{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T15:25:09Z","timestamp":1787412309214,"version":"build-2736575974"},"posted":{"date-parts":[[2026,8,20]]},"group-title":"Cancer Biology","reference-count":77,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","award":["1018897"],"award-info":[{"award-number":["1018897"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["3R37CA265967-01A1S1"],"award-info":[{"award-number":["3R37CA265967-01A1S1"]}]},{"name":"National Cancer Institute","award":["R01CA276690"],"award-info":[{"award-number":["R01CA276690"]}]},{"name":"National Cancer Institute","award":["R37CA265967"],"award-info":[{"award-number":["R37CA265967"]}]},{"name":"National Cancer Institute","award":["R01CA251928"],"award-info":[{"award-number":["R01CA251928"]}]},{"name":"National Cancer Institute","award":["K08CA270188"],"award-info":[{"award-number":["K08CA270188"]}]},{"name":"National Cancer Institute","award":["P30CA142543"],"award-info":[{"award-number":["P30CA142543"]}]},{"id":[{"id":"https:\/\/ror.org\/009mk5659","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/030cpmq61","id-type":"ROR","asserted-by":"publisher"}]},{"award":["CA190578"],"award-info":[{"award-number":["CA190578"]}],"id":[{"id":"https:\/\/ror.org\/0447fe631","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Mayo Clinic Foundation"},{"name":"Torrey Coast Foundation"},{"DOI":"10.13039\/100014599","name":"The Mark Foundation for Cancer Research","doi-asserted-by":"crossref","award":["21-003-ELA"],"award-info":[{"award-number":["21-003-ELA"]}],"id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DP1DK139976"],"award-info":[{"award-number":["DP1DK139976"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009634","name":"Susan G. Komen Breast Cancer Foundation","doi-asserted-by":"crossref","award":["1010879"],"award-info":[{"award-number":["1010879"]}],"id":[{"id":"10.13039\/100009634","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  The role of\n                  <jats:italic>ARID1A<\/jats:italic>\n                  in cancer immune evasion remains uncertain, with prior studies reaching opposing conclusions. In addition, previous work has shown that the role of\n                  <jats:italic>ARID1A<\/jats:italic>\n                  in cell-autonomous tumorigenesis is context-dependent. Using isogenic murine gastric cancer models, we found that\n                  <jats:italic>in vivo Arid1a<\/jats:italic>\n                  loss in an autochthonous genetically engineered mouse model of gastric cancer conferred T cell-dependent immune evasion, while\n                  <jats:italic>in vitro<\/jats:italic>\n                  deletion did not. Mechanistically, tumor\n                  <jats:italic>Arid1a<\/jats:italic>\n                  loss reprogrammed the tumor microenvironment into an immune desert through suppression of GM-CSF secretion and interferon-\u03b3 responsiveness. These changes were not observed when\n                  <jats:italic>Arid1a<\/jats:italic>\n                  was deleted\n                  <jats:italic>in vitro<\/jats:italic>\n                  . In human gastric cancer, an immune-cold phenotype was restricted to\n                  <jats:italic>ARID1A<\/jats:italic>\n                  mutants in the genomically stable subtype, while\n                  <jats:italic>ARID1A<\/jats:italic>\n                  loss in the chromosomal instability subtype was associated with variable immune profiles. These results demonstrate that tumor\n                  <jats:italic>ARID1A<\/jats:italic>\n                  loss does not intrinsically confer pro- or anti-tumor immune properties and instead is determined by tissue context.\n                <\/jats:p>","DOI":"10.64898\/2026.08.18.745460","type":"posted-content","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:45:30Z","timestamp":1787237130000},"source":"Crossref","is-referenced-by-count":0,"title":["Tumor context determines\n                  <i>ARID1A<\/i>\n                  effects on gastric cancer immunity"],"prefix":"10.64898","author":[{"given":"Shu","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-9134","authenticated-orcid":false,"given":"Ryan T.","family":"Heslin","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-3194","authenticated-orcid":false,"given":"Morgan F.","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-5776","authenticated-orcid":false,"given":"John D.","family":"Karalis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0855-5708","authenticated-orcid":false,"given":"Nafeesah","family":"Fatimah","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-5116","authenticated-orcid":false,"given":"Shao-Po","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1475-694X","authenticated-orcid":false,"given":"Verena","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn Y.