{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:04:17Z","timestamp":1789553057267,"version":"build-2803163510"},"posted":{"date-parts":[[2026,9,11]]},"group-title":"Health Informatics","reference-count":26,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["U24 CA265879"],"award-info":[{"award-number":["U24 CA265879"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Oncology knowledge spans structured and unstructured datasets of drugs, regimens, conditions, and identifiers, as well as clinician-authored narratives describing treatment sequencing across disease settings. Answering clinical questions may require accessing both databases and free-text narratives, but existing intelligent retrieval systems favor either relational facts or narrative context. We developed HemOncAgent, an artificial intelligence agent that selects among retrieval tools for the HemOnc knowledge ecosystem: HemOncKB, a curated knowledge graph for pharmacologic relationships, and\n                  <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/HemOnc.org\">HemOnc.org<\/jats:ext-link>\n                  , a narrative resource for care pathways. Across structured and narrative benchmarks, HemOncAgent maintained high-fidelity retrieval across question types for which single-source systems showed domain-specific limitations, supporting hybrid tool-based retrieval for more reliable oncology knowledge access.\n                <\/jats:p>","DOI":"10.64898\/2026.09.09.26362651","type":"posted-content","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:20:22Z","timestamp":1789183222000},"source":"Crossref","is-referenced-by-count":0,"title":["HemOncAgent: an artificial intelligence system for retrieving structured and narrative oncology knowledge"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0072-3441","authenticated-orcid":false,"given":"Andrew J","family":"Yang","sequence":"first","affiliation":[{"name":"The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2391-2689","authenticated-orcid":false,"given":"Hossam A","family":"Zaki","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4423-5587","authenticated-orcid":false,"given":"Aaron","family":"Seto","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3438-3988","authenticated-orcid":false,"given":"Taemin","family":"Kim","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-0311","authenticated-orcid":false,"given":"Irbaz Bin","family":"Riaz","sequence":"additional","affiliation":[{"name":"Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-8726","authenticated-orcid":false,"given":"Andrew","family":"Srisuwananukorn","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-2727","authenticated-orcid":false,"given":"Andrew J","family":"Cowan","sequence":"additional","affiliation":[{"name":"BC Cancer\/University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-9543","authenticated-orcid":false,"given":"Peter C","family":"Yang","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-7242","authenticated-orcid":false,"given":"Jeremy L","family":"Warner","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University, Providence, RI, USA"},{"name":"Center for Clinical Cancer Informatics and Data Science, Legorreta Cancer Center, Brown University, Providence, RI, USA"},{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026091602201232000_2026.09.09.26362651v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103239"},{"key":"2026091602201232000_2026.09.09.26362651v1.2","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2014.001511"},{"key":"2026091602201232000_2026.09.09.26362651v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03423-7"},{"key":"2026091602201232000_2026.09.09.26362651v1.4","unstructured":"Nori H , King N , McKinney SM , Carignan D , Horvitz E. 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