{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:07Z","timestamp":1792790347604,"version":"4.5.0"},"posted":{"date-parts":[[2026,8,6]]},"group-title":"Immunology","reference-count":59,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"funder":[{"award":["5F32GM146400"],"award-info":[{"award-number":["5F32GM146400"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["5R01AG016636"],"award-info":[{"award-number":["5R01AG016636"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["5R01GM044619"],"award-info":[{"award-number":["5R01GM044619"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"name":"HHMI","award":["GMAS Fund 279015"],"award-info":[{"award-number":["GMAS Fund 279015"]}],"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Detecting and responding to pathogenic bacteria is an essential function of eukaryotic cells. As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. In fact, mitochondrial morphology and function are often altered during early bacterial infection. However, the mechanism by which bacterial pathogen attack triggers mitochondrial responses is unknown. Here, we demonstrate that infection by the pathogenic bacterium\n                  <jats:italic>Staphylococcus aureus<\/jats:italic>\n                  or\n                  <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                  or hypoxia leads to remodeling of the mitochondrial network in the host\n                  <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                  . Our analysis discovers that lysosome-related organelle (LRO) genes are required for this remodeling and indicates that LROs also precipitate downstream infection-response gene expression.\n                <\/jats:p>","DOI":"10.64898\/2026.08.04.742833","type":"posted-content","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:20:18Z","timestamp":1786015218000},"source":"Crossref","is-referenced-by-count":0,"title":["Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in\n                  <i>Caenorhabditis elegans<\/i>"],"prefix":"10.64898","author":[{"given":"Jennifer D.","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA"},{"name":"Department of Biology, Queens College CUNY, Flushing, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick M.","family":"Ausubel","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Ruvkun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Department 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