{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:08:44Z","timestamp":1789232924385,"version":"build-2803163510"},"posted":{"date-parts":[[2026,8,5]]},"group-title":"Developmental Biology","reference-count":123,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["R01GM117407"],"award-info":[{"award-number":["R01GM117407"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["R01GM130764"],"award-info":[{"award-number":["R01GM130764"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["R01AG045842"],"award-info":[{"award-number":["R01AG045842"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["R35GM127049"],"award-info":[{"award-number":["R35GM127049"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["T32DK007328"],"award-info":[{"award-number":["T32DK007328"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["NSF GRFP DGE-2036197"],"award-info":[{"award-number":["NSF GRFP DGE-2036197"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Research Council CoG ChromoSOMe","award":["N\u00b0819179"],"award-info":[{"award-number":["N\u00b0819179"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Forkhead box O (FoxO) transcription factors (DAF-16 in\n                  <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                  ) regulate aging, metabolism, and development. Canonically, FoxO\/DAF-16 activity is regulated by insulin\/insulin- like receptor (DAF-2) signaling, which inhibits its nuclear localization. In\n                  <jats:italic>C. elegans<\/jats:italic>\n                  , strong loss- of-function\n                  <jats:italic>daf-16; daf-2<\/jats:italic>\n                  double mutants are embryonic lethal. However, because\n                  <jats:italic>daf-2<\/jats:italic>\n                  null mutants are maternally rescued as embryos and then arrest as larvae, the role of DAF-2 signaling in embryogenesis is unknown. We therefore used quantitative imaging and genetics to study DAF- 16 and DAF-2 in early\n                  <jats:italic>C. elegans<\/jats:italic>\n                  embryos. DAF-16 was uniformly low in all nuclei at the 2- to 4- cell stage. From the 8- to 64-cell stage, DAF-16 became enriched in 1-2 nuclei of germ lineage cells. This patterning required germ fate determinants and the lipid phosphatase PTEN\/DAF-18, but not DAF-2 kinase activity, and was independent of maternal age. We also found that\n                  <jats:italic>daf-16; daf-2<\/jats:italic>\n                  double mutant embryos failed morphogenesis, with severe mitotic defects as early as the 1-cell stage. This work identifies germ lineage-specific DAF-16 patterning and a role for DAF-16 in early embryogenesis that is independent of canonical DAF-2 signaling.\n                <\/jats:p>","DOI":"10.64898\/2026.08.04.742880","type":"posted-content","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:55:12Z","timestamp":1785941712000},"source":"Crossref","is-referenced-by-count":0,"title":["Canonical insulin-like receptor DAF-2 signaling-independent patterning and role for FoxO\/DAF- 16 in early embryos"],"prefix":"10.64898","author":[{"given":"Michael S.","family":"Mauro","sequence":"first","affiliation":[{"name":"Dept. of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032"},{"name":"Susquehanna University, Dept. of Biology, Selinsgrove, PA 17870"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Peiser","sequence":"additional","affiliation":[{"name":"Dept. of Biological Sciences, Columbia University, New York, NY 10025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia L.","family":"Martin","sequence":"additional","affiliation":[{"name":"Dept. of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Tristian","family":"Wiles","sequence":"additional","affiliation":[{"name":"Dept. of Biological Sciences, Columbia University, New York, NY 10025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dumont","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institute Jacques Monod, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Shirasu-Hiza","sequence":"additional","affiliation":[{"name":"Dept. of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-2072","authenticated-orcid":false,"given":"Julie C.","family":"Canman","sequence":"additional","affiliation":[{"name":"Dept. of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 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