{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:23Z","timestamp":1792790363282,"version":"4.5.0"},"posted":{"date-parts":[[2026,9,11]]},"group-title":"Neurology","reference-count":54,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH National Center for Advancing Translational Sciences","award":["K12TR004364"],"award-info":[{"award-number":["K12TR004364"]}],"id":[{"id":"https:\/\/ror.org\/04pw6fb54","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development","award":["P2CHD101899"],"award-info":[{"award-number":["P2CHD101899"]}],"id":[{"id":"https:\/\/ror.org\/04byxyr05","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development","award":["R25HD105583"],"award-info":[{"award-number":["R25HD105583"]}],"id":[{"id":"https:\/\/ror.org\/04byxyr05","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Parkinson\u2019s Disease (PD) motor features typically begin unilaterally, but it remains unclear whether dominant versus non-dominant side motor symptoms differentially affect lateralized aspects of fine motor control.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We recruited 16 right-handed participants with mild, asymmetric PD (8 primarily left-side affected, 8 primarily right-side affected) and 10 age-matched controls to complete a bimanual tablet task in which one hand draws a stylus to targets (leveraging trajectory control mechanisms) while the other hand simultaneously stabilizes a stylus over a stationary target (leveraging stabilizing control mechanisms). The styli are connected via a resistance band to mimic internal forces that arise during asymmetric, bimanual activities of daily living.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Both PD groups demonstrated preserved trajectory control in their dominant hand relative to controls (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; .072), but significantly impaired stabilizing control in their non-dominant hand (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; .022), with the largest deficits observed in the left-side PD group. Trajectory control performance significantly correlated with an overall measure of motor severity (\n                    <jats:italic>r<\/jats:italic>\n                    (14) = .69;\n                    <jats:italic>p<\/jats:italic>\n                    = .004), while stabilizing control did not (\n                    <jats:italic>p<\/jats:italic>\n                    = .56).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>These findings suggest that left- and right-side motor symptoms in early PD produce distinct patterns of functional impairment (rather than simple contralateral analogs) that may be related to underlying lateralized motor control mechanisms. This work highlights a potential gap in standard clinical motor assessments, which may not adequately capture non-dominant side stabilizing deficits in early PD.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.09.09.26362567","type":"posted-content","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:10:19Z","timestamp":1789193419000},"source":"Crossref","is-referenced-by-count":0,"title":["Lateralized motor control mechanisms underlie lateralized motor deficits in early Parkinson\u2019s Disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-8992","authenticated-orcid":false,"given":"Brooke","family":"Dexheimer","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Selb","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, Virginia 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