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We compared disease trajectory embeddings from Delphi-2M, a transformer model trained only on the health records of 400,000 UK Biobank participants, with genome-wide genetic correlations across 19 neurological and psychiatric disorders. Clinical and genetic similarity partly converged across disorder pairs (Mantel r = 0.33). Both measures placed most disorders closer to their own diagnostic category than to the other. Both also made the same three exceptions: multiple sclerosis, migraine, and essential tremor sat closer on average to psychiatric than to neurological disorders. Clinical trajectories and genetic architecture thus draw the same diagnostic boundary and break it in the same places. These findings support a more integrated approach to neurological and psychiatric disorders.<\/jats:p>","DOI":"10.64898\/2026.08.06.26359855","type":"posted-content","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:45:14Z","timestamp":1786369514000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical trajectories and genetic architecture across the neurological\u2013psychiatric boundary"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-2872","authenticated-orcid":false,"given":"J.","family":"Kopal","sequence":"first","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-5215","authenticated-orcid":false,"given":"O.B.","family":"Smeland","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-5900","authenticated-orcid":false,"given":"A.","family":"Amanzadi","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8643-4915","authenticated-orcid":false,"given":"B.","family":"Erdos","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6286-5614","authenticated-orcid":false,"given":"J.","family":"Fuhrer","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-250X","authenticated-orcid":false,"given":"A.","family":"Shadrin","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-2625","authenticated-orcid":false,"given":"O.","family":"Frei","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-386X","authenticated-orcid":false,"given":"D.","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6865-8795","authenticated-orcid":false,"given":"K.S.","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6126-2966","authenticated-orcid":false,"given":"A.M.","family":"Dale","sequence":"additional","affiliation":[{"name":"Center for Multimodal Imaging and Genetics, J. 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