{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:09:46Z","timestamp":1788905386978,"version":"build-2803163510"},"posted":{"date-parts":[[2026,8,19]]},"group-title":"Neuroscience","reference-count":118,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011730","name":"Templeton World Charity Foundation","doi-asserted-by":"crossref","award":["TWCF-2022-30262"],"award-info":[{"award-number":["TWCF-2022-30262"]}],"id":[{"id":"10.13039\/501100011730","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03cpe7c52","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018260","name":"Tiny Blue Dot Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018260","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Psilocybin produces rapid and lasting therapeutic effects, yet how 5-HT2A receptor activation reshapes brain-wide circuit dynamics during acute drug administration remains poorly understood. Using simultaneous multi-region Neuropixels recordings of 46,360 single units from 35 mice, together with scalp electroencephalography (EEG), pupillometry, and locomotion monitoring, we provide a brain-wide, single-unit and field-potential characterization of psilocybin\u2019s acute effects, with pharmacological dissection using the 5-HT2A antagonist ketanserin. Psilocybin selectively reconfigured burst coding, rather than mean firing rate, across cortical, thalamic, and hippocampal circuits: burst firing decreased in hippocampal CA1\u2013CA3 and was bidirectionally modulated in the thalamus, with the reticular nucleus bursting more and first-order geniculate nuclei bursting less. Critically, most of these burst effects were abolished by ketanserin, consistent with at least partial 5-HT2A receptor dependence. These data suggest that the psychedelic state is not simply a matter of how much neurons fire, but of how they fire, pointing to a region-specific, 5-HT2A-associated reconfiguration of burst coding that may underlie the acute phenomenology of the psilocybin experience.<\/jats:p>","DOI":"10.64898\/2026.08.14.744865","type":"posted-content","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:10:10Z","timestamp":1787163010000},"source":"Crossref","is-referenced-by-count":1,"title":["Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-8296","authenticated-orcid":false,"given":"D.","family":"Momi","sequence":"first","affiliation":[{"name":"Noel Drury, M.D. Institute for Translational Depression Discoveries, University of California, Irvine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7312-5375","authenticated-orcid":false,"given":"Y.","family":"Nahas","sequence":"additional","affiliation":[{"name":"University of Chicago, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8096-5766","authenticated-orcid":false,"given":"D.","family":"Wyrick","sequence":"additional","affiliation":[{"name":"Allen Institute, Studio D3, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-2680","authenticated-orcid":false,"given":"L. C.","family":"Marks","sequence":"additional","affiliation":[{"name":"Allen Institute, Brain and Consciousness, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-9171","authenticated-orcid":false,"given":"L. D.","family":"Claar","sequence":"additional","affiliation":[{"name":"Allen Institute, Brain and Consciousness, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-9114","authenticated-orcid":false,"given":"R.","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Allen Institute, Brain and Consciousness, Seattle, WA, USA"},{"name":"Humboldt-Universit\u00e4t zu Berlin, Bernstein Center for Computational Neuroscience Berlin and Institute of Biology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-3886","authenticated-orcid":false,"given":"P.","family":"Seyfourian","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-1143","authenticated-orcid":false,"given":"D. A.","family":"Pizzagalli","sequence":"additional","affiliation":[{"name":"Noel Drury, M.D. Institute for Translational Depression Discoveries, University of California, Irvine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2196-1498","authenticated-orcid":false,"given":"M.","family":"Buice","sequence":"additional","affiliation":[{"name":"Allen Institute, Studio D3, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-2832","authenticated-orcid":false,"given":"T.","family":"Ott","sequence":"additional","affiliation":[{"name":"Humboldt-Universit\u00e4t zu Berlin, Bernstein Center for Computational Neuroscience Berlin and Institute of Biology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6482-8067","authenticated-orcid":false,"given":"C.","family":"Koch","sequence":"additional","affiliation":[{"name":"Allen Institute, Brain and Consciousness, Seattle, WA, USA"},{"name":"Tiny Blue Dot Foundation, Santa Monica, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7121-4442","authenticated-orcid":false,"given":"I.","family":"Rembado","sequence":"additional","affiliation":[{"name":"Allen