{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:03:10Z","timestamp":1789794190552,"version":"4.0.1"},"posted":{"date-parts":[[2026,9,16]]},"group-title":"Neuroscience","reference-count":66,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["U01NS123127"],"award-info":[{"award-number":["U01NS123127"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"name":"James G. Boswell Foundation"},{"id":[{"id":"https:\/\/ror.org\/00k0a6x92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"T&C Chen Brain-Machine Interface Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>The cortical grasping network (CGN) is responsible for the ability to physically interact with the world around us using our hands. For patients with motor impairments due to neurogenerative disease or traumatic injury, brain-machine interfaces (BMIs) offer a potential pathway towards restoration of dexterous hand control via recording neural activity throughout the CGN. However, grasping objects with robotic BMI devices has proved challenging, when utilizing neural signals from only motor cortex (MC, a subregion of the CGN). It is currently unclear how the presence of an object might compromise BMI performance; thus this work explores the interactive neural representation of grasp and objects throughout the CGN.<\/jats:p>\n                <jats:p>Three tetraplegic human participants performed grasp motor imagery during imagined object manipulation while we recorded neural activity from the supramarginal gyrus (SMG), anterior intraparietal cortex (AIP), motor cortex (MC), and primary somatosensory cortex (S1). All regions within the CGN represented whole hand configuration of imagined grasps during motor planning and imaged execution. Additionally, grasp-related neural activity in each region was modulated by context (motor planning vs. imagined execution and object present vs. not present). SMG and AIP represented object shape during motor planning. PPC encoded both grasp and object properties simultaneously from mostly unique subpopulations of neurons. This separability in higher cortical regions could be a critical for stable BMI grasp performance.<\/jats:p>","DOI":"10.64898\/2026.09.10.750758","type":"posted-content","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:56:17Z","timestamp":1789592177000},"source":"Crossref","is-referenced-by-count":0,"title":["Neural encoding of grasp and object properties in the posterior parietal and motor cortices of the cortical grasping network in tetraplegic humans"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-3305","authenticated-orcid":false,"given":"Mackenzie J.","family":"Thurston","sequence":"first","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, 91101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-5916","authenticated-orcid":false,"given":"David","family":"Bj\u00e5nes","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"Department of Electrical and Computer Engineering, Neurosurgery, University of Utah, Salt Lake City, UT 84112, USA"},{"name":"T&C Chen Brain-machine Interface Center, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-8491","authenticated-orcid":false,"given":"Sarah","family":"Wandelt","sequence":"additional","affiliation":[{"name":"Blackrock Neurotech Inc., Salt Lake City, UT 84108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsie","family":"Pejsa","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"T&C Chen Brain-machine Interface Center, California Institute of Technology, Pasadena, CA 91125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, CA 90033, USA"},{"name":"USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-8577","authenticated-orcid":false,"given":"Charles","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA"},{"name":"Blackrock Neurotech Inc., Salt Lake City, UT 84108, USA"},{"name":"Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, CA 90033, USA"},{"name":"USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7947-0472","authenticated-orcid":false,"given":"Richard A.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA"},{"name":"T&C Chen Brain-machine Interface Center, California Institute of Technology, Pasadena, CA 91125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026091822000898000_2026.09.10.750758v1.1","unstructured":"Edemekong, P. 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