{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:44:35Z","timestamp":1786628675837,"version":"build-2736575974"},"posted":{"date-parts":[[2026,8,11]]},"group-title":"Genetics","reference-count":56,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Oxygen is essential for all terrestrial animals, but there is dramatic variability in how well different animals and even different cell types can adapt to reduced oxygen availability. We used a meta-analysis of the literature, with a focus on mouse studies, to identify pathways that might act to protect animals in low oxygen environments. We identified 108 genes whose mRNA levels change under hypoxia, and 55 genes critical for mounting a response to hypoxia. With this data, we developed a list of conserved genes, and we tested three\n                  <jats:italic>C.elegans<\/jats:italic>\n                  genes previously uncharacterized in hypoxia,\n                  <jats:italic>mxl-3<\/jats:italic>\n                  ,\n                  <jats:italic>yap-1,<\/jats:italic>\n                  and\n                  <jats:italic>ador-1<\/jats:italic>\n                  , and found that loss of function altered egg-laying during and after hypoxia. Our method provides a more targeted approach of how to screen for hypoxic phenotypes and study in more genetically tractable organisms to show mechanisms.\n                <\/jats:p>","DOI":"10.64898\/2026.08.05.743086","type":"posted-content","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:35:24Z","timestamp":1786505724000},"source":"Crossref","is-referenced-by-count":0,"title":["Meta-analysis of Genes and Pathways that Protect Against Hypoxia"],"prefix":"10.64898","author":[{"given":"Emmett","family":"McGranaghan","sequence":"first","affiliation":[{"name":"Trinity College, Department of Biology, 300 Summit Street, Hartford, CT, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger Z.","family":"Watzinger","sequence":"additional","affiliation":[{"name":"Trinity College, Department of Biology, 300 Summit Street, Hartford, CT, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norton","family":"Kerri-Ann","sequence":"additional","affiliation":[{"name":"Computational Sciences Program, Reem-Kayden Center for Science and Computation, Bard College, New York. 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