{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:07:01Z","timestamp":1789474021040,"version":"build-2803163510"},"posted":{"date-parts":[[2026,9,10]]},"group-title":"Epidemiology","reference-count":62,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R01CA244670"],"award-info":[{"award-number":["R01CA244670"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32CA009168"],"award-info":[{"award-number":["T32CA009168"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Observational studies have identified associations between circulating inflammatory markers (CIMs) and mammographic density (MD) phenotypes, but whether these associations reflect causal effects remains unclear. We utilized two-sample Mendelian randomization (MR) to assess relationships between 60 CIMs and MD phenotypes in individuals of European genetic ancestry by examining associations between genetically predicted CIM concentrations and three MD phenotypes (dense area, DA:\n                  <jats:italic>N<\/jats:italic>\n                  = 13,965; non-dense area, NDA:\n                  <jats:italic>N<\/jats:italic>\n                  = 14,036; percent density, PMD:\n                  <jats:italic>N<\/jats:italic>\n                  = 17,841). Primary analyses were conducted using the inverse variance weighted MR method. No CIM-MD phenotype associations reached statistical significance after correction for multiple testing. At a nominal significance level of\n                  <jats:italic>p<\/jats:italic>\n                  &lt; 0.05, we observed suggestive evidence for eight associations represented by six unique CIMs (MD phenotype\/direction of association): CCL23 (DA\/+), CD40 (NDA\/-), GDNF (DA\/+ &amp; PMD\/+), MMP-10 (DA\/+ &amp; PMD\/+), TRANCE (DA\/-), and TWEAK (NDA\/+). In multivariable MR analyses accounting for body mass index (BMI), we observed six nominal associations represented by six unique CIMs, although most instruments demonstrated weak conditional instrument strength after inclusion of BMI. Overall, our comprehensive analysis of 60 CIMs provides limited evidence supporting broad causal effects of circulating inflammatory markers contributing to variation in MD phenotypes.\n                <\/jats:p>","DOI":"10.64898\/2026.09.08.26362541","type":"posted-content","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:10:19Z","timestamp":1789143019000},"source":"Crossref","is-referenced-by-count":0,"title":["Circulating Inflammatory Markers and Mammographic Density Phenotypes: a Mendelian Randomization Analysis"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-2202","authenticated-orcid":false,"given":"Austin Hammermeister","family":"Suger","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha A.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron B.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqi","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjeet K.","family":"Bolla","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Dennis","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Michailidou","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Dunning","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK"},{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Southey","sequence":"additional","affiliation":[{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"},{"name":"Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Department of Medicine, St Vincent\u2019s Hospital, The University of Melbourne, Fitzroy, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Fasching","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Haeberle","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Stone","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Group, School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Gago-Dominguez","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Epidemiology Group, Genomic Medicine Group, Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E.","family":"Castelao","sequence":"additional","affiliation":[{"name":"Oncology and Genetics Unit, Instituto de Investigaci\u00f3n Sanitaria Galicia Sur, SERGAS, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristan","family":"Aronson","sequence":"additional","affiliation":[{"name":"Public Health Sciences, Queen\u2019s University, Kingston, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Murphy","sequence":"additional","affiliation":[{"name":"School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada"},{"name":"Population Health Sciences, BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"},{"name":"North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary\u2019s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherene","family":"Loi","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia"},{"name":"The Sir Peter MacCallum Department of Medical Oncology, The University of Melbourne, Parkville, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"kConFab Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus J.","family":"Couch","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Haiman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M.","family":"John","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology & Population Health and of Medicine (Oncology), Stanford University School of Medicine, Stanford, CA, USA"},{"name":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Marie","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vessela N.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"University of Connecticut, Storrs, CT, USA"},{"name":"Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Heather","family":"Eliassen","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"},{"name":"Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[{"name":"Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonine D.","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK"},{"name":"Cancer Research UK Edinburgh Centre, The University of Edinburgh, Edinburgh, UK"},{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Astley","sequence":"additional","affiliation":[{"name":"Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Czene","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.P.","family":"Pharoah","sequence":"additional","affiliation":[{"name":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis C.","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Garc\u00eda-Closas","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research (ICR), London, UK"},{"name":"Cancer Epidemiology and Prevention Research Unit, The Institute of Cancer Research (ICR) and Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Berrington","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research (ICR), London, UK"},{"name":"Cancer Epidemiology and Prevention Research Unit, The Institute of Cancer Research (ICR) and Imperial College London, London, UK"},{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen L.","family":"Gierach","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine M.","family":"Vachon","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulla M.","family":"Tamimi","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA"},{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026091504501449000_2026.09.08.26362541v1.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"2026091504501449000_2026.09.08.26362541v1.