{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:07:22Z","timestamp":1788898042442,"version":"build-2803163510"},"posted":{"date-parts":[[2026,9,3]]},"group-title":"Neuroscience","reference-count":87,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["AA031074"],"award-info":[{"award-number":["AA031074"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["MH128763"],"award-info":[{"award-number":["MH128763"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NS141747"],"award-info":[{"award-number":["NS141747"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Alcohol misuse is a leading cause of preventable death worldwide. Chronic alcohol is associated with disrupted circadian rhythms, yet molecular mechanisms linking circadian rhythm dysregulation and alcohol consumption are poorly understood. Current FDA-approved treatments for alcohol use disorder (AUD) do not target molecular rhythms or sleep-wake cycles. Mammalian circadian rhythms are regulated by transcription-translation feedback loops that regulate expression of \u2018clock genes\u2019 (e.g.,\n                  <jats:italic>Arntl<\/jats:italic>\n                  encoding for BMAL1). Both human and rodent studies demonstrate associations between clock gene variants and changes in reward-seeking behavior. Evidence suggests astrocytes, non-neuronal brain cells with cell-autonomous rhythms, may regulate both circadian rhythms and reward. In the nucleus accumbens (NAc), a region responsible for modulating alcohol- and reward-related behavior, over 43% of the astrocyte transcriptome is expressed rhythmically. However, no studies to date have investigated roles of NAc astrocyte rhythmicity in regulating alcohol drinking. We used AAV8-Gfap-Cre to functionally ablate molecular rhythms in NAc astrocytes of BMAL1 floxed mice. Two-bottle choice (2BC), drinking-in-the-light (DIL), and drinking-in-the-dark (DID) assessed alcohol drinking. Behavioral assays included locomotor response to novelty, sucrose preference, and social interaction. Disrupting molecular clock function in NAc astrocytes increased binge-like drinking during both DIL and DID paradigms (\n                  <jats:italic>d<\/jats:italic>\n                  = 1.44), but not with any other drinking paradigm or behavior. This study carves out a unique role for astrocytes in controlling the temporal organization of reward circuitry and susceptibility to binge-drinking. Future studies will investigate clock-controlled astrocyte mechanisms, such as glutamate uptake and ATP release, that may underlie binge-like drinking behavior.\n                <\/jats:p>","DOI":"10.64898\/2026.08.28.747847","type":"posted-content","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:45:24Z","timestamp":1788497124000},"source":"Crossref","is-referenced-by-count":0,"title":["Astrocyte molecular rhythm disruption in nucleus accumbens promotes increased binge-like drinking in mice"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0132-6309","authenticated-orcid":false,"given":"Tori","family":"Keefauver","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Translational Neuroscience Program, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"},{"name":"Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-0063","authenticated-orcid":false,"given":"Nicole L.","family":"Horan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Translational Neuroscience Program, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7589-6828","authenticated-orcid":false,"given":"Nicole J.","family":"Fairbanks","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Translational Neuroscience Program, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Translational Neuroscience Program, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Translational Neuroscience Program, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-015X","authenticated-orcid":false,"given":"Ryan W.","family":"Logan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of Massachusetts Chan Medical School, Worcester, MA 06155, USA"},{"name":"Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 06155, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-8153","authenticated-orcid":false,"given":"Gregg E.","family":"Homanics","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-1984","authenticated-orcid":false,"given":"Sean P.","family":"Farris","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"},{"name":"Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-9494","authenticated-orcid":false,"given":"Marianne L.","family":"Seney","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Translational Neuroscience Program, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-5811","authenticated-orcid":false,"given":"Kyle D.","family":"Ketchesin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Translational Neuroscience Program, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026090812200419000_2026.08.28.747847v1.1","unstructured":"Organization, WH, Global status report on alcohol and health treatment of substance use disorders. 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