{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:07:41Z","timestamp":1789157261522,"version":"build-2803163510"},"posted":{"date-parts":[[2026,9,8]]},"group-title":"Biophysics","reference-count":56,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["R35GM162296"],"award-info":[{"award-number":["R35GM162296"]}]},{"DOI":"10.13039\/100000879","name":"Alfred P. 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We find that the two condensates exhibit markedly different client partitioning profiles and transport dynamics. In the heterogeneous condensate, clients sample distinct local microenvironments in a size-dependent manner, leading to pronounced differences in their transfer free energy compared with the homogeneous condensate. The heterogeneous internal organization also generates local environments with different mobilities and constraints, giving rise to transient subdiffusion and non-Gaussian displacement distributions in client motion. Our results identify mesoscale organization as an important physical factor controlling both molecular selectivity and transport in biomolecular condensates, with implications for the biochemical functions of both natural and engineered systems.<\/jats:p>","DOI":"10.64898\/2026.09.05.749622","type":"posted-content","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:40:16Z","timestamp":1788864016000},"source":"Crossref","is-referenced-by-count":0,"title":["Mesoscale Heterogeneity Shapes Molecular Selectivity and Transport in Biomolecular Condensates"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1041-0778","authenticated-orcid":false,"given":"Vladimir","family":"Grigorev","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218, 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