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We developed WEARIT (\n                  <jats:bold>W<\/jats:bold>\n                  ireless\n                  <jats:bold>E<\/jats:bold>\n                  quipment for\n                  <jats:bold>A<\/jats:bold>\n                  utonomous\n                  <jats:bold>R<\/jats:bold>\n                  at\n                  <jats:bold>I<\/jats:bold>\n                  nfusion\n                  <jats:bold>T<\/jats:bold>\n                  asks), a wearable, tetherless infusion platform that gives freely moving rats intravenous access under either remote or closed-loop operant control. The device houses a reservoir, miniaturized pump, rechargeable battery and Bluetooth circuitry in a 3D-printed enclosure worn on the back. By measuring spontaneous locomotion, amphetamine-induced hyperlocomotion and food-reinforced operant responding, we show that WEARIT leaves these behaviors unchanged. Remotely triggered fentanyl infusions yielded reliable delivery with physiological responses confirmed by pulse oximetry, and self-administration acquisition and dose\u2013response functions were comparable to conventional tethered systems. WEARIT removes a longstanding constraint on intravenous pharmacology, opening self-administration paradigms to naturalistic and enriched environments and to concurrent imaging or optogenetic manipulation of the circuits engaged by drug reinforcement.\n                <\/jats:p>","DOI":"10.64898\/2026.09.08.750146","type":"posted-content","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:00:11Z","timestamp":1789426811000},"source":"Crossref","is-referenced-by-count":0,"title":["A Wireless Wearable Platform for Intravenous Drug Self-Administration in Freely Behaving Rats"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-6618","authenticated-orcid":false,"given":"Eun Young","family":"Jeong","sequence":"first","affiliation":[{"name":"School of Electrical Engineering, Korea Advanced Institute of Science and 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