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Despite continuous exposure of hosts to the plant glycans that constitute dietary fiber, it remains unclear whether these foreign structures induce mucosal immune responses. We report that humans and mice generate antibodies specific for common glycans in plant foods. Oral exposure to individual fiber types induced T cell-independent, glycan-specific IgM and IgA. The induction of anti-fiber antibodies required colonization by particular microbes, since germ-free mice and mice harboring representatives of several bacterial phyla failed to respond. The OMM12 model community was sufficient to rescue antibody induction, and dietary fiber glycans were detected on the surfaces of OMM12 microbes, suggesting a route by which bacteria trigger anti-fiber immune responses. Our results reveal a direct impact of dietary fiber on the adaptive immune system with implications for host control of fiber breakdown by bacteria in the gut lumen.<\/jats:p>","DOI":"10.64898\/2026.08.07.743361","type":"posted-content","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:10:16Z","timestamp":1786662616000},"source":"Crossref","is-referenced-by-count":0,"title":["Gut Bacteria Prime Host Antibody Responses Against Ingested Dietary Fiber Glycans"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-5408","authenticated-orcid":false,"given":"Giovanni","family":"Vega","sequence":"first","affiliation":[{"name":"Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, 95064 USA"},{"name":"Graduate Program in Biological Sciences and Engineering, University of California, Santa Cruz, Santa Cruz, CA, 95064 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-3551","authenticated-orcid":false,"given":"Carolina","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, 94720, USA; 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