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Additional strategies promoting anti-tumor immunity are needed. Using the MMTV-PyMT intratibial model of breast cancer bone metastasis, we discovered that deletion of host short-form Ron (Ron SF\n                  <jats:sup>-\/-<\/jats:sup>\n                  ) protected against bone metastatic outgrowth by promoting strong infiltration of lymphocytes, including B cells, into tumors at the micrometastasis stage. Transcriptionally, Ron SF\n                  <jats:sup>-\/-<\/jats:sup>\n                  B cells were more active and inflammatory compared to wildtype. Elimination of mature B cells (JH\n                  <jats:sup>-\/-<\/jats:sup>\n                  ) rescued tumor growth in Ron SF\n                  <jats:sup>-\/-<\/jats:sup>\n                  mice, indicating that mature B cells were necessary for anti-tumor immunity and protection against bone metastasis. In Ron SF\n                  <jats:sup>-\/-<\/jats:sup>\n                  hosts, T follicular helper (Tfh) cells were abundant in tumor-enriched regions of bone, suggesting interactions between B and T cells. B-T cell cooperation was further supported by attenuation of CD4 and CD8 T cell tumor infiltration in Ron SF\n                  <jats:sup>-\/-<\/jats:sup>\n                  JH\n                  <jats:sup>-\/-<\/jats:sup>\n                  hosts and, conversely, diminished B cell tumor infiltration and rescue of tumor growth in Ron SF\n                  <jats:sup>-\/-<\/jats:sup>\n                  hosts lacking CD4 or CD8 T cells. B cells were not required to protect Ron SF\n                  <jats:sup>-\/-<\/jats:sup>\n                  mice from lung metastasis, indicating a tissue-dependent anti-tumor role for B cells. These data support a positive feedback loop between B and T cells regulated by SF-Ron and reveal the anti-tumor potential of B cells in the bone.\n                <\/jats:p>","DOI":"10.64898\/2026.09.05.749628","type":"posted-content","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:00:10Z","timestamp":1789066810000},"source":"Crossref","is-referenced-by-count":0,"title":["Loss of short-form Ron promotes B and T cell cooperation to prevent outgrowth of breast cancer bone metastasis"],"prefix":"10.64898","author":[{"given":"Clint H.","family":"Valencia","sequence":"first","affiliation":[{"name":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Nadjsombati","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truc","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Soltero","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navina","family":"Devarajan","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Fornetti","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-1351","authenticated-orcid":false,"given":"Alana L.","family":"Welm","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, University of Utah, Salt Lake City, Utah"},{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026091306000686000_2026.09.05.749628v1.1","unstructured":"American Cancer Society. 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