{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:09:48Z","timestamp":1789826988223,"version":"4.0.1"},"posted":{"date-parts":[[2026,9,16]]},"group-title":"Radiology and Imaging","reference-count":49,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"name":"National Institutes of Health","award":["1ZIAEY000558"],"award-info":[{"award-number":["1ZIAEY000558"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Interactions between light and biological tissue could reveal disease-related changes that could be advantageous for rapid diagnosis when applied to whole limbs. Here, we tested the extent to which visible\/near-infra-red hyperspectral imaging (HSI) deployed in the emergency department could classify cellulitis, non-cellulitis edema, and healthy lower-leg tissue across skin pigmentation types. We collected HSI data of the lower leg from 83 emergency-room patients and analyzed the calibrated normalized spectra (400-1000 nm) using a machine-learning classification algorithm, evaluated by cross-validation and benchmarked against standard spectral indices (oxygenation, hemoglobin, water, near-infrared perfusion). Classification at patient-level and pixel-level resolution performed comparably well using whole-spectrum and indices, for cellulitis versus healthy (AUC: 0.93 vs. 0.96) and non-cellulitis edema versus cellulitis (AUC: 0.92 vs. 0.89). Full-spectrum analysis substantially improved non-cellulitis edema versus healthy classification (patient-level AUC: 0.72 vs. 0.41; pixel-level AUC: 0.78 vs. 0.50), with no significant effect of skin type on accuracy.<\/jats:p>","DOI":"10.64898\/2026.09.15.26363173","type":"posted-content","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:45:19Z","timestamp":1789609519000},"source":"Crossref","is-referenced-by-count":0,"title":["Hyperspectral imaging in the emergency department to characterize lower leg edema"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3592-0960","authenticated-orcid":false,"given":"Karthik","family":"Kasi","sequence":"first","affiliation":[{"name":"Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"May","sequence":"additional","affiliation":[{"name":"Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Gallegos","sequence":"additional","affiliation":[{"name":"Dept. of Emergency Medicine, Brown University Health, Providence RI 02903"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Dept. of Emergency Medicine, Brown University Health, Providence RI 02903"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-9253","authenticated-orcid":false,"given":"Bevil R.","family":"Conway","sequence":"additional","affiliation":[{"name":"Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda MD 20892"},{"name":"National Institute of Mental Health, NIH, Bethesda MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Pare","sequence":"additional","affiliation":[{"name":"Dept. of Emergency Medicine, Brown University Health, Providence RI 02903"},{"name":"Brown University, Providence RI 02903"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026091906450653000_2026.09.15.26363173v1.1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.31.3.030901"},{"key":"2026091906450653000_2026.09.15.26363173v1.2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.1.010901"},{"key":"2026091906450653000_2026.09.15.26363173v1.3","doi-asserted-by":"publisher","DOI":"10.1007\/s13206-021-00041-0"},{"key":"2026091906450653000_2026.09.15.26363173v1.4","doi-asserted-by":"publisher","DOI":"10.3390\/s22249790"},{"key":"2026091906450653000_2026.09.15.26363173v1.5","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.28.4.040901"},{"key":"2026091906450653000_2026.09.15.26363173v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/86684"},{"key":"2026091906450653000_2026.09.15.26363173v1.7","doi-asserted-by":"publisher","DOI":"10.3791\/67403"},{"key":"2026091906450653000_2026.09.15.26363173v1.8","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12474"},{"key":"2026091906450653000_2026.09.15.26363173v1.9","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13474"},{"key":"2026091906450653000_2026.09.15.26363173v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16232-0"},{"key":"2026091906450653000_2026.09.15.26363173v1.11","doi-asserted-by":"publisher","DOI":"10.1109\/REM.2019.8744086"},{"key":"2026091906450653000_2026.09.15.26363173v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2026.03.025"},{"key":"2026091906450653000_2026.09.15.26363173v1.13","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23479"},{"key":"2026091906450653000_2026.09.15.26363173v1.14","doi-asserted-by":"publisher","DOI":"10.3233\/CH-179228"},{"key":"2026091906450653000_2026.09.15.26363173v1.15","unstructured":"Probst A . 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