{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:09Z","timestamp":1792790349233,"version":"4.5.0"},"posted":{"date-parts":[[2026,8,31]]},"group-title":"Systems Biology","reference-count":22,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"National Institute of Health, Bethesda, USA","award":["R01AG060477"],"award-info":[{"award-number":["R01AG060477"]}]},{"name":"National Institute of Health, Bethesda, USA","award":["R01AG064314"],"award-info":[{"award-number":["R01AG064314"]}]},{"name":"Rainwater Charitable Foundation","id":[{"id":"https:\/\/ror.org\/003q4qk22","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The John Madden Family"},{"name":"The Prospect Creek Foundation","id":[{"id":"https:\/\/ror.org\/05pnphj78","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>We identified Intermittent Cranial Accelerometric Pulses (ICAPs) also known as \u201cSleep Bursts\u201d (SBs), as a novel phenomenon of brief (1-2 sec), often periodic bursts in cranial forces occurring during human sleep. Our goal was to characterize SBs in normal subjects, then compare SB in a cohort of subjects with neurodegenerative disease (NDD). We recorded 32 cognitively healthy subjects (23-87 years) and 13 subjects with NDD (51 \u2013 84 years). SBs occurred in all 45 subjects. SBs occurred at 0.57 SB\/min (once per 105 seconds) in controls and 0.40 SB\/min (once per 150 seconds) in NDD (p = 0.0043). SB occurred with equal rates across all sleep stages in both groups. When occurring periodically, SBs had modal intervals (3.75 bursts\/min (0.0625 Hz) - 2.67 bursts\/min (0.044 Hz)). EEG power increased in the delta range 1-2 seconds before and following the SB. EEG delta power during a SB was significantly lower in all NDD subjects across sleep stages compared to controls. The relatively low frequency of SB events and synchronization with EEG power has no parallel in human sleep; we hypothesize that SBs may represent a brain-generated pulsatile component of brain glymphatic drainage.<\/jats:p>","DOI":"10.64898\/2026.08.28.747878","type":"posted-content","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T19:40:18Z","timestamp":1788205218000},"source":"Crossref","is-referenced-by-count":0,"title":["Intermittent Cranial Accelerometric Pulses - a Potential Marker of Neurodegenerative Disease"],"prefix":"10.64898","author":[{"given":"Christine M.","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Lovoi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Yack","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Francisco; San Francisco, USA"},{"name":"San Francisco Veterans Affairs Medical Center; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"},{"name":"University of California Los Angeles; Los Angeles, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Pandher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliot D.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hemphill","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominica","family":"Randazzo","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Woodward","sequence":"additional","affiliation":[{"name":"National Center for PTSD, Dissemination and Training Division, VA Palo Alto Health Care System; Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Neylan","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"},{"name":"Department of Psychiatry University of California San Francisco; San Francisco, USA"},{"name":"San Francisco Veterans Affairs Medical Center; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco; San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026093008400893000_2026.08.28.747878v2.1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04285"},{"key":"2026093008400893000_2026.08.28.747878v2.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201795119"},{"key":"2026093008400893000_2026.08.28.747878v2.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.031"},{"key":"2026093008400893000_2026.08.28.747878v2.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002263"},{"key":"2026093008400893000_2026.08.28.747878v2.5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fpsyt.2018.00303","article-title":"Severe Sleep Deprivation Causes Hallucinations and a Gradual Progression Toward Psychosis With Increasing Time Awake","volume":"9","year":"2018","journal-title":"Front Psychiatry"},{"key":"2026093008400893000_2026.08.28.747878v2.6","doi-asserted-by":"crossref","unstructured":"H. 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