{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:31:04Z","timestamp":1789129864673,"version":"build-2803163510"},"posted":{"date-parts":[[2026,9,8]]},"group-title":"Neurology","reference-count":23,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R01NS104423"],"award-info":[{"award-number":["R01NS104423"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/03zj4c476","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/03arq3225","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Impulse control disorders (ICDs) are clinically important nonmotor features of Parkinson\u2019s disease (PD). Tremor-dominant PD (TD-PD) has been associated with greater cerebello-thalamo-cortical involvement, whereas postural instability\/gait difficulty-dominant PD (PIGD-PD) has been linked to more prominent basal ganglia and frontostriatal dysfunction. We therefore examined whether ICD symptoms differ by motor phenotypes.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study analyzed baseline data from the Parkinson\u2019s Precision Medicine Initiative (PPMI). Motor subtype classification was based on Movement Disorder Society-Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS) criteria. ICD symptoms were assessed using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson\u2019s Disease-Current Short Form (QUIP-CS) and evaluated across multiple levels of analysis using the standard screening definition and normalized QUIP-CS scores analyzed categorically and continuously. Temporal-alignment, subgroup, multivariable, and Bayesian analyses were performed to assess the robustness of the primary findings.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    We analyzed 305 participants (173 TD-PD, 132 PIGD-PD). Screening-defined ICD positivity was similar between subtypes (21.4% vs 21.2%, OR = 1.01, 95% CI 0.58-1.76,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.970). Continuous and categorical normalized QUIP-CS scores likewise did not differ between groups (continuous score: 0.0338 vs 0.0384,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.674; categorical score: 3.5% vs 4.5%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.632). Temporally aligned, subgroup, and multivariable sensitivity analyses consistently supported the primary finding, and Bayesian analysis provided moderate evidence supporting the null hypothesis (BF\n                    <jats:sub>01<\/jats:sub>\n                    = 7.21).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ICD symptoms do not differ between TD-PD and PIGD-PD motor subtypes in early PD. These findings suggest that motor subtype-associated differences in cerebellar involvement do not substantially influence ICD symptoms in early PD.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.09.04.26362266","type":"posted-content","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:50:17Z","timestamp":1788886217000},"source":"Crossref","is-referenced-by-count":0,"title":["Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9233-7994","authenticated-orcid":false,"given":"M. Eymaz","family":"Chhotani","sequence":"first","affiliation":[{"name":"Department of Neurology, Baylor College of Medicine, Houston, TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Saban","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, Gray Faculty of Medical & Health Sciences, Sagol School of Neuroscience, Center for Accessible Neuropsychology, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malco","family":"Rossi","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Movimientos Anormales, Departamento de Neurolog\u00eda, Fleni, Buenos Aires, Argentina; Instituto Fleni-CONICET (INEU), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Han","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Montaser-Kouhsari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Harvard University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-974X","authenticated-orcid":false,"given":"Chi-Ying R.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baylor College of Medicine, Houston, TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026091104350868000_2026.09.04.26362266v1.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085747"},{"key":"2026091104350868000_2026.09.04.26362266v1.2","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13839"},{"key":"2026091104350868000_2026.09.04.26362266v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2025.106026"},{"key":"2026091104350868000_2026.09.04.26362266v1.4","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22571"},{"key":"2026091104350868000_2026.09.04.26362266v1.5","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.n92ldmw6ol5b\/v2"},{"key":"2026091104350868000_2026.09.04.26362266v1.6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.10.1529"},{"key":"2026091104350868000_2026.09.04.26362266v1.7","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"2026091104350868000_2026.09.04.26362266v1.8","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13107"},{"key":"2026091104350868000_2026.09.04.26362266v1.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-022-02531-9"},{"key":"2026091104350868000_2026.09.04.26362266v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00377-w"},{"key":"2026091104350868000_2026.09.04.26362266v1.11","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23697"},{"key":"2026091104350868000_2026.09.04.26362266v1.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-015-1490-5"},{"key":"2026091104350868000_2026.09.04.26362266v1.13","doi-asserted-by":"publisher","DOI":"10.1111\/jon.70020"},{"key":"2026091104350868000_2026.09.04.26362266v1.14","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0000000000000409"},{"key":"2026091104350868000_2026.09.04.26362266v1.15","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303056"},{"key":"2026091104350868000_2026.09.04.26362266v1.16","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00279"},{"key":"2026091104350868000_2026.09.04.26362266v1.17","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28625"},{"key":"2026091104350868000_2026.09.04.26362266v1.18","doi-asserted-by":"publisher","DOI":"10.1002\/mds.30229"},{"key":"2026091104350868000_2026.09.04.26362266v1.19","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01777-2"},{"key":"2026091104350868000_2026.09.04.26362266v1.20","doi-asserted-by":"publisher","DOI":"10.1111\/jnp.12415"},{"key":"2026091104350868000_2026.09.04.26362266v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105359"},{"key":"2026091104350868000_2026.09.04.26362266v1.22","unstructured":"JASP Team. 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