{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:57:06Z","timestamp":1788404226454,"version":"build-2803163510"},"posted":{"date-parts":[[2026,8,19]]},"group-title":"Pediatrics","reference-count":63,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","award":["R01MH074090"],"award-info":[{"award-number":["R01MH074090"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["R01HD104938"],"award-info":[{"award-number":["R01HD104938"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Gastrointestinal (GI) conditions are common among children with neurodevelopmental disabilities (NDDs), and are associated with functional impairment, behavioral symptoms, and increased health care utilization. A unique relationship between autism and GI dysfunction has been proposed, leading to a focus on autism in GI research, management guidelines, and clinical tool development. Leveraging &gt;20 years of electronic health record data and a cohort of 42,204 cases with attention-deficit\/hyperactivity disorder, autism, cerebral palsy, epilepsy, or intellectual disability and 297,402 controls without NDDs, we quantified associations between NDDs and GI conditions in children. GI conditions were more common in cases than controls across all individual NDDs; intellectual disability and cerebral palsy were most strongly associated with having a GI condition. In this work, clinically recognized GI morbidity was elevated across all NDDs and not unique to autism, suggesting that a broader, transdiagnostic approach to GI dysfunction in children with NDDs is warranted.<\/jats:p>","DOI":"10.64898\/2026.08.17.26360370","type":"posted-content","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:35:19Z","timestamp":1787168119000},"source":"Crossref","is-referenced-by-count":1,"title":["Elevated Rates of Gastrointestinal Dysfunction in Children with Neurodevelopmental Disabilities: Not Just an Autism Issue"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-1962","authenticated-orcid":false,"given":"Juliann M.","family":"Savatt","sequence":"first","affiliation":[{"name":"Department of Genomic Health, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Pistner","family":"Nixon","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-5521","authenticated-orcid":false,"given":"Alexander S.F.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Johns","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-300X","authenticated-orcid":false,"given":"Lauren Kasparson","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa Lese","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-4210","authenticated-orcid":false,"given":"David H.","family":"Ledbetter","sequence":"additional","affiliation":[{"name":"Institute for Pediatric Rare Diseases, College of Medicine, Florida State University, Tallahassee, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-0635","authenticated-orcid":false,"given":"Thomas D.","family":"Challman","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-6338","authenticated-orcid":false,"given":"Scott M.","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine, Geisinger, Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026082205000647000_2026.08.17.26360370v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44472-1"},{"key":"2026082205000647000_2026.08.17.26360370v1.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-0811"},{"key":"2026082205000647000_2026.08.17.26360370v1.3","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816653782"},{"key":"2026082205000647000_2026.08.17.26360370v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2024.104135"},{"key":"2026082205000647000_2026.08.17.26360370v1.5","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2020.167"},{"key":"2026082205000647000_2026.08.17.26360370v1.6","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2671"},{"key":"2026082205000647000_2026.08.17.26360370v1.7","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14307"},{"key":"2026082205000647000_2026.08.17.26360370v1.8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0924"},{"key":"2026082205000647000_2026.08.17.26360370v1.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0921"},{"key":"2026082205000647000_2026.08.17.26360370v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00225-2"},{"key":"2026082205000647000_2026.08.17.26360370v1.11","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12873"},{"key":"2026082205000647000_2026.08.17.26360370v1.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-090857"},{"key":"2026082205000647000_2026.08.17.26360370v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-04303-x"},{"key":"2026082205000647000_2026.08.17.26360370v1.14","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1854"},{"key":"2026082205000647000_2026.08.17.26360370v1.15","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.963102"},{"key":"2026082205000647000_2026.08.17.26360370v1.