Institute, Brain and Consciousness, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026090814500868000_2026.08.14.744865v2.1","first-page":"410","article-title":"\u2019Consciousness and anesthesia\u2019, Science, 322: 876-80. Arnsten, A. F. 2009. \u2019Stress signalling pathways that impair prefrontal cortex structure and function\u2019","volume":"10","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"2026090814500868000_2026.08.14.744865v2.2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4087"},{"key":"2026090814500868000_2026.08.14.744865v2.3","doi-asserted-by":"publisher","DOI":"10.1038\/11184"},{"key":"2026090814500868000_2026.08.14.744865v2.4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-05-02870.1994"},{"key":"2026090814500868000_2026.08.14.744865v2.5","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2013.00193"},{"key":"2026090814500868000_2026.08.14.744865v2.6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00221-022-06328-4","article-title":"Tonic serotonergic input increases the burst firing mode and diminishes the firing rate of reticular thalamic nucleus neurons through 5-HT1A receptors activation in anesthetized rats","volume":"240","year":"2022","journal-title":"Exp Brain Res"},{"key":"2026090814500868000_2026.08.14.744865v2.7","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01170.2003"},{"key":"2026090814500868000_2026.08.14.744865v2.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.046"},{"key":"2026090814500868000_2026.08.14.744865v2.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.021"},{"key":"2026090814500868000_2026.08.14.744865v2.10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s42003-025-09412-x","article-title":"Vigilance state dissociation induced by 5-MeO-DMT in mice","volume":"9","year":"2026","journal-title":"Commun Biol"},{"key":"2026090814500868000_2026.08.14.744865v2.11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-24-10966.2002"},{"key":"2026090814500868000_2026.08.14.744865v2.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4769-4"},{"key":"2026090814500868000_2026.08.14.744865v2.13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119598109"},{"key":"2026090814500868000_2026.08.14.744865v2.14","doi-asserted-by":"publisher","DOI":"10.1124\/pr.118.017160"},{"key":"2026090814500868000_2026.08.14.744865v2.15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13282-7"},{"key":"2026090814500868000_2026.08.14.744865v2.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-013-3579-0"},{"key":"2026090814500868000_2026.08.14.744865v2.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.12.035"},{"key":"2026090814500868000_2026.08.14.744865v2.18","doi-asserted-by":"crossref","unstructured":"Claar, L. D. , I. Rembado , J. R. Kuyat , S. Russo , L. C. Marks , S. R. Olsen , and C. Koch . 2023. \u2019Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice\u2019, Elife, 12.","DOI":"10.7554\/eLife.84630.3"},{"key":"2026090814500868000_2026.08.14.744865v2.19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-01-00604.1995"},{"key":"2026090814500868000_2026.08.14.744865v2.20","doi-asserted-by":"publisher","DOI":"10.1162\/NECO_a_00864"},{"key":"2026090814500868000_2026.08.14.744865v2.21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-030-11135-9_8","article-title":"Burst Detection Methods","volume":"22","year":"2019","journal-title":"Adv Neurobiol"},{"key":"2026090814500868000_2026.08.14.744865v2.22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4586"},{"key":"2026090814500868000_2026.08.14.744865v2.23","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01744-z"},{"key":"2026090814500868000_2026.08.14.744865v2.24","unstructured":"De Filippo, R. , R. Gillis , D. Wyrick , M. Carlson , S. Durand , R.C. Peene , A. Bawany , A. Amaya , H. Belski , C. Grasso , W. Han , J. Kenney , C. Kiselycznyk , H. Loeffler , L. Marks , R. Naidoo , B. Ouellette , L. Suarez , J. Swapp , T. Johnson , J. Weber , J. Wilkes , P.A. Groblewski , A. Williford , M. Buice , C. Koch , I. Rembado , J. Lecoq , and T. Ott . Under submission. \u2019Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise\u2019."},{"key":"2026090814500868000_2026.08.14.744865v2.25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.155580"},{"key":"2026090814500868000_2026.08.14.744865v2.26","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab406"},{"key":"2026090814500868000_2026.08.14.744865v2.27","doi-asserted-by":"crossref","unstructured":"Ekins, T. G. , I. Brooks , S. Kailasa , C. Rybicki-Kler , I. Jedrasiak-Cape , E. Donoho , G. A. Mashour , J. Rech , and O. J. Ahmed . 