , Innate Immune Responses to Acute Viral Infection During Pregnancy. Front. Immunol. 11 (2020).","DOI":"10.3389\/fimmu.2020.572567"},{"key":"2026080719201745000_2026.08.04.742335v1.66","doi-asserted-by":"crossref","unstructured":"Y. Alippe , L. Wang , R. Coskun , S. P. Muraro , F. R. Zhao , M. Elam-Noll , J. M. White , D. M. Vota , V. C. Hauk , J. I. Gordon , S. A. Handley , M. S. Diamond , Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua. Journal of Experimental Medicine 221 (2024).","DOI":"10.1084\/jem.20240694"},{"key":"2026080719201745000_2026.08.04.742335v1.67","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11121400"},{"key":"2026080719201745000_2026.08.04.742335v1.68","first-page":"15","article-title":"Animal Models for Filovirus Infections","volume":"39","year":"2018","journal-title":"Zool. Res"},{"key":"2026080719201745000_2026.08.04.742335v1.69","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.073353"},{"key":"2026080719201745000_2026.08.04.742335v1.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.05.004"},{"key":"2026080719201745000_2026.08.04.742335v1.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.08.008"},{"key":"2026080719201745000_2026.08.04.742335v1.72","first-page":"1","article-title":"Type III Interferons Produced by Human Placental Trophoblasts Confer Protection Against Zika Virus Infection","volume":"19","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2026080719201745000_2026.08.04.742335v1.73","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-6-1365"},{"key":"2026080719201745000_2026.08.04.742335v1.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105496"},{"key":"2026080719201745000_2026.08.04.742335v1.75","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.036210-0"},{"key":"2026080719201745000_2026.08.04.742335v1.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.07.017"},{"key":"2026080719201745000_2026.08.04.742335v1.77","unstructured":"World Health Organization, Disease Outbreak News; Bundibugyo Virus Disease, Democratic Republic of the Congo and Uganda (2026)."},{"key":"2026080719201745000_2026.08.04.742335v1.78","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00610-y"},{"key":"2026080719201745000_2026.08.04.742335v1.79","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp552"},{"key":"2026080719201745000_2026.08.04.742335v1.80","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.150259"},{"key":"2026080719201745000_2026.08.04.742335v1.81","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-020-00230-5"},{"key":"2026080719201745000_2026.08.04.742335v1.82","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a118408"},{"key":"2026080719201745000_2026.08.04.742335v1.83","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"2026080719201745000_2026.08.04.742335v1.84","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23276-8"},{"key":"2026080719201745000_2026.08.04.742335v1.85","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-123"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.08.04.742335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:20:31Z","timestamp":1786155631000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.08.04.742335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":85,"URL":"https:\/\/doi.org\/10.64898\/2026.08.04.742335","relation":{},"subject":[],"published":{"date-parts":[[2026,8,5]]},"subtype":"preprint"}}