{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:24:06Z","timestamp":1791779046243,"version":"4.3.4"},"posted":{"date-parts":[[2026,8,17]]},"group-title":"Neurology","reference-count":22,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["DHS CTR 057001"],"award-info":[{"award-number":["DHS CTR 057001"]}],"id":[{"id":"https:\/\/ror.org\/01smpj292","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIH\/NIA","award":["P30AG072980"],"award-info":[{"award-number":["P30AG072980"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Novel capillary-blood collection methods have not yet been evaluated for a wide range of central nervous system (CNS) and neurodegenerative disease-related proteins. Biomarkers of Alzheimer\u2019s disease (AD) and related disorders (ADRD) collected from devices like the Tasso+, a minimally invasive upper-arm capillary blood collection device, must be compared to traditional venipuncture to assess for validity.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Participants underwent blood collection via traditional venipuncture and Tasso+ in a clinical research setting. The Nucleic Acid Linked Immuno-Sandwich Assay (NULISA) CNS panel was used for biomarker quantification in venous and Tasso-derived plasma.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Eighty-three participants (age mean\u00b1SD 76.8\u00b18.2 years, 79.5% cognitively unimpaired) completed blood collection. Little to no correlation was found between venous and Tasso+ plasma for p-tau217, but the correlation was improved by using a brain-derived (BD)-p-tau217\/BD-p-tau181 ratio. Extremely strong correlations were found for neurofilament light (NfL) and glial fibrillary acidic protein (GFAP). Among the 131 biomarkers measured, 51 (38.9%) had a Pearson R \u2265 0.90; 27 (20.6%) had values between 0.70-0.90; 26 (19.9%) had values between 0.30-0.70; and 27 (20.6%) had values \u22640.30.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>The Tasso+ accurately measures NfL and GFAP, but caution is warranted when measuring other AD\/ADRD biomarkers, as agreement with venous plasma appears to be protein or ratio dependent. These results highlight that important biomarker-specific differences must be considered when translating capillary blood collection approaches. They also further support foundations for development of these methods, highlighting both the opportunities and remaining challenges for translating the promise of blood-based biomarkers beyond AD\/ADRD specialty clinics and research settings.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.08.13.26360406","type":"posted-content","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:15:19Z","timestamp":1787001319000},"source":"Crossref","is-referenced-by-count":2,"title":["Performance of upper-arm capillary blood collection for Alzheimer\u2019s disease and central nervous system biomarkers: comparison of Tasso+ and venous plasma"],"prefix":"10.64898","author":[{"given":"Taraneh E.","family":"Atri","sequence":"first","affiliation":[{"name":"Banner Sun Health Research Institute, Banner Health, Sun City, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3696-3795","authenticated-orcid":false,"given":"Marisa N.","family":"Denkinger","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute, Banner Health, Sun City, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Liu","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute, Banner Health, Sun City, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-8654","authenticated-orcid":false,"given":"Alpana","family":"Singh","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute, Banner Health, Sun City, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Surdyn","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute, Banner 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Kuramoto","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute, Banner Health, Sun City, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tain\u00e1 M.","family":"Marques","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute, Banner Health, Sun City, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3848-1324","authenticated-orcid":false,"given":"Jessica B.","family":"Langbaum","sequence":"additional","affiliation":[{"name":"Banner Alzheimer\u2019s Institute, Banner Health, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-6973","authenticated-orcid":false,"given":"Alireza","family":"Atri","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute, 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