2023. \u2019Cellular rules underlying psychedelic control of prefrontal pyramidal neurons\u2019, bioRxiv.","DOI":"10.1101\/2023.10.20.563334"},{"key":"2026090814500868000_2026.08.14.744865v2.28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41398-022-02103-9","article-title":"Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice","volume":"12","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2026090814500868000_2026.08.14.744865v2.29","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq142"},{"key":"2026090814500868000_2026.08.14.744865v2.30","doi-asserted-by":"publisher","DOI":"10.1113\/JP281510"},{"key":"2026090814500868000_2026.08.14.744865v2.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119434"},{"key":"2026090814500868000_2026.08.14.744865v2.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.06.006"},{"key":"2026090814500868000_2026.08.14.744865v2.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16325-w"},{"key":"2026090814500868000_2026.08.14.744865v2.34","doi-asserted-by":"publisher","DOI":"10.1016\/0891-0618(94)00039-V"},{"key":"2026090814500868000_2026.08.14.744865v2.35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13929"},{"key":"2026090814500868000_2026.08.14.744865v2.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108922"},{"key":"2026090814500868000_2026.08.14.744865v2.37","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.4.1782"},{"key":"2026090814500868000_2026.08.14.744865v2.38","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1111\/ejn.12725","article-title":"Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants","volume":"40","year":"2014","journal-title":"Eur J Neurosci"},{"key":"2026090814500868000_2026.08.14.744865v2.39","doi-asserted-by":"publisher","DOI":"10.1038\/nature22324"},{"key":"2026090814500868000_2026.08.14.744865v2.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0020-1"},{"key":"2026090814500868000_2026.08.14.744865v2.41","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2880"},{"key":"2026090814500868000_2026.08.14.744865v2.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.07.016"},{"key":"2026090814500868000_2026.08.14.744865v2.43","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-019-1716-Z"},{"key":"2026090814500868000_2026.08.14.744865v2.44","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00447-0"},{"key":"2026090814500868000_2026.08.14.744865v2.45","doi-asserted-by":"crossref","unstructured":"Hesselgrave, N. , T. A. Troppoli , A. B. Wulff , A. B. Cole , and S. M. Thompson . 2021. \u2019Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice\u2019, Proc Natl Acad Sci U S A, 118.","DOI":"10.1073\/pnas.2022489118"},{"key":"2026090814500868000_2026.08.14.744865v2.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2026.106649"},{"key":"2026090814500868000_2026.08.14.744865v2.47","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1038\/s41467-025-60774-6","article-title":"Distinct subnetworks of the mouse anterior thalamic nuclei","volume":"16","year":"2025","journal-title":"Nat Commun"},{"key":"2026090814500868000_2026.08.14.744865v2.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.038"},{"key":"2026090814500868000_2026.08.14.744865v2.49","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2025.11.009","article-title":"Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks","volume":"189","year":"2026","journal-title":"Cell"},{"key":"2026090814500868000_2026.08.14.744865v2.50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69132-6"},{"key":"2026090814500868000_2026.08.14.744865v2.51","doi-asserted-by":"publisher","DOI":"10.1038\/nature24636"},{"key":"2026090814500868000_2026.08.14.744865v2.52","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903390402"},{"key":"2026090814500868000_2026.08.14.744865v2.53","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3262"},{"key":"2026090814500868000_2026.08.14.744865v2.54","doi-asserted-by":"crossref","unstructured":"Koch, Christof . 1999. Biophysics of computation : information processing in single neurons (Oxford University Press: New York).","DOI":"10.1093\/oso\/9780195104912.001.0001"},{"key":"2026090814500868000_2026.08.14.744865v2.55","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3007-12.2013"},{"key":"2026090814500868000_2026.08.14.744865v2.56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-38967-0"},{"key":"2026090814500868000_2026.08.14.744865v2.57","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01177-4"},{"key":"2026090814500868000_2026.08.14.744865v2.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.11.006"},{"key":"2026090814500868000_2026.08.14.744865v2.59","doi-asserted-by":"publisher","DOI":"10.1038\/18686"},{"key":"2026090814500868000_2026.08.14.744865v2.60","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25317"},{"key":"2026090814500868000_2026.08.14.744865v2.61","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10070-9"},{"key":"2026090814500868000_2026.08.14.744865v2.62","doi-asserted-by":"crossref","unstructured":"Liu, L. D. , S. Chen , H. Hou , S. J. West , M. Faulkner , Laboratory International Brain , M. N. Economo , N. Li , and K. Svoboda . 