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-1074","authenticated-orcid":false,"given":"Ibrahim","family":"Nassour","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-1266","authenticated-orcid":false,"given":"Skylar L.","family":"Nahi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien Tsung","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjin","family":"Hong","sequence":"additional","affiliation":[{"name":"Center for Computational Systems Biology and Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hyun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Center for Computational Systems Biology and Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA 75390"},{"name":"Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern, Dallas, Texas, USA 75390"},{"name":"Department of Molecular Biology, University of Texas Southwestern, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-8257","authenticated-orcid":false,"given":"Suntrea T.G.","family":"Hammer","sequence":"additional","affiliation":[{"name":"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA 75390"},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA 75390"},{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-5273","authenticated-orcid":false,"given":"Sam C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA 75390"},{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026082208002365000_2026.08.18.745460v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2628"},{"key":"2026082208002365000_2026.08.18.745460v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.03.001"},{"key":"2026082208002365000_2026.08.18.745460v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0012-z"},{"key":"2026082208002365000_2026.08.18.745460v1.4","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk4851"},{"key":"2026082208002365000_2026.08.18.745460v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.04.025"},{"key":"2026082208002365000_2026.08.18.745460v1.6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134402"},{"key":"2026082208002365000_2026.08.18.745460v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34871-9"},{"key":"2026082208002365000_2026.08.18.745460v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-91688-4"},{"key":"2026082208002365000_2026.08.18.745460v1.9","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000438"},{"key":"2026082208002365000_2026.08.18.745460v1.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03326-x"},{"key":"2026082208002365000_2026.08.18.745460v1.11","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.Cir-19-0866"},{"key":"2026082208002365000_2026.08.18.745460v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2025.07.008"},{"key":"2026082208002365000_2026.08.18.745460v1.13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203486"},{"key":"2026082208002365000_2026.08.18.745460v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01111-8"},{"key":"2026082208002365000_2026.08.18.745460v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"2026082208002365000_2026.08.18.745460v1.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801802105"},{"key":"2026082208002365000_2026.08.18.745460v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/nature14415"},{"key":"2026082208002365000_2026.08.18.745460v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.11.004"},{"key":"2026082208002365000_2026.08.18.745460v1.19","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300050"},{"key":"2026082208002365000_2026.08.18.745460v1.20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.001"},{"key":"2026082208002365000_2026.08.18.745460v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.10.007"},{"key":"2026082208002365000_2026.08.18.745460v1.22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328332"},{"key":"2026082208002365000_2026.08.18.745460v1.23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"2026082208002365000_2026.08.18.745460v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90087-6"},{"key":"2026082208002365000_2026.08.18.745460v1.25","doi-asserted-by":"publisher","DOI":"10.1038\/35074122"},{"key":"2026082208002365000_2026.08.18.745460v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/nature21349"},{"key":"2026082208002365000_2026.08.18.745460v1.27","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.Cd-22-1046"},{"key":"2026082208002365000_2026.08.18.745460v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09278-3"},{"key":"2026082208002365000_2026.08.18.745460v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.09.011"},{"key":"2026082208002365000_2026.08.18.745460v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.022"},{"key":"2026082208002365000_2026.08.18.745460v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00566-3"},{"key":"2026082208002365000_2026.08.18.745460v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01872-3"},{"key":"2026082208002365000_2026.08.18.745460v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0705-y"},{"key":"2026082208002365000_2026.08.18.745460v1.34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91190"},{"key":"2026082208002365000_2026.08.18.745460v1.35","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315490"},{"key":"2026082208002365000_2026.08.18.745460v1.36","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2846"},{"key":"2026082208002365000_2026.08.18.745460v1.37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35797-6"},{"key":"2026082208002365000_2026.08.18.745460v1.38","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"2026082208002365000_2026.08.18.745460v1.39","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000002040"},{"key":"2026082208002365000_2026.08.18.745460v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.245"},{"key":"2026082208002365000_2026.08.18.745460v1.41","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04696-z"},{"key":"2026082208002365000_2026.08.18.745460v1.42","unstructured":"FastQC: A Quality Control tool for High Throughput Sequence Data."