{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:35:31Z","timestamp":1786998931330,"version":"build-2736575974"},"posted":{"date-parts":[[2026,8,13]]},"group-title":"Immunology","reference-count":53,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"id":[{"id":"https:\/\/ror.org\/05sjnvv07","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002028","name":"Collins Medical Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002028","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"crossref","award":["1253470"],"award-info":[{"award-number":["1253470"]}],"id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012331","name":"LEO Foundation","doi-asserted-by":"crossref","award":["LF-OC-23-001147"],"award-info":[{"award-number":["LF-OC-23-001147"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["P30CA069533"],"award-info":[{"award-number":["P30CA069533"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,13]]},"abstract":"<jats:p>\n                  Tissue-resident memory B cells (B\n                  <jats:sub>RM<\/jats:sub>\n                  ) provide powerful localized protection against microbial infection in barrier tissues. It is unknown if analogous B\n                  <jats:sub>RM<\/jats:sub>\n                  populations survey solid tumors and contribute to anti-cancer immunity. We profiled B cells from patients with colorectal cancer and cutaneous basal cell carcinoma and identified a CD69\n                  <jats:sup>+<\/jats:sup>\n                  memory B cell population consistent with a tissue-resident phenotype. Integrative analysis of transcriptomic datasets identified an optimized signature enriched across cancer types. Tumor infiltrating B\n                  <jats:sub>RM<\/jats:sub>\n                  -like cells preferentially exhibited autoreactivity and their signature correlated with patient outcomes and response to immunotherapy. Skin and lung targeted vaccination established localized B\n                  <jats:sub>RM<\/jats:sub>\n                  that provided IgA dependent organ specific protection upon tumor challenge in murine models. These findings establish B\n                  <jats:sub>RM<\/jats:sub>\n                  as an active component of anti-cancer immunity via preferential reactivity to tumor associated self-antigens.\n                <\/jats:p>","DOI":"10.64898\/2026.08.08.743713","type":"posted-content","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:05:19Z","timestamp":1786644319000},"source":"Crossref","is-referenced-by-count":0,"title":["Tissue-resident memory B cells augment local anti-cancer immunity via IgA"],"prefix":"10.64898","author":[{"given":"Abrar","family":"Samiea","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA"},{"name":"Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon, USA"},{"name":"Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, 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