{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:05:40Z","timestamp":1789664740445,"version":"4.0.1"},"posted":{"date-parts":[[2026,9,13]]},"group-title":"Geriatric Medicine","reference-count":78,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"funder":[{"award":["1R01AG062691-01"],"award-info":[{"award-number":["1R01AG062691-01"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Non-pharmacological interventions may enhance motor-cognitive integration in prodromal Alzheimer\u2019s disease (pAD). Partnered Rhythmic Rehabilitation (PRR), an adapted dance-based intervention, is designed to engage the motor, cognitive, and social domains. However, no randomized trial has evaluated its feasibility or efficacy in pAD. This study evaluated the feasibility, safety, and preliminary efficacy of PRR compared to group walking (WALK) in adults with pAD and amnestic mild cognitive impairment (aMCI).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>\n                    In this single-blind, randomized controlled pilot trial (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04029623\">NCT04029623<\/jats:ext-link>\n                    ), 68 adults with pAD and aMCI were randomized to PRR or WALK. Prespecified feasibility criteria were attrition \u226415% and no injurious falls during interventions. Preliminary efficacy was examined on the primary outcome, the Four-Square Step Test (FSST). Secondary cognitive, motor, and psychosocial outcomes were also assessed to inform future definitive trials. Several modifications were made to the original protocol to ensure compliance with safety measures associated with the COVID-19 pandemic.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Attrition in the PRR group (15.2%) did not significantly exceed the prespecified threshold (P = .848), and 0 injurious falls were reported during the supervised sessions, meeting both feasibility and safety criteria. No significant group-by-time interactions were observed for FSST, but significant group-by-time interactions favoring PRR were identified for Timed Up-and-Go (TUG; P = .021) and jump distance (P = .014).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PRR was feasible and safe in adults with aMCI consistent with pAD but did not meet the prespecified efficacy endpoint on FSST. Our results showed that TUG and standing board jump distance may serve as potential outcomes in future definitive trials.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.09.11.26362767","type":"posted-content","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T21:10:14Z","timestamp":1789333814000},"source":"Crossref","is-referenced-by-count":0,"title":["Feasibility, Safety, and Preliminary Efficacy of Partnered Rhythmic Rehabilitation in Prodromal Alzheimer\u2019s Disease: A 12-Month Pilot Randomized Controlled Trial"],"prefix":"10.64898","author":[{"given":"Forouzan","family":"Rafie","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Geriatrics and Gerontology, Emory University School of Medicine, Atlanta, GA, United States, 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Azimi","sequence":"additional","affiliation":[{"name":"Emory University College of Arts and Sciences, Atlanta, GA, United States, 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir H.","family":"Nekouei","sequence":"additional","affiliation":[{"name":"Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran"},{"name":"Oral and Dental Disease Research Center, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics and Gerontology, Emory University School of Medicine, Atlanta, GA, United States, 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathleen M.","family":"Carroll-Sauer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics and Gerontology, Emory University School of Medicine, Atlanta, GA, United States, 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Southwestern, Dallas, TX, United States, 75390"},{"name":"Department of Neurology, Baylor College of Medicine, TX, United States, 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Wharton","sequence":"additional","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, United States, 30322"},{"name":"Goizueta Alzheimer\u2019s Disease Research Center, Emory University, Atlanta, GA, United States, 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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