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The hexanucleotide repeat expansion GGGGCC (G\n                  <jats:sub>4<\/jats:sub>\n                  C\n                  <jats:sub>2<\/jats:sub>\n                  ) in the\n                  <jats:italic>C9ORF72<\/jats:italic>\n                  gene is the most common cause of ALS and FTD, which results in the accumulation of dipeptide-repeat protein aggregates. Regulation of protein synthesis at the level of the initiation factor eIF2\u03b1 has been suggested as a transversal event contributing to neurodegeneration in ALS and FTD. eIF2\u03b1 phosphorylation blocks protein synthesis to alleviate protein misfolding overload, but conversely it can reduce the expression of synaptic proteins resulting in neuronal dysfunction. Dibenzoylmethane (DBM) is a small molecule that reverses the translational attenuation mediated by eIF2\u03b1 phosphorylation which has been shown to alleviate neurodegeneration in prion-infected mice and Tau transgenic animals. Here we investigated the efficacy of the oral administration of DBM in protecting a mouse model of C9ORF72 pathogenesis. Treatment of mice with 0.5% of DBM mixture in powdered food\n                  <jats:italic>ad libitum<\/jats:italic>\n                  was sufficient to prevent cognitive impairment in C9ORF72 mice. Unexpectedly, DBM treatment did not modify the content of poly(GA) and poly(GR) protein inclusion in the hippocampus and brain cortex. Proteomic profiling of brain tissue indicated that DBM administration corrected nearly 70% of the changes in gene expression triggered by expanded G\n                  <jats:sub>4<\/jats:sub>\n                  C\n                  <jats:sub>2<\/jats:sub>\n                  , where the main pathways modified by DBM were related to cytoskeleton organization, ALS, and metabolic processes. Most proteins corrected by DBM in our C9ORF72 model were also altered in the brain of human FTD\/ALS patients. Overall, our results reinforce the idea that targeting protein synthesis with small molecules in patients carrying C9ORF72 mutations may result in improved cognitive capacity.\n                <\/jats:p>","DOI":"10.64898\/2026.08.07.743573","type":"posted-content","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:10:19Z","timestamp":1786367419000},"source":"Crossref","is-referenced-by-count":0,"title":["Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse model"],"prefix":"10.64898","author":[{"given":"Paulina","family":"Torres","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile"},{"name":"Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Becerra","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences 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