2021. \u2019Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains\u2019, eNeuro, 8.","DOI":"10.1523\/ENEURO.0241-21.2021"},{"key":"2026090814500868000_2026.08.14.744865v2.63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15222"},{"key":"2026090814500868000_2026.08.14.744865v2.64","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1998.0336"},{"key":"2026090814500868000_2026.08.14.744865v2.65","first-page":"45","article-title":"\u2019What we can do and what we cannot do with fMRI\u2019, Nature, 453: 869-78. Lopez-Gimenez, J. F., and J. Gonzalez-Maeso. 2018. \u2019Hallucinogens and Serotonin 5-HT(2A) Receptor-Mediated Signaling Pathways\u2019","volume":"36","year":"2008","journal-title":"Curr Top Behav Neurosci"},{"key":"2026090814500868000_2026.08.14.744865v2.66","doi-asserted-by":"crossref","unstructured":"Lu, O. D. , K. White , K. Raymond , C. Liu , A. S. Klein , N. Green , S. Vaillancourt , A. Gallagher , L. Shindy , A. Li , K. Wallquist , R. Li , M. Zou , A. B. Casey , L. P. Cameron , M. B. Pomrenze , V. Sohal , M. A. Kheirbek , A. M. Gomez , S. Lammel , B. D. Heifets , and R. Malenka . 2025. \u2019A multi-institutional investigation of psilocybin\u2019s effects on mouse behavior\u2019, bioRxiv.","DOI":"10.1101\/2025.04.08.647810"},{"key":"2026090814500868000_2026.08.14.744865v2.67","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.6.2185"},{"key":"2026090814500868000_2026.08.14.744865v2.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.022"},{"key":"2026090814500868000_2026.08.14.744865v2.69","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.209"},{"key":"2026090814500868000_2026.08.14.744865v2.70","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.14egn9q16l5d\/v1"},{"key":"2026090814500868000_2026.08.14.744865v2.71","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00366.2013"},{"key":"2026090814500868000_2026.08.14.744865v2.72","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0209-y"},{"key":"2026090814500868000_2026.08.14.744865v2.73","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12818"},{"key":"2026090814500868000_2026.08.14.744865v2.74","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071795"},{"key":"2026090814500868000_2026.08.14.744865v2.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.02.047"},{"key":"2026090814500868000_2026.08.14.744865v2.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.10.005"},{"key":"2026090814500868000_2026.08.14.744865v2.77","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0623-08.2008"},{"key":"2026090814500868000_2026.08.14.744865v2.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.020"},{"key":"2026090814500868000_2026.08.14.744865v2.79","doi-asserted-by":"publisher","DOI":"10.1038\/nature13186"},{"key":"2026090814500868000_2026.08.14.744865v2.80","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41398-023-02691-0","article-title":"The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics","volume":"13","year":"2023","journal-title":"Transl Psychiatry"},{"key":"2026090814500868000_2026.08.14.744865v2.81","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00987.2006"},{"key":"2026090814500868000_2026.08.14.744865v2.82","doi-asserted-by":"publisher","DOI":"10.1080\/1355621021000005937"},{"key":"2026090814500868000_2026.08.14.744865v2.83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0571p.x"},{"key":"2026090814500868000_2026.08.14.744865v2.84","doi-asserted-by":"crossref","first-page":"e2522000123","DOI":"10.1073\/pnas.2522000123","article-title":"Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice","volume":"123","year":"2026","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090814500868000_2026.08.14.744865v2.85","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)90223-2"},{"key":"2026090814500868000_2026.08.14.744865v2.86","doi-asserted-by":"crossref","unstructured":"Preller, K. H. , J. B. Burt , J. L. Ji , C. H. Schleifer , B. D. Adkinson , P. Stampfli , E. Seifritz , G. Repovs , J. H. Krystal , J. D. Murray , F. X. Vollenweider , and A. Anticevic . 2018. \u2019Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor\u2019, Elife, 7.","DOI":"10.7554\/eLife.35082"},{"key":"2026090814500868000_2026.08.14.744865v2.87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815129116"},{"key":"2026090814500868000_2026.08.14.744865v2.88","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1038\/s41380-025-03182-y","article-title":"Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin","volume":"30","year":"2025","journal-title":"Mol Psychiatry"},{"key":"2026090814500868000_2026.08.14.744865v2.89","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1854"},{"key":"2026090814500868000_2026.08.14.744865v2.90","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.14530"},{"key":"2026090814500868000_2026.08.14.744865v2.91","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09767-w"},{"key":"2026090814500868000_2026.08.14.744865v2.92","doi-asserted-by":"crossref","unstructured":"Raval, N. R. , A. Johansen , L. L. Donovan , N. F. Ros , B. Ozenne , H. D. Hansen , and G. M. Knudsen . 