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"2026091504501449000_2026.09.08.26362541v1.3","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-1175"},{"key":"2026091504501449000_2026.09.08.26362541v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.09.007"},{"key":"2026091504501449000_2026.09.08.26362541v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41356-2"},{"key":"2026091504501449000_2026.09.08.26362541v1.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.5534"},{"key":"2026091504501449000_2026.09.08.26362541v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.12.049"},{"key":"2026091504501449000_2026.09.08.26362541v1.8","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"2026091504501449000_2026.09.08.26362541v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.06.003"},{"key":"2026091504501449000_2026.09.08.26362541v1.10","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv169"},{"key":"2026091504501449000_2026.09.08.26362541v1.11","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2023.132"},{"key":"2026091504501449000_2026.09.08.26362541v1.12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00754"},{"key":"2026091504501449000_2026.09.08.26362541v1.13","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/653045"},{"key":"2026091504501449000_2026.09.08.26362541v1.14","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0187"},{"key":"2026091504501449000_2026.09.08.26362541v1.15","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-020-01329-6"},{"key":"2026091504501449000_2026.09.08.26362541v1.16","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2024.2762"},{"key":"2026091504501449000_2026.09.08.26362541v1.17","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-11931-5"},{"key":"2026091504501449000_2026.09.08.26362541v1.18","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17155445"},{"key":"2026091504501449000_2026.09.08.26362541v1.19","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09975-6"},{"key":"2026091504501449000_2026.09.08.26362541v1.20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1106520"},{"key":"2026091504501449000_2026.09.08.26362541v1.21","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1249-5"},{"key":"2026091504501449000_2026.09.08.26362541v1.22","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000794"},{"key":"2026091504501449000_2026.09.08.26362541v1.23","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1229723"},{"key":"2026091504501449000_2026.09.08.26362541v1.24","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-019-01206-x"},{"key":"2026091504501449000_2026.09.08.26362541v1.25","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-015-0522-7"},{"key":"2026091504501449000_2026.09.08.26362541v1.26","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12003"},{"key":"2026091504501449000_2026.09.08.26362541v1.27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1064"},{"key":"2026091504501449000_2026.09.08.26362541v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.137"},{"key":"2026091504501449000_2026.09.08.26362541v1.29","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"2026091504501449000_2026.09.08.26362541v1.30","unstructured":"MRC IEU UK Biobank GWAS pipeline version 2. In: University of Bristol [Internet]. [cited 6 Mar 2025]. Available: https:\/\/research-information.bris.ac.uk\/en\/datasets\/mrc-ieu-uk-biobank-gwas-pipeline-version-2"},{"key":"2026091504501449000_2026.09.08.26362541v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29650-5"},{"key":"2026091504501449000_2026.09.08.26362541v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00287-2"},{"key":"2026091504501449000_2026.09.08.26362541v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01588-w"},{"key":"2026091504501449000_2026.09.08.26362541v1.34","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"2026091504501449000_2026.09.08.26362541v1.35","doi-asserted-by":"publisher","DOI":"10.1101\/2020.08.10.244293"},{"key":"2026091504501449000_2026.09.08.26362541v1.36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1120"},{"key":"2026091504501449000_2026.09.08.26362541v1.37","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07306-w"},{"key":"2026091504501449000_2026.09.08.26362541v1.38","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy262"},{"key":"2026091504501449000_2026.09.08.26362541v1.39","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9133"},{"key":"2026091504501449000_2026.09.08.26362541v1.40","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2023. Available: https:\/\/www.R-project.org\/"},{"key":"2026091504501449000_2026.09.08.26362541v1.41","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"2026091504501449000_2026.09.08.26362541v1.42","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"2026091504501449000_2026.09.08.26362541v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"2026091504501449000_2026.09.08.26362541v1.44","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv402"},{"key":"2026091504501449000_2026.09.08.26362541v1.45","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu283"},{"key":"2026091504501449000_2026.09.08.26362541v1.46","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.19995.2"},{"key":"2026091504501449000_2026.09.08.26362541v1.47","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0255-x"},{"key":"2026091504501449000_2026.09.08.26362541v1.48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222362"},{"key":"2026091504501449000_2026.09.08.26362541v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.05.014"},{"key":"2026091504501449000_2026.09.08.26362541v1.50","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"2026091504501449000_2026.09.08.26362541v1.51","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124122"},{"key":"2026091504501449000_2026.09.08.26362541v1.52","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21813"},{"key":"2026091504501449000_2026.09.08.26362541v1.53","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000001233"},{"key":"2026091504501449000_2026.09.08.26362541v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-025-00889-7"},{"key":"2026091504501449000_2026.09.08.26362541v1.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.10.010"},{"key":"2026091504501449000_2026.09.08.26362541v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50071-z"},{"key":"2026091504501449000_2026.09.08.26362541v1.57","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.622588"},{"key":"2026091504501449000_2026.09.08.26362541v1.58","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17030337"},{"key":"2026091504501449000_2026.09.08.26362541v1.59","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-9924-5"},{"key":"2026091504501449000_2026.09.08.26362541v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2025.100412"},{"key":"2026091504501449000_2026.09.08.26362541v1.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.104991"},{"key":"2026091504501449000_2026.09.08.26362541v1.62","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400140"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.09.08.26362541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:50:24Z","timestamp":1789473024000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.09.08.26362541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":62,"URL":"https:\/\/doi.org\/10.64898\/2026.09.08.26362541","relation":{},"subject":[],"published":{"date-parts":[[2026,9,10]]},"subtype":"preprint"}}