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Murphy Endowment Fund"],"award-info":[{"award-number":["Charles B.G. Murphy Endowment Fund"]}],"id":[{"id":"https:\/\/ror.org\/03v76x132","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>Cooperation is typically studied as an output of the social brain, as opposed to an experience that shapes it. Here, we developed a task in rats that permits interaction while requiring joint action for reward. Cooperation depended on partner familiarity and visual access. Anterior cingulate cortex (ACC) to basolateral amygdala (BLA) projections were activated during cooperation with a familiar partner, whereas ACC to anterior insula (AI) projections were simultaneously suppressed regardless of familiarity. Using synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET), we found that a single 90 min cooperative experience increased presynaptic density in the amygdala and insula one day later. Cooperative experience enhanced subsequent responding toward a distressed conspecific, in proportion to the amount of cooperation. Cooperation is thus an experience that recruits dissociable corticolimbic pathways and changes brain and behavior beyond the encounter itself.<\/jats:p>","DOI":"10.64898\/2026.09.07.749944","type":"posted-content","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:40:12Z","timestamp":1789414812000},"source":"Crossref","is-referenced-by-count":0,"title":["Cooperation recruits corticolimbic projections and induces synaptic change in rats"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-0546","authenticated-orcid":false,"given":"Henry W.","family":"Kietzman","sequence":"first","affiliation":[{"name":"Neuroscience Research Training Program (NRTP), Department of Psychiatry, Yale University, New Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University, New Haven, CT, USA"},{"name":"Wu Tsai Institute, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Allie Cauchon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA"},{"name":"Wu Tsai Institute, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Backer Peral","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Yale University, New Haven, CT, USA"},{"name":"Wu Tsai Institute, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Bonomi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-3775","authenticated-orcid":false,"given":"Yiyun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA"},{"name":"Yale Positron Emission Tomography Center, Yale School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayde","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alya","family":"Bagdas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA"},{"name":"Department of Electrical and Computer Engineering, Yale University, New Haven, CT, USA"},{"name":"Wu Tsai Institute, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-710X","authenticated-orcid":false,"given":"S. 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