2021. \u2019A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT(2A) Receptor Density in the Pig Brain\u2019, Int J Mol Sci, 22.","DOI":"10.20944\/preprints202011.0742.v1"},{"key":"2026090814500868000_2026.08.14.744865v2.93","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20920"},{"key":"2026090814500868000_2026.08.14.744865v2.94","doi-asserted-by":"publisher","DOI":"10.1101\/lm.631207"},{"key":"2026090814500868000_2026.08.14.744865v2.95","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4197"},{"key":"2026090814500868000_2026.08.14.744865v2.96","doi-asserted-by":"publisher","DOI":"10.1113\/JP283539"},{"key":"2026090814500868000_2026.08.14.744865v2.97","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58717-2"},{"key":"2026090814500868000_2026.08.14.744865v2.98","doi-asserted-by":"crossref","unstructured":"Saravanan, V. , G. J. Berman , and S. J. Sober . 2020. \u2019Application of the hierarchical bootstrap to multi-level data in neuroscience\u2019, Neuron Behav Data Anal Theory, 3.","DOI":"10.1101\/819334"},{"key":"2026090814500868000_2026.08.14.744865v2.99","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3749-04.2004"},{"key":"2026090814500868000_2026.08.14.744865v2.100","doi-asserted-by":"crossref","first-page":"110848","DOI":"10.1016\/j.jneumeth.2026.110848","article-title":"Pupil-DLC: An open-source deep learning pipeline for scalable, marker-less tracking of pupil dynamics across conscious and unconscious states","volume":"435","year":"2026","journal-title":"J Neurosci Methods"},{"key":"2026090814500868000_2026.08.14.744865v2.101","doi-asserted-by":"crossref","unstructured":"Shao, L. X. , C. Liao , P. A. Davoudian , N. K. Savalia , Q. Jiang , C. Wojtasiewicz , D. Tan , J. D. Nothnagel , R. J. Liu , S. C. Woodburn , O. M. Bilash , H. Kim , A. Che , and A. C. Kwan . 2025. \u2019Psilocybin\u2019s lasting action requires pyramidal cell types and 5-HT(2A) receptors\u2019, Nature.","DOI":"10.1038\/s41586-025-08813-6"},{"key":"2026090814500868000_2026.08.14.744865v2.102","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.06.008"},{"key":"2026090814500868000_2026.08.14.744865v2.103","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.07.003"},{"key":"2026090814500868000_2026.08.14.744865v2.104","doi-asserted-by":"crossref","unstructured":"Sherman, S.M. , and R. W. Guillery . 2006. \u2019Exploring the Thalamus and Its Role in Cortical Function\u2019, MIT Press.","DOI":"10.7551\/mitpress\/2940.001.0001"},{"key":"2026090814500868000_2026.08.14.744865v2.105","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03171-x"},{"key":"2026090814500868000_2026.08.14.744865v2.106","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aa5eea"},{"key":"2026090814500868000_2026.08.14.744865v2.107","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.014"},{"key":"2026090814500868000_2026.08.14.744865v2.108","doi-asserted-by":"crossref","unstructured":"Skyberg, R. J. , C. W. Fields , D. M. Martins , and C. M. Niell . 2025. \u2019The impact of the serotonergic psychedelic DOI on active vision in freely moving mice\u2019, bioRxiv.","DOI":"10.1101\/2025.10.14.682230"},{"key":"2026090814500868000_2026.08.14.744865v2.109","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7893"},{"key":"2026090814500868000_2026.08.14.744865v2.110","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-18-07118.1998"},{"key":"2026090814500868000_2026.08.14.744865v2.111","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00181-9"},{"key":"2026090814500868000_2026.08.14.744865v2.112","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2614"},{"key":"2026090814500868000_2026.08.14.744865v2.113","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0249-x"},{"key":"2026090814500868000_2026.08.14.744865v2.114","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00646-3"},{"key":"2026090814500868000_2026.08.14.744865v2.115","doi-asserted-by":"publisher","DOI":"10.1038\/S41583-020-0367-2"},{"key":"2026090814500868000_2026.08.14.744865v2.116","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199812010-00024"},{"key":"2026090814500868000_2026.08.14.744865v2.117","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-05-02199.1993"},{"key":"2026090814500868000_2026.08.14.744865v2.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.concog.2011.01.007"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.08.14.744865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:50:17Z","timestamp":1788904217000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.08.14.744865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":118,"URL":"https:\/\/doi.org\/10.64898\/2026.08.14.744865","relation":{},"subject":[],"published":{"date-parts":[[2026,8,19]]},"subtype":"preprint"}}