},{"key":"2026082208002365000_2026.08.18.745460v1.43","unstructured":"Trim Galore!"},{"key":"2026082208002365000_2026.08.18.745460v1.44","unstructured":"Li, H. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. arXiv 1303.3997 (2013)."},{"key":"2026082208002365000_2026.08.18.745460v1.45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"2026082208002365000_2026.08.18.745460v1.46","unstructured":"Picard toolkit (2019)."},{"key":"2026082208002365000_2026.08.18.745460v1.47","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr174"},{"key":"2026082208002365000_2026.08.18.745460v1.48","doi-asserted-by":"crossref","first-page":"9354","DOI":"10.1038\/s41598-019-45839-z","article-title":"The ENCODE Blacklist: Identification of Problematic Regions of the Genome","volume":"9","year":"2019","journal-title":"Scientific Reports"},{"key":"2026082208002365000_2026.08.18.745460v1.49","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"},{"key":"2026082208002365000_2026.08.18.745460v1.50","doi-asserted-by":"crossref","unstructured":"Zhang, Y. et al. Model-based Analysis of ChIP-Seq (MACS). Genome Biology 9, R137 (2008).","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"2026082208002365000_2026.08.18.745460v1.51","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.cels.2020.02.009","article-title":"Quantification, Dynamic Visualization, and Validation of Bias in ATAC-Seq Data with ataqv","volume":"10","year":"2020","journal-title":"Cell Systems"},{"key":"2026082208002365000_2026.08.18.745460v1.52","unstructured":"DiffBind: Differential binding analysis of ChIP-Seq peak data (2011)."},{"key":"2026082208002365000_2026.08.18.745460v1.53","doi-asserted-by":"publisher","DOI":"10.1038\/nature10730"},{"key":"2026082208002365000_2026.08.18.745460v1.54","doi-asserted-by":"crossref","unstructured":"Zhu, L. J. in Tiling Arrays: Methods and Protocols (eds T. L. Lee & A. C. Shui Luk ) 105\u2013124 (Humana Press, 2013).","DOI":"10.1007\/978-1-62703-607-8_8"},{"key":"2026082208002365000_2026.08.18.745460v1.55","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-237"},{"key":"2026082208002365000_2026.08.18.745460v1.56","doi-asserted-by":"crossref","unstructured":"Hahne, F. & Ivanek, R. in Statistical Genomics: Methods and Protocols (eds E. Math\u00e9 & S. Davis ) 335\u2013351 (Springer, 2016).","DOI":"10.1007\/978-1-4939-3578-9_16"},{"key":"2026082208002365000_2026.08.18.745460v1.57","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2026082208002365000_2026.08.18.745460v1.58","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"2026082208002365000_2026.08.18.745460v1.59","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026082208002365000_2026.08.18.745460v1.60","unstructured":"Korotkevich, G. , Sukhov, V. , Budin, N. , Shpak, B. , Artyomov, M.N. , & Sergushichev, A."},{"key":"2026082208002365000_2026.08.18.745460v1.61","unstructured":"Liberzon, A. , Birger, C. , Thorvaldsd\u00f3ttir, H. , Ghandi, M. , Mesirov, J.P. , & Tamayo, P."},{"key":"2026082208002365000_2026.08.18.745460v1.62","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"2026082208002365000_2026.08.18.745460v1.63","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7563.2"},{"key":"2026082208002365000_2026.08.18.745460v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.97"},{"key":"2026082208002365000_2026.08.18.745460v1.65","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0095"},{"key":"2026082208002365000_2026.08.18.745460v1.66","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004088"},{"key":"2026082208002365000_2026.08.18.745460v1.67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082099299"},{"key":"2026082208002365000_2026.08.18.745460v1.68","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"2026082208002365000_2026.08.18.745460v1.69","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8999"},{"key":"2026082208002365000_2026.08.18.745460v1.70","unstructured":"Carlson, M. Vol. 3.16.0 (Bioconductor, 2022)."},{"key":"2026082208002365000_2026.08.18.745460v1.71","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"2026082208002365000_2026.08.18.745460v1.72","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1874-1"},{"key":"2026082208002365000_2026.08.18.745460v1.73","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02584-9"},{"key":"2026082208002365000_2026.08.18.745460v1.74","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa1009"},{"key":"2026082208002365000_2026.08.18.745460v1.75","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"2026082208002365000_2026.08.18.745460v1.76","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1802.03426"},{"key":"2026082208002365000_2026.08.18.745460v1.77","doi-asserted-by":"publisher","DOI":"10.1088\/1742-5468\/2008\/10\/p10008"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.08.18.745460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T15:00:35Z","timestamp":1787410835000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.08.18.745460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":77,"URL":"https:\/\/doi.org\/10.64898\/2026.08.18.745460","relation":{},"subject":[],"published":{"date-parts":[[2026,8,20]]},"subtype":"preprint"}}