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03701.x"},{"key":"2026082205000647000_2026.08.17.26360370v1.17","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.70034"},{"key":"2026082205000647000_2026.08.17.26360370v1.18","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v13.i5.143"},{"key":"2026082205000647000_2026.08.17.26360370v1.19","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.705126"},{"key":"2026082205000647000_2026.08.17.26360370v1.20","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2024.12"},{"key":"2026082205000647000_2026.08.17.26360370v1.21","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp22X720077"},{"key":"2026082205000647000_2026.08.17.26360370v1.22","doi-asserted-by":"publisher","DOI":"10.3109\/13668250.2017.1310829"},{"key":"2026082205000647000_2026.08.17.26360370v1.23","doi-asserted-by":"publisher","DOI":"10.1177\/13623613251362349"},{"key":"2026082205000647000_2026.08.17.26360370v1.24","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-024-06387-2"},{"key":"2026082205000647000_2026.08.17.26360370v1.25","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1973-x"},{"key":"2026082205000647000_2026.08.17.26360370v1.26","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-020-04786-9"},{"key":"2026082205000647000_2026.08.17.26360370v1.27","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2549"},{"key":"2026082205000647000_2026.08.17.26360370v1.28","doi-asserted-by":"publisher","DOI":"10.1177\/13623613211062667"},{"key":"2026082205000647000_2026.08.17.26360370v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpede.2023.07.003"},{"key":"2026082205000647000_2026.08.17.26360370v1.30","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3995"},{"key":"2026082205000647000_2026.08.17.26360370v1.31","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000001174"},{"key":"2026082205000647000_2026.08.17.26360370v1.32","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-023-00575-0"},{"key":"2026082205000647000_2026.08.17.26360370v1.33","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i42.6626"},{"key":"2026082205000647000_2026.08.17.26360370v1.34","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.3658"},{"key":"2026082205000647000_2026.08.17.26360370v1.35","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.3815"},{"key":"2026082205000647000_2026.08.17.26360370v1.36","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200604002-00011"},{"key":"2026082205000647000_2026.08.17.26360370v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2011.10.008"},{"key":"2026082205000647000_2026.08.17.26360370v1.38","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.3034"},{"key":"2026082205000647000_2026.08.17.26360370v1.39","doi-asserted-by":"publisher","DOI":"10.1177\/1362361309106418"},{"key":"2026082205000647000_2026.08.17.26360370v1.40","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-4300K"},{"key":"2026082205000647000_2026.08.17.26360370v1.41","doi-asserted-by":"publisher","DOI":"10.2147\/phmt.S85717"},{"key":"2026082205000647000_2026.08.17.26360370v1.42","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v11.i9.605"},{"key":"2026082205000647000_2026.08.17.26360370v1.43","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1878C"},{"key":"2026082205000647000_2026.08.17.26360370v1.44","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1878D"},{"key":"2026082205000647000_2026.08.17.26360370v1.45","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0900N"},{"key":"2026082205000647000_2026.08.17.26360370v1.46","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-018-3767-7"},{"key":"2026082205000647000_2026.08.17.26360370v1.47","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2707"},{"key":"2026082205000647000_2026.08.17.26360370v1.48","unstructured":"in Diagnostic and statistical manual of mental disorders: DSM-5\u2122, 5th ed. xliv, 947\u2013 xliv, 947 (American Psychiatric Publishing, Inc., Arlington, VA, US, 2013)."},{"key":"2026082205000647000_2026.08.17.26360370v1.49","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"2026082205000647000_2026.08.17.26360370v1.50","unstructured":"Fox, J. W. , S An R Companion to Applied Regression. Third edn, (Sage, 2019)."},{"key":"2026082205000647000_2026.08.17.26360370v1.51","unstructured":"R Core Team. (R Foundation for Statistical Computing, Vienna, Austria, 2021)."},{"key":"2026082205000647000_2026.08.17.26360370v1.52","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v042.i08"},{"key":"2026082205000647000_2026.08.17.26360370v1.53","unstructured":"Kosmidis, I. brglm: Bias Reduction in Binary-Response Generalized Linear Models, <https:\/\/cran.r-project.org\/package=brglm> (2025)."},{"key":"2026082205000647000_2026.08.17.26360370v1.54","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6973.170"},{"key":"2026082205000647000_2026.08.17.26360370v1.55","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2656"},{"key":"2026082205000647000_2026.08.17.26360370v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57342-3"},{"key":"2026082205000647000_2026.08.17.26360370v1.57","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00857-1"},{"key":"2026082205000647000_2026.08.17.26360370v1.58","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0778-5"},{"key":"2026082205000647000_2026.08.17.26360370v1.59","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01104-0"},{"key":"2026082205000647000_2026.08.17.26360370v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.04.004"},{"key":"2026082205000647000_2026.08.17.26360370v1.61","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-021-05031-7"},{"key":"2026082205000647000_2026.08.17.26360370v1.62","unstructured":"Nikolov, R. N . et al. 405\u2013413 (Springer, 2009)."},{"key":"2026082205000647000_2026.08.17.26360370v1.63","doi-asserted-by":"publisher","DOI":"10.1002\/aur.70143"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.08.17.26360370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:00:13Z","timestamp":1787400013000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.08.17.26360370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":63,"URL":"https:\/\/doi.org\/10.64898\/2026.08.17.26360370","relation":{},"subject":[],"published":{"date-parts":[[2026,8,19]]},"subtype